Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...

Very excited that this meeting will be in Belfast next year!

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

NLRP3 is a thermosensor that is negatively regulated by high temperature Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...

Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.

www.biorxiv.org/content/10.1...

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

Thank you Franklin!! 🔥😃

Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors Discover the world’s best science and medicine | Nature.com

Nice to see our recent study on novel NLRP3 inhibitors with
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...

@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...

#Inflammasome #Inflammation

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!

Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...

Congratulations to our latest cohort of summer students @WWIEM @qubelfastofficial.bsky.social for a fantastic final poster session - the standard was exceptionally high. Special shout out to Timothy Okafor who was a pleasure to host in my lab!!

Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!

www.embopress.org/doi/full/10....

Paper accepted!!!

Huge congratulations to the new Dr Thea Mawhinney!! Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo.bsky.social and Prof Cliff Taggart @wwiem-qub.bsky.social

Cockatoos have learned to operate drinking fountains in Australia.

The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G

I'm delighted to be hosting a #NLRP3 InflammaZoom spectacular next week! With Alex Weber and Ana Tapia Abellan - please join us on Monday 19th May. Register here: events.abcam.com/event/Inflam...

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

Agreed it's not quite beach weather yet!

Oh 100% it's barely 16 - we need our vitamin D!

You've got to love the Irish enthusiasm for a bit of good weather 16°C=summertime 😎

Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast on FindAPhD.com PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

Brilliant and elegant work from @jelenalab.bsky.social - showing yet again the complexity of how our immune system keeps itself in check!!

Queen's University Belfast has launched it's call for MSCA postdoctoral fellowship applications - if anyone would like to discuss submitting a project please get in touch! #MCSA @wwiem-qub.bsky.social www.qub.ac.uk/Research/our...

New insights into the noncanonical inflammasome point to caspase-4 as a druggable target - Nature Reviews Immunology This Progress article describes recent studies showing that the human lipopolysaccharide sensor caspase-4 activates pro-IL-18 and causes vascular leakage by inducing pyroptosis in endothelial cells. S...

'New insights into the noncanonical inflammasome point to caspase-4 as a druggable target'
Progress article by Elad Elkayam, Francois Gervais, Hao Wu, Michael Crackower & Judy Lieberman @harvardmed.bsky.social @bostonchildrens.bsky.social
#inflammasome #immunology #immunosky

Last few days to apply for our summer online student programme - iENGAGE 2025

Join us for 6 weeks this summer, working with our researchers and gaining valuable experience on research across our areas of expertise

Apply now here:
www.qub.ac.uk/research-cen...