Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

🥳 Our 2nd most downloaded article in 2025:

Targeted protein degradation for cancer therapy

#PROTACs #Degraders @NatResCancer
#NRCtop10of2025

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss the mechanisms of acquired resistance and the models to better study it. Finally, they promote integration of biomarker-driven strategies and cutting-edge technologies to advance predictive and proactive prevention in cancer therapy.

🥳 Our 3rd most downloaded #REVIEW in 2025:

Acquired resistance in cancer: towards targeted therapeutic strategies

#therapyresistance #cancertherapy @NatResCancer
#NRCtop10of2025

Neuro-immune cross-talk in cancer - Nature Reviews Cancer The nervous and immune systems have co-evolved to respond to threats, including cancer. In this Review, Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.

🥳 Our 4th most downloaded #REVIEW in 2025:

Neuro-immune cross-talk in cancer

#neuroimmune #cancer @NatResCancer
#NRCtop10of2025

Cross-priming in cancer immunology and immunotherapy - Nature Reviews Cancer In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

🥳 Our 5th most downloaded #REVIEW in 2025:

Cross-priming in cancer immunology and immunotherapy
#TME #immunotherapy

@NatResCancer
#NRCtop10of2025

Dendritic cell maturation in cancer - Nature Reviews Cancer Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms through which cancer impairs DC maturation and considers the potential for DC-focused cancer immunotherapeutics.

🥳 Our 6th most downloaded #REVIEW in 2025:

Dendritic cell maturation in cancer

#dendriticcells #TME @NatResCancer
#NRCtop10of2025

Recent advances in therapeutic cancer vaccines - Nature Reviews Cancer Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development and clinical translation continues to face challenges. Here, Zaidi, Jaffee and Yarchoan summarize the failures of cancer vaccines of the past, to highlight recent advancements in the field.

🥳 Our 7th most downloaded #REVIEW in 2025:

Recent advances in therapeutic cancer vaccines

#cancervaccines @NatResCancer
#NRCtop10of2025

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection - Nature Reviews Cancer In this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement existing screening programmes or enhance early cancer detection for those cancers without effective screening methods.

🥳 Our 8th most downloaded #REVIEW in 2025:

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

#cfDNA #liquidbiopsy @NatResCancer
#NRCtop10of2025

The immune microenvironment of colorectal cancer - Nature Reviews Cancer In this Review, Kennel and Greten highlight the role of immune cells in colorectal cancer (CRC) development, progression and metastasis as well as the impact of therapies on the immune microenvironment. They emphasize the need for novel strategies to enhance immunogenicity and CRC patient stratification to improve outcomes.

🥳 Our 9th most downloaded #REVIEW in 2025:

The immune microenvironment of colorectal cancer

#TME #colorectalcancer @NatResCancer
#NRCtop10of2025

Ageing, immune fitness and cancer - Nature Reviews Cancer Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

🥳 First up in #NRCtop10of2025:

#10) Ageing, immune fitness and cancer

#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
#NRCtop10of2025

Get ready...

🚨 Starting Monday, we're counting down the top 10 most downloaded #REVIEW articles of 2025! 🚨

Don't miss it! 🎉

#NRCtop10of2025

When the time is right - Nature Reviews Cancer In a study published in Nature, Lourenço et al. demonstrate that strong oncogenic driver mutations undergo negative selection unless they occur in a permissive tissue context.

ICYMI 🚨

#ResearchHighlight on a study published in @Nature demonstrating that strong oncogenic driver mutations undergo negative selection unless they occur in a permissive tissue context.
📖👇

Opportunities and challenges of targeting cGAS–STING in cancer - Nature Reviews Cancer In this Review, Lu et al. discuss the dual role of the cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) pathway in cancer, emphasizing its involvement in both tumour suppression and promotion. They highlight the diverse sources of pathway activation and suggest that this functional duality may underlie the limited clinical success of cGAS–STING targeting in cancer therapy.

Weekend reading 🚨
A comprehensive #Review on the dual role of the #cGAS–#STING pathway in cancer, emphasizing its involvement in both tumour suppression and promotion, which might underlie the limited clinical success of cGAS–STING targeting in cancer therapy.
📖👇

Artificial intelligence agents in cancer research and oncology - Nature Reviews Cancer Artificial intelligence agents are autonomous systems that use large language models to reason and as such can perform complex, multistep tasks with minimal human oversight. This Review by Truhn et al. discusses how these agents — which have already been implemented in several industries — could transform cancer research and oncology, and looks at the challenges that need to be addressed before they can be efficiently and safely used.

#REVIEW 🚨

#AI agents perform complex tasks with minimal human oversight. This Review by @jnkt.bsky.social et al. discusses how AI could transform oncology & the challenges to address for efficient & safe use.


👇 📖

Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:

- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing

Check it out 👇
http://bit.ly/4oUyzq

Ageing and Cancer Ageing is a fundamental driver of cancer, fostering the accumulation of genetic and epigenetic changes that disrupt cellular homeostasis, promote immune ...

Check out our focused collection of articles highlighting research on ageing and cancer to better cancer prevention, diagnostics and therapy.
www.nature.com/collections/...

It features #Comments #Reviews #Perspectives from leaders in the field: a 🧵

How does ageing affect cancer? Read all about it in our latest Focus isse ⬇️

The impact of sex on metastasis - Nature Reviews Cancer Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate for mechanistic and quantitative studies for the future development of sex-tailored therapies.

As part of our Series on #SexDifferences in cancer, Yingsheng Zhang & Xue Li wrote a Comment article that outlines the impact of #sex on #metastasis. Check it out ⬇️

Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity - Nature Reviews Cancer Neurotoxicity impacting the central and peripheral nervous systems is a considerable adverse effect of both conventional and novel cancer therapies. In this Review, Karschnia et al. outline what is currently known about the mechanisms that underlie the clinical symptoms of central nervous system injury and peripheral neuropathy and the ongoing development of interventions to treat and prevent this unmet medical need.

Review🚨

Karschnia, Nelson & Dietrich outline what is currently known about the mechanisms that underlie the clinical symptoms of cancer therapy-related central nervous system injury and peripheral neuropathy

📖👇

Our SEPTEMBER issue is live! 🌤️🍂🌻🍂

It features articles on:
- ER stress responses in anti-cancer immunity
- Regulatory T cells in the TME
- Metabolic adaptations of brain metastasis
- Engineering strategies for nanoparticles

Read it now👇
bit.ly/4mW1JnQ

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.

We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky

www.nature.com/articles/d41...

Gender and sex interactions are intrinsic components of cancer phenotypes - Nature Reviews Cancer In this Perspective, Joshua Rubin emphasizes the importance of gender–sex interaction (GSI) differences in cancer biology and clinical parameters to enhance precision medicine. He outlines the challenges and opportunities of integrating GSI effects into personalized oncology and argues that optimal outcomes require extending our current molecular approaches to include family history, life history and individual vulnerabilities in our diverse groups of patients with cancer.

🚨 PERSEPCTIVE 🚨

Here Joshua Rubin emphasizes the challenges, opportunities and importance of integrating gender-sex interaction differences into cancer biology & clinical parameters to enhance precision medicine. @uwsom-wwami.bsky.social‬

👇 📖 for more details

Congratulations!!!

Jordan Lee describes the Tumor Molecular Pathology (TMP) machine learning toolkit that can classify new samples into previously defined #TCGA molecular subtypes
@ohsunews.bsky.social
👀 ⬇️

Metabolic interplays between the tumour and the host shape the tumour macroenvironment - Nature Reviews Cancer In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...

At the #KSTumorMetab25 meeting?

Check out the latest review by Ayelet Erez & colleagues for more details on how metabolic interplay between the tumour & the host shape the tumour macroenvironment.

👀⬇️
bit.ly/3ReWTEo

#REVIEW🚨

Velculescu & Team review targeted and genome-wide #cfDNA detection approaches and discuss their potential to complement existing screening programs or enhance early cancer detection for those cancers without effective screening methods.

Review

#ResearchHighlight 🚨
‪@claballabio.bsky.social‬ from Leanne Li group @crick.ac.uk show that #neuroendocrine #SCLC cells exhibit electrical activity that drives tumour progression. They rely on OXPHOS to meet the high energy demand of these electrophysiological processes. 👀⬇️