📣 Happy to share our review on host-microbiome genomics!

We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes

Out now in Nature Reviews Genetics👇

www.nature.com/articles/s41...

Who's taking a Post Graduate course today? So much science to be shared! #ATS2025 #RCMBatATS

Happy World #sarcoidosis day! Will you #saysarcoidosis with us? #raiseawareness #foracure #forourpatients

STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders STING signaling in the innate immune system is well known for its role in the antiviral type I interferon response. Tang et al. find that STING acts as an immune sensor of lysosomal activity. When the...

#WeekendRead! #NotOnlyInterferons! @nanyanlab.bsky.social &co show @cp-molecularcell.bsky.social that other than inducing pathogenic IFNs in lysosomal storage disorders, STING also play protective functions as a proton channel activating TFEB & inducing lysosomal repair www.cell.com/molecular-ce...

So excited that our study made the cover of Nature Genetics this month!

It's a black and white paper header for a short communication, and I've copied the text below. Please stop reading if you don't want the literal copy to be read to you. "Naturwissenschaften (2003) 90:495–500 DOI 10.1007/s00114-003-0473-9 SHORT COMMUNICATION B. M. Rothschild · D. H. Tanke · M. Helbling · L. D. Martin Epidemiologic study of tumors in dinosaurs Received: 16 June 2003 / Accepted: 29 August 2003 / Published online: 14 October 2003 Springer-Verlag 2003"

One of the amazing things about science is we will never run out of mysteries.

Take "Naturwissenschaften (2003) 90:495–500", which performed a survey of 10,000 dinosaur fossils for evidence of tumors in the bone.

I was prepared for yes, no, but what I wasn't prepared for was:
"only in hadrosaurs."

Program committee working on planning for #SCCM2026 in Chicago! #SCCM2025 #PedsICU

My fellow made this teaching tool to teach our residents about choosing IV access and I am obsessed.

Sharing this official @atscommunity.bsky.social statement I was proud to be a part of. My takeaway: We need to standardize reporting and understand the impact of incidental findings in lung cancer screening. And also harness their findings for CVD prevention.

www.atsjournals.org/doi/10.1164/...

ICU ID - Pneumonia:

Since we are still facing a tsunami of respiratory tract infections, it's a good idea to review the 2023 clinical practice recommendations for diagnosis, empirical treatment, & antibiotic therapy for severe community-acquired pneumonia (sCAP)

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Hi #MedSky #ImpSci. I'm hiring a new staff scientist in my lab based in Seattle. We do #healthequity research in tobacco cessation, lung cancer and lung cancer screening. Please share with your networks and reach out directly if interested!

careers-fhcrc.icims.com/jobs/29239/j...

Energy we need

Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses.

A benefit of prior vaccination when there's a breakthrough infection: putting the brakes on a maladaptive innate immune response
www.science.org/doi/10.1126/...

The fungal microbiota modulate neonatal oxygen-induced lung injury - Microbiome Background The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity...

After 7 years of work and 1.5 years winding its way through publication, the paper I’ve wanted to share with you all for so long is finally out in @microbiomej.bsky.social

microbiomejournal.biomedcentral.com/articles/10....

#neosky #medsky #scisky #microbiome #fungi #mycobiome #newPI #science

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...

wow I’ve always wondered about this and never got a good explaination. #EMIMCC

How a heart medication—digoxin—might help prevent cancer spread by dissolving clusters of circulating tumor cells
www.nature.com/articles/s41...

A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls

www.nature.com/articles/s41...

Not a lot of surprises in this study but nice to see the data! 60% weaned off and 63% of those survived. Cardiac arrest before VA-ECMO associated with failure to wean, lactate clearance within 24 hours associated with success and CRRT & bleeding associated with death.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future:

Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...

Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study RSV vaccination was effective in preventing RSV-related illness, including associated health-care use, in adults aged 60 years and older during the 2023–24 respiratory illness season, supporting curre...

In a cohort of over 146,000 veterans RSV vaccine effectiveness was estimated at 78·7% (72·2–84·8) against RSV-associated emergency department or urgent care encounters, and 80·3% (65·8–90·1) against RSV-associated hospitalisation.
The #vaccines work.🧪#IDSky
www.thelancet.com/journals/lan...

We’re all in the bad place but my collaboration with NIH/NCI researchers has been published.

How to keep warm in the chill! The microbiome of some arctic worms protects them from the freeze by making cryoprotective compounds including the polyamine spermidine. 🧪

Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenito...

#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...

RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.

This epic study, which took more than three years to get published, deserves special consideration.

#immunology
#microbiome
#allergy

I keep my work separate from other things like reviews or other peoples manuscripts

My folders are grants, manuscripts, reviews, letters, projects, lab.work, conference notes, bronchoscopy, cv, manuscript.read.dump - then sub folders organized by year - month - committee or group - subject

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

Some cool immunology of gut lung axis showing the ying & Yang of a gut commensal protozoa Tritrichomonas musculis -drives eosinophilia in lung which dependent on ILC2 cells. This is good for protecting against dissemination of TB infection BUT less good for allergy symptoms which can be worsened🧪

#MedSky #Rheumatology

incoming rheumatology fellow at @uwdeptmedicine.bsky.social