New Perspective on Voxel-Based Analysis (VBA) in Radiotherapy. www.mdpi.com/2077-0383/14...

How do parameter choices impact dose-toxicity predictions in #radiotherapy? A #pcuk funded investigation tried to question the question and the findings may surprise you. Read the full study: www.sciencedirect.com/science/arti...

Can we better predict bowel and bladder side effects in men with #ProstateCancer receiving #Radiotherapy?

@PuriTanuj.bsky.social and team @manchester.ac.uk investigate and compare dose-response mapping approaches, writing in phiRO.

Grab a ☕ and read: doi.org/10.1016/j.ph...

Puri, Tanuj and Choudhury, Ananya and Dunning, Alison M. and Farcy Jacquet, Marie-Pierre and de Ruysscher, D. and Azria, David and Avuzzi, Barbara and Gioscio, Eliana and West, Catharine ML and McWilliam, Alan and Kerns, Sarah and Shortall, Jane and Lambrecht, Maarten and Sperk, Elena and Seibold, Petra and van Herk, Marcel and Chang-Claude, Jenny and Webb, Adam and Veldeman, Liv and Vega, Ana and Rosenstein, Barry S. and J Talbot, Christopher and Vasquez Osorio, Eliana and rancati, tiziana and Morris, Andrew P. and Green, Andrew and Hoskin, Peter J., Comparison of Dose-Response Maps of the Bladder and Rectum in Prostate Cancer Patients Undergoing Radiotherapy With and Without Baseline Toxicity Normalization (November 18, 2024). Available at SSRN: https://ssrn.com/abstract=5028585 or http://dx.doi.org/10.2139/ssrn.5028585

Comparing Radiation Effects on the Bladder and Rectum in Prostate Cancer Patients: With and Without Adjusting for Pre-Treatment Side Effects #prostatecancer #radiotherapy #toxicities #biomarkers #predictionmodels #VBA #IBDM #OAR #bladder #rectum ssrn.com/abstract=502...

Puri, Tanuj and Choudhury, Ananya and Dunning, Alison M. and Farcy Jacquet, Marie-Pierre and de Ruysscher, D. and Azria, David and Avuzzi, Barbara and West, Catharine ML and McWilliam, Alan and Kerns, Sarah and Lambrecht, Maarten and Sperk, Elena and Seibold, Petra and van Herk, Marcel and Chang-Claude, Jenny and Webb, Adam and Veldeman, Liv and Vega, Ana and Rosenstein, Barry S. and J Talbot, Christopher and Vasquez Osorio, Eliana and rancati, tiziana and Hoskin, Peter J., Sensitivity of Bladder Dose-Response to Model Parameters in Prostate Cancer Radiotherapy (January 18, 2025). Available at SSRN: https://ssrn.com/abstract=5105722

Sensitivity of Bladder Dose-Response to Model Parameters in Prostate Cancer Radiotherapy #CancerResearch #Radiotherapy #ProstateCancer ssrn.com/abstract=510...

Puri T, Blake GM, Frost ML, Siddique M, Moore AE, Marsden PK, Cook GJ, Fogelman I, Curran KM. Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using 18F-fluoride PET-CT. Nucl Med Commun. 2012 Jun;33(6):597-606. doi: 10.1097/MNM.0b013e3283512adb. PMID: 22441132. Puri, T. (2011). Bone metabolism measured with six quantification methods using 18F-PET, World Molecular Imaging Congress. In World Molecular Imaging Congress, 7-10 Sept 2011, San Diego, California, USA. https://lnkd.in/e7XvCEaR

What are the 6 ways to quantify [18F]NaF PET-CT imaging? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #HealthyBones #BoneResearch #ImagingInnovation #EarlyDetection #StrongBones

Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018 Feb;8(1):47-59. doi: 10.21037/qims.2018.01.02. PMID: 29541623; PMCID: PMC5835654.

What are precision errors, and what do they mean in [18F]NaF PET imaging? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #boneimaging
doi: 10.21037/qims.2018.01.02

Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018 Feb;8(1):47-59. doi: 10.21037/qims.2018.01.02. PMID: 29541623; PMCID: PMC5835654.

When using [18F]NaF PET, which is the most effective parameter to assess treatment response? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #ImagingInnovation doi: 10.21037/qims.2018.01.02

Zhang Y, Chen Y, Huang Z, Zhang L, Wan Q, Lei L. Comparison of 18F-NaF PET/CT and 18F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma. Contrast Media Mol Imaging. 2018 Sep 5;2018:8271313. doi: 10.1155/2018/8271313. PMID: 30254551; PMCID: PMC6145050.

[18F]NaF vs [18F]FDG PET-CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer doi: 10.1155/2018/8271313

Lin, F.I., Rao, J.E., Mittra, E.S. et al. Prospective comparison of combined 18F-FDG and 18F-NaF PET/CT vs. 18F-FDG PET/CT imaging for detection of malignancy. Eur J Nucl Med Mol Imaging 39, 262–270 (2012).

[18F]FDG+[18F]NaF PET-CT vs [18F]FDG PET-CT imaging for detection of malignancy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #CancerResearch #BoneRemodeling doi: 10.1007/s00259-011-1971-1

Cocktail [18F]FDG &[18F]NaF vs [18F]FDG PET Breast Cancer metastases #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #ImagingInnovation #cancer #breastcancer #women #breast doi: 10.1097/RLU.0000000000001615

Iagaru A, Mittra E, Yaghoubi SS, Dick DW, Quon A, Goris ML, Gambhir SS. Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study. J Nucl Med. 2009 Apr;50(4):501-5. doi: 10.2967/jnumed.108.058339. Epub 2009 Mar 16. PMID: 19289439.

Cocktail [18F]NaF and [18F]FDG PET-CT Scan for Evaluation of Malignancy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.2967/jnumed.108.058339

[18F]NaF PET Ki is considered a marker of bone formation, then, why is it used to study cancer-related bone metastases? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging www.linkedin.com/feed/update/...

Boivin G, Farlay D, Khebbab MT, Jaurand X, Delmas PD, Meunier PJ. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Osteoporos Int. 2010 Apr;21(4):667-77. doi: 10.1007/s00198-009-1005-z. Epub 2009 Jul 14. PMID: 19597910.

Strontium Ranelate Keeps Bones Strong: How It Supports Healthy Bone Formation in Osteoporotic Women! #BoneHealth #HealthyBones #Osteoarthritis #BoneResearch #ImagingInnovation #StrongBones #BoneWellness #BoneStrength #BoneRemodeling #EarlyDetection doi: 10.1007/s00198-009-1005-z

Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab (1994) 79(6):1693–700. doi: 10.1210/jcem.79.6.7989477

When to perform [18F]NaF PET scan for estimating bone metabolism post-treatment? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1210/jcem.79.6.7989477

Happy New Year to All #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #HealthyBones #Osteoarthritis #BoneResearch #ImagingInnovation #cancer #prostatecancer #breastcancer #metastasis

Detecting Bone Spread in Bladder Cancer - [18F]NaF PET-CT vs 99mTc-MDP SPECT-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #bonecancer
doi: 10.1097/RLU.0b013e31828da5cc

Cook, G.J., Parker, C., Chua, S. et al. 18F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin). EJNMMI Res 1, 4 (2011). https://lnkd.in/es9x4ckh

[18F]NaF PET as a Way to Track Treatment Response in Bone Metastases from Prostate Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging
#cancer #prostat #prostatecancer DOI: 10.1186/2191-219X-1-4

Jadvar H, Desai B, Conti PS. Sodium 18F-fluoride PET/CT of bone, joint, and other disorders. Semin Nucl Med. 2015 Jan;45(1):58-65. doi: 10.1053/j.semnuclmed.2014.07.008.

[18F]NaF vs [18F]FDG PET-CT in Detecting Occult Metastatic Disease in Prostate Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #prostatecancer doi: 10.1053/j.semnuclmed.2014.07.008

Hu H, Hu X, Liang Z, Yang W, Li S, Li D, Cai J. Diagnostic performance of 18F‑FDG PET/CT vs. 18F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncol Lett. 2024 Sep 12;28(5):546. doi: 10.3892/ol.2024.14679. PMID: 39319212; PMCID: PMC11420642.

[18F]FDG vs [18F]NaF PET-CT in breast cancer with bone metastases #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #ImagingInnovation
doi: 10.3892/ol.2024.14679

Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med. 2006 Feb;47(2):287-97. PMID: 16455635.

[18F]NaF PET for Detecting Bone Metastases in Prostate Cancer Patients #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneImaging #BoneRemodeling #EarlyDetection #prostatecancer #cancer jnm.snmjournals.org/content/47/2...

Aaltonen L, Koivuviita N, Seppänen M, Tong X, Kröger H, Löyttyniemi E, Metsärinne K. Correlation between 18F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients. Bone. 2020 May;134:115267. doi: 10.1016/j.bone.2020.115267. Epub 2020 Feb 11. PMID: 32058018.

Correlation between [18F]NaF PET and bone histomorphometry in renal osteodystrophy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1016/j.bone.2020.115267

Puri T, Frost ML, Moore AEB, Cook GJR, Blake GM. Input function and modeling for determining bone metabolic flux using [18 F] sodium fluoride PET imaging: A step-by-step guide. Med Phys. 2023 Apr;50(4):2071-2088. doi: 10.1002/mp.16125. Epub 2022 Dec 17. PMID: 36433629.

[18F] NaF PET Ki vs SUV? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection #ArthritisAwareness doi: 10.1002/mp.16125

Araz M, Aras G, Küçük ÖN. The role of 18F-NaF PET/CT in metastatic bone disease. J Bone Oncol. 2015 Sep 16;4(3):92-7. doi: 10.1016/j.jbo.2015.08.002. PMID: 26587375; PMCID: PMC4648995.

Role of [18F]NaF PET-CT in Diagnosing Bone Metastases #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #metastases #bone doi: 10.1016/j.jbo.2015.08.002

Petrén-Mallmin, M., Andréasson, I., Ljunggren, Ö. et al. Skeletal metastases from breast cancer: uptake of 18F-fluoride measured with positron emission tomography in correlation with CT. Skeletal Radiol 27, 72–76 (1998). https://doi.org/10.1007/s002560050340

[18F]NaF PET for Detecting Bone Metastases in Breast Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #breastcancer doi.org/10.1007/s002...

Schirrmeister H, Glatting G, Hetzel J, Nüssle K, Arslandemir C, Buck AK, Dziuk K, Gabelmann A, Reske SN, Hetzel M. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med. 2001 Dec;42(12):1800-4. PMID: 11752076. https://jnm.snmjournals.org/content/42/12/1800.long

[18F]NaF PET is more accurate for detecting bone spread than planar bone scans or SPECT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging
jnm.snmjournals.org/content/42/1...

Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, et al. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Br J Radiol 2014;87:20130444.

[18F]NaF PET in differentiated thyroid carcinoma
#18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling doi: 10.1259/bjr.20130444

Special Issue Information (Submission Deadline: 20 May 2025) #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling #EarlyDetection www.mdpi.com/journal/jcm/...

Chan SC, Wang HM, Ng SH, Hsu CL, Lin YJ, Lin CY, Liao CT, Yen TC. Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. J Nucl Med. 2012 Nov;53(11):1730-5. doi: 10.2967/jnumed.112.104893. Epub 2012 Sep 7. PMID: 22961077.

[18F]NaF PET for Detecting Bone Spread in Head & Neck Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #ImagingInnovation doi: 10.2967/jnumed.112.104893

Usmani S, Marafi F, Esmail A, Ahmed N. Initial experience with 18F-sodium fluoride (NaF) PET-CT: a viable functional biomarker in symptomatic Os acromiale. Br J Radiol. 2018 Apr;91(1084):20170741. doi: 10.1259/bjr.20170741. Epub 2018 Jan 12. PMID: 29293370; PMCID: PMC5966011.

Shoulder Pain Mystery Solved with [18F]NaF PET #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1259/bjr.20170741