Top left: Schematic derived from WormPaths showing methionine salvage and arginine-derived metabolic pathways. Information regarding gene level and H3K4me3 status from Control, sams-1 or sams-4 animals in basal or heat-shocked conditions is marked in legend. Data is from Godbole and colleagues eLife 2023. Bottom left: Schematic showing connections between SAM and PC synthesis to trafficking of PC to and within the mitochondria. Right: Transmission electron micrograph of normal mitochondria (blue, top) compared to those with low levels of the phospholipid phosphatidylcholine (pink, bottom) from C. elegans intestinal cells, showing collapse of the mitochondrial network and accumulation along the intestinal lumen. Image taken by Dr. Maria Ericsson

S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt

From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS Experimental organisms such as the nematode Caenorhabditis elegans are fundamental to biological discovery. The success of C. elegans research has ...

C. elegans researchers were early adopters of open science: "The development of common resources and the belief that research findings and mutant strains should be freely shared has propelled worm research to the forefront"
www.pnas.org/doi/10.1073/...

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis: Cell www.cell.com/cell/fulltex...

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement Bayer et al. show that the DEGT-1 DEG/ENaC channel is specifically expressed in C. elegans pharyngeal neurons and localizes to the pharyngeal basement membrane. They found that DEGT-1 is required in I...

The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement

www.cell.com/current-biol...

Reaffirming the value of model organisms in training scientific minds @ishmailsaboor.bsky.social exactly what we were talking about re your #Celegans background setting you up for creative work in other systems! www.nature.com/articles/s41...

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state www.biorxiv.org/content/10.1101/2025.10....

Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.

Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.

www.science.org/doi/10.1126/...

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Just saw it on Pubmed and glanced through it. Beautiful work! Congratulations! Looking forward to reading it in detail.

Worm Show 2025 YouTube video by Morris Maduro

2025 Worm Show

youtu.be/HXgUZzLJ-b0?...

Congrats to all Poster Award Winners! Please come to the stage during the coffee break! #worm25

This microscopic image illustrates how the nematode-trapping fungus Arthrobotrys oligospora captures its prey, the nematode C. elegans. The fungus expresses cytosolic green fluorescence, while the nematode expresses pan-neuronal red fluorescence.

How do nematodes evade fungal predators? This study reveals that a #NuclearHormoneReceptor alters the #nematode cuticle, allowing them to evade #fungal adhesive traps. But this is costly, as escaping worms are more delicate & sensitive to osmotic stress @plosbiology.org 🧪 plos.io/45QMA1T

A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state - Nature Aging Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mecha...

1/7 🚨Out now @nataging.nature.com 🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C. elegans in response to nutrient cues, with conservation across taxa. www.nature.com/articles/s43...

Top left: Crystal structure of the liprin-α2_CC2N/RIM1_C2B complex. Two neighboring CC2N coiled coils (colored green and gray, respectively), with four bound C2B molecules (colored magenta), are shown. Right inset: Molecular details of interface I formed between the N-terminal part of CC2N and C2B. Salt bridges and hydrogen bonds are indicated by dashed lines. Bottom inset: Molecular details of interface II formed between the C-terminal part of CC2N and C2B. The interconnectivity between interfaces I and II in the complex of one C2B molecule and two CC2N coiled coils is displayed. Salt bridges and hydrogen bonds are indicated by dashed lines. Top right: Surface representation of C2B and CC2N, showing the spatial relationship between the PIP2-binding site and bound CC2N. Key negatively charged residues on the CC2N structure are highlighted in red. Bottom right: Confocal imaging analysis of the LLPS mixture containing the ELKS1/liprin-α2_CC12 (WT or R346E) condensate and the RIM1/RBP2_(SH3)3 condensate. Magnified views of representative RIM1 (a) and ELKS1 (b) droplets were displayed below, with line analyses of fluorescence signal intensities along the indicated lines.

How do scaffolding proteins regulate the assembly of #presynaptic #ActiveZones? This study solves the structure of the liprin-α2/RIM1 complex & shows that it is essential for #synaptic transmission and LLPS-dependent coupling of Ca2+ channels & synaptic vesicles @plosbiology.org 🧪 plos.io/3Tj5CX7

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System (Cell 166, 209–221; June 30, 2016)

Super impressive!!

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System: Cell www.cell.com/cell/fulltex...

Towering behavior and collective dispersal in Caenorhabditis nematodes Perez et al. report that self-assembling nematode towers occur in nature and can function as collective dispersal structures. Using Caenorhabditis elegans, they establish a tractable empirical model t...

Very cool discovery!!

Towering behavior and collective dispersal in Caenorhabditis nematodes: Current Biology www.cell.com/current-biol...

Step by step process for peer review, which suggest the reviewer consider abstract, display elements, to results/methods, introduction, discussion, overall message, and then prepare the review

From novice to expert: preparing your peer review

A toolkit to train peer reviewers from mBio

journals.asm.org/doi/10.1128/...

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25 Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...

Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60

Identification of a large anion channel required for digestive vacuole acidification and amino acid export in Plasmodium falciparum Malaria parasites survive in red blood cells by breaking down hemoglobin in their digestive vacuole (DV). This study identifies a new large anion channel, BVAC, as responsible for DV acidification, en...

#Malaria parasites survive in red blood cells by breaking down hemoglobin. This study identifies a new large anion channel, BVAC, that enables hemoglobin digestion and amino acid transport in Plasmodium falciparum. 🧪
plos.io/45pxErx

The gut-brain axis next dimension
Resident T cells in the brain and its subfornical organ (SFO) that regulate eating and drinking
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling - Nature Communications The authors show that in C. elegans, Vitamin B12-driven changes in neuronal methionine cycle trigger a neuron-gut signalling axis, involving serotonin and neuropeptide secretion that modulate stress t...

www.nature.com/articles/s41...

Selected frames of a live-cell imaging time-course experiment. A single cell is shown, co-expressing PEEL-1::eGFP and PMPL-1::mCherry. The nucleus is labeled (“N”). t = 0 is 16 hrs after transfection. Acute swelling can be seen (t = 2 hr 30 min), followed by a transient blob or protrusion (arrow) jetted out by the cell (t = 4 hr 15 min) and later reabsorbed (dotted arrow) (t = 4 hr 20 min). Scale bar = 10 µm.

#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN

Postdoctoral Associate in IBD genetics in C. elegans and organoids Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Opening for a #postdoc in the lab available immediately. Please spread the word.

DETAILS HERE: jobrxiv.org/job/baylor-c...

cc: #academicJobs #postdocJobs #microbiome #Celegans #organoids #IBD #PathSky #Medsky #AcademicSky 🧪 🧬 🦠

What is life?
Find out from Nobel laureate Paul Nurse as he explores 5 big ideas in biology!

Join us for a public lecture at the Homi Bhabha Auditorium on May 30, 2025 (Friday).

Open to all (photo ID required)

#TIFRScience #PublicLecture #ScienceForAll #NobelLaureate

Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature Aging Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...

Beautiful work from the Murphy lab!!

www.nature.com/articles/s43...

Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species One avenue to better understand brain evolution is to map molecular patterns of evolutionary changes in neuronal cell types across entire nervous syst…

Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species

www.sciencedirect.com/science/arti...

Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation Cells reallocate their limited energy for cellular maintenance in response to nutrient scarcity at the expense of other processes, but how this trade-off is achieved remains unknown. These authors sho...

#RNAExosome #RNA #Starvation
doi.org/10.1371/jour...

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles Caenorhabditis elegans FLWR-1/Flower is required for efficient synaptic vesicle recycling and does so through a functional and possibly direct physical interaction with the plasma membrane Ca2+ ATPase...

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

elifesciences.org/articles/103...