In vivo #CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. From Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues: rupress.org/jem/article/...

📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti...

#AAI2026

IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/...

📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti...

#AAI2026

Parse or 10x? any advice? we're thinking about trying Parse but would love some feedback from the #immunology community. this sequencing project is for lung #macrophages if that matters? please circulate and send me any info about your experiences!! @jeffmold.bsky.social have you used Parse?

So TB is back in a big way in the US — 10,388 cases last year, highest since 2011. Four straight years of increases after decades of decline. The mix is rough: reactivated latent infections, outbreaks in shelters and prisons, and federal funding getting slashed right when we need it most. 2025 numbers look even worse. We were supposed to be eliminating this disease, not watching it rebound. https://crowdbyte.ai/topics/deadly-infectious-disease-rebounds-in-us-after-eradication-hopes

#Tuberculosis ! "So TB is back in a big way in the US—10,388 cases last year.... The mix is rough: reactivated latent infections, outbreaks in shelters and prisons, and federal funding getting slashed right when we need it most."
crowdbyte.ai/topics/deadl...
www.threads.com/@crowd_byte/...

New #IJID editorial: Scientific advances in TB are accelerating, but global impact is not keeping pace. The challenge is no longer innovation—it is implementation.

🔗 Read more: https://ow.ly/3IJS50YzsyM

#WorldTBDay #EndTBwithISID #Tuberculosis #ISID

📣Still time to apply! Don’t miss your chance to secure an EFIS–EJI Travel Award! #EarlyCareerResearcher #Immunology

Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al...

Link to publications:
www.cell.com/immunity/ful...

doi.org/10.1016/j.im...

Large mapping of hereditary differences in the immune system Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...

Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

#HIV overactivates the #immunesystem, causing long-term dysfunction. New research from Linköping University @liu.se shows the #lupus drug #anifrolumab may restore immune cell function, opening the door to immune repair strategies alongside antivirals. #Immunology www.linkedin.com/posts/drmelv...

Structural and genetic basis of #HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies. From Roark, Habib, Shaw, Kwong, Shapiro et al.: rupress.org/jem/article/...

📘 Updates on the Immune Responses to #Tuberculosis & #HIV rupress.org/jem/collecti...
#KSTB26 #KSHIVVax26

Yes! We Can End TB. Led by Africa. Powered by People.

This #WorldTBDay, we call on African governments to:

🔹 Strengthen people-centred TB services
🔹 Close the funding gap with domestic resources
🔹 Advance regional manufacturing

🔗 Read the letter from GFAN Africa: bit.ly/WTBD-GFANafr...

#EndTB

Deconvoluting the interplay of innate & adaptive immunity in BCG-induced nonspecific & #TB-specific host resistance. Perspective by @kerryhilligan.bsky.social et al rupress.org/jem/article/...

📘 Updates on the Immune Responses to #Tuberculosis & #HIV rupress.org/jem/collecti...
#KSTB26 #KSHIVVax26

#immunology #immunosky #Bcell #immunogenetics

The authors also created an online resource: the Karolinska Institutet Adaptive Immune Receptor Gene Variant Atlas (KIARVA) where you can download the updated dataset. Found here: kiarva.scilifelab.se

This is a massive effort by Martin Corcoran and Gunilla Karlsson Hedestam at @ki.se

If you work with B cells and clone antibodies or look at BCR sequences, this new study out in @cp-immunity.bsky.social is a must read: www.sciencedirect.com/science/arti...

More than 500 allelic variants identified in 25 different Global populations.

This matters for biology and SHM calculations!

Tuberculosis at a crossroads This World Tuberculosis Day, as ever, the world has everything it needs to end tuberculosis in our lifetimes. Yet in 2024, 1·23 million people died of tuberculosis, indicating that tuberculosis persis...

"This World TB Day, as ever, the world has everything it needs to end tuberculosis in our lifetimes. Yet in 2024, 1·23 million people died of tuberculosis, indicating that tuberculosis persists as the world's deadliest infectious disease" @lancetgh.bsky.social

www.thelancet.com/journals/lan...

@yssi-immunology.bsky.social

I'll be speaking at the @yefis-immunology.bsky.social webinar next week. Tune in for some mRNA #tuberculosis vaccine updates.

Widespread Fab-arm exchange affects all endogenous serum IgG4 - Nature Communications Among the antibody subclasses, IgG4 is unique in its capability to fragment-antigen-binding (Fab)-arm exchange, a process that renders IgG4 bispecific for antigen binding. Here authors analyse serum I...

This is wild and crazy-- IgG4 frequently switched Fab arms
#Immunosky
🧪
www.nature.com/articles/s41...

B cell imprinting in children impairs antibodies to the haemagglutinin stalk - Nature Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

'After consecutive primary heterosubtypic infections, 4–6% of memory B cells in children are cross-group reactive. These imprinted B cells target the central stalk epitope of HA and exhibit major functional differences.'
#Immunology
www.nature.com/articles/s41...

The uterus' immune system can regenerate after transplantation The immune system in the uterus can regenerate after both uterus transplantation and bone marrow transplantation. This is shown by a new study from Karolinska Institutet that has been published in the...

The immune system in the #uterus can regenerate after uterus or bone marrow transplantation, finds a KI study published in Science Translational Medicine. The new insights may be significant for the treatment of infertility and pregnancy complications 🧪 #Immunology news.ki.se/the-uterus-i...

🔬 Help shape the future of immunology! The Journal of Immunology is seeking expert Section Editors to lead our peer-review process and maintain the highest standards of scientific excellence. Join the team today!

📅 Apply by March 31, 2026
🔗 https://ow.ly/oB1G50YoERS

#Immunology

Out now in #Science #Immunology! 👇

A new cell-free genomics framework from Rockefeller's Elizabeth Campbell in @cp-molcell.bsky.social isolates the primary impacts of transcription factors and establishes #tuberculosis as a model for understanding how genes are regulated.

🔗: https://bit.ly/4s8QScX

Unsurprising yet still depressing
#TBSky #IDSky

There are just a few days left to apply. #Tuberculosis 🧪🦠 #TBDrugDiscovery

Call for Abstracts - Cytokines 2026 Click here to submit your abstract IMPORTANT DATES Event Date Abstract Submission deadline (Student/PostDoc Travel Award application) Friday,15 May, 2026, 23:59 GMT Notification to submitters…

🔬 Abstract submissions are OPEN for #Cytokines2026 in Glasgow! Deadline: May 15, 2026. Student/postdoc members can apply for travel awards at submission. Submit now: 2026.cytokinesociety.org/call-for-abs... #CytokineSociety #Immunology

Tomorrow, in #preprinthub2 @alisaiakupova.bsky.social will present a preprint from Xuyu Zhou’s lab on how #TCR signal strength determines #Treg instability and discrimination of self versus non-self antigens 🐁 ⏳🌪️ #immunosky

www.biorxiv.org/content/10.6...

TB and HIV treatments are not enough for a full recovery - Texas Biomed Existing treatments for tuberculosis (TB) and HIV control the pathogens, but the immune system does not revert to normal, according to research by Texas

Existing treatments for #tuberculosis and HIV control the pathogens, but the immune system does not revert to normal

The preclinical findings help explain why people living with #HIV likely remain more susceptible to other illness and reinfection with #TB – and point to the need for new therapies

Tackling tuberculosis systematically: How the environment shapes TB risk In a new study, LMU researchers present an approach that views tuberculosis as the result of broader systemic forces.

LMU researchers led by Mikaela Coleman & Katharina Kranzer present an approach that views #tuberculosis as the result of broader systemic forces. The “tuberculogenic environment” sees TB not only as a medical problem, but as a consequence of broader systemic forces shaping health and vulnerability.🩺