Game of microbes: a wildling’s guide Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure and interactions with commensal and pathogenic microorganisms. In contrast, wild mice encounter diverse microbial environments, undergo natural selection, and rely on robust immune responses for survival. Consequently, lifelong microbial exposure is a key driver in shaping mammalian physiology, establishing the need for naturalizing rodent models in biomedical research. By defining the concepts of ‘microbial self’ and ‘microbial nonself’, we propose a four-step guide for establishing a multigenerational wildling colony that accounts for both microbial self and microbial nonself. This reestablishes the common biological link shared by all free-living mammals, thereby improving the comparability between murine and human studies.

Game of microbes: a wildling’s guide

Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

Most successful University of Excellence - In the atrium of the rectorate building, University members watched with bated breath as the decision on excellence was announced.

Most successful University of Excellence - Rector Hoch, together with the Rectorate and hundreds of guests, burst into cheers when the decision was announced.

Great news—We remain the most successful German University of Excellence! With eight Clusters of Excellence and funding secured until 2033, we’re moving closer to our goal of establishing our Uni permanently among the best universities in the world: www.uni-bonn.de/en/news/040-...
© VL/Uni Bonn

Cover: Electron micrograph depicting a neonatal hepatocyte densely filled with glycogen, essential for sustaining energy after birth. Nuclei are pseudocoloured in purple, mitochondria in red and glycogen particles in yellow. Serving as a symbolic representation, the image reflects the study's discovery that neighbouring macrophages (Kupffer cells) help maintain balanced neonatal hepatocyte glycogen metabolism. See Research Article by Makdissi et al. (dev204962).

Issue 2 is complete!

On the cover: Electron micrograph depicting a neonatal hepatocyte densely filled with glycogen (yellow). Nuclei (purple) and mitochondria (red) pseudo-coloured as well.

See the Research Article by Nikola Makdissi et al. from @masslab.bsky.social lab: doi.org/10.1242/dev....

Figure 3 - KOSpi1 hepatocytes contain less glycogen storage at birth. (A) Representative PAS (purple)-Hematoxylin (H, blue) staining of WTSpi1 and KOSpi1 livers at P0. Scale bars: 200 µm. (B) Scheme indicating how PAS staining intensity was quantified using Fiji. (C) Normalized PAS signal intensity of WTSpi1 and KOSpi1 livers at P0. Circles represent individual mice. n=3-4 per genotype from 2 independent litters. Paired Student's t-test. Data are shown as mean±s.d. (D) Glycogen levels measured on whole liver lysates of WTSpi1 and KOSpi1 P0 livers. n=5 per genotype from 3 independent litters. Values were normalized per litter. The whiskers represent the 5-95% percentile, the box extends from the 25th to 75th percentiles and the horizontal line represents the median. Cross indicates the mean. Mann–Whitney test. (E) Representative transmission electron micrograph from WTSpi1 and KOSpi1 livers at P0. n=3 per genotype from 2 independent litters. GP, glycogen particle; N, nucleus. Scale bars: 5 µm.

Inadequate imposters: Kupffer cells influence liver metabolism

This Research Highlight showcases work by Nikola Makdissi, Daria J. Hirschmann, Elvira Mass (@masslab.bsky.social) and colleagues

journals.biologists.com/dev/article/...

Photo of the researchers Prof. Florian Mormann and Dr. Marcel Bausch.

🧠 #ScienceSnack: The human brain must be able to link memories to their circumstances. Bonn Researchers have discovered two different neuron groups our brain uses to store content and context separately. Findings have been published in @nature.com. www.uni-bonn.de/en/news/004-...
© UKB/A. Winkler

Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper!

Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.

🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG

🚨 Postdoctoral Opportunity for Female Scientists🚨

The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists

Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...

#MicroSky 🧪

#PostDoc @univie.ac.at

🧬🍽️ Your macrophages may be carrying your mother’s metabolic history!
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming

Fresh from Elvira Mass Lab @masslab.bsky.social. We are happy to share our thoughts on how maternal malnutrition can shape the development of offspring tissue-resident macrophages during early development. Happy reading!

#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/...

📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25

Characterization of the mammalian prodefinitive angio-hematopoietic lineage The identification of mammalian prodefinitive angio-hematopoietic progenitors clarifies early hematopoiesis and macrophage development.

Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells.
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏

Interested in #macrophages? Don't forget the check out this Seminar Series 👇

The Vienna BioCenter PhD Program application deadline is approaching: October 10!

Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!

training.vbc.ac.at/phd-program/

#PhD #LifeSciences

🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de

Had the wonderful opportunity to present our data on the effect of microplastics on macrophages at #EMDS2025 ! Such a beautiful venue 🤩 @masslab.bsky.social

Flyer advertising the BonnBrain Conference 2026, "From Genes to Circuits and Behavior".

Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...

🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

Come be my colleague! We have three open positions at the Assistant/Associate Professor level for candidates in all areas of the biological sciences.

www.imperial.ac.uk/jobs/search-...

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

Setting the table for immune tolerance Interaction between breast milk antibodies and gut microbes shape immune responses during weaning

Out today! www.science.org/doi/10.1126/... From @kknoop.bsky.social & myself on early life immune development & the beautiful publication from Megan Koch & M Shenoy www.science.org/doi/10.1126/... Take home message: timing of early life exposures, milk IgG here, is critical for immune development.

COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586. Illustration: Rioka Hayama

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!

scim.ag/3UqRrA6

Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience

With the great @rebeccalevymdphd.bsky.social

🧠 New book chapter out!

We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.

🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...

4/Together, these studies highlight the evolutionarily #conserved and multi-organ impact of maternal diet on offspring health and disease susceptibility.

Huge thanks to Seyhmus Bayar and our collaborators for their fantastic work!
@for5775.bsky.social

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

3/ This work builds on our previous findings published in @nature.com (Huang et al., 2025), where we showed that yolk sac-derived Kupffer cells mediate fetal liver programming in obese pregnancies, driving fatty liver disease in adulthood (www.nature.com/articles/s41...)

2/In this study, we uncover how maternal diet in flies(corresponding to maternal obesity in mammals) disrupts #neuronal integrity and #immune function in offspring. We identify axon #degeneration and shortened #lifespan, linking maternal overnutrition to long-term health consequences.

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…

1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo

#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

Research Associate in Mucosal Immunology :Manchester

The fantastic Menon Lab (@madhvimenon.bsky.social) in the @lydiabeckeriii.bsky.social in Manchester are hiring!!
🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨

www.jobs.manchester.ac.uk/Job/JobDetai...

Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky