Peering into cancer cells to understand links between inflammation and tumour growth Air pollution, UV light and bacteria are just some of the external inflammatory triggers linked to cancers. But could tumours themselves also be driving dangerous inflammation?

Tumors drive #inflammation? Tumor cells shape microenvironment →promoting growth. e.g., #inflammation damages the #gut protective epithelial barrier, → ↑ inflammation in a harmful feedback loop. bit.ly/4sC3Yiy [open access]

Exposure of human lung #adenocarcinoma epithelial cells (#Calu-3) to cigarette smoke extracts→ #inflammation+↑ #DNA double strand breaks. #e-cigarette vapor no effect. e-cigarette vapor may exert less harmful effects on lung #epithelial cells compared to cigarette smoke. bit.ly/4tEa3vO

Mediterranean diet, #probiotics, and #fecal microbiota transplantation → #gut–brain axis → ↆ #neuroinflammation→ ↑ #cognition, #memory and executive function. bit.ly/4m02VYf [open access] bit.ly/3Qasn15

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

Chronic #gut #inflammation → alters colonic #stem cells →
↑ #AP-1 transcription factors→ tumor growth; persists for 100 days after “resolution”. bit.ly/4th89kP

Exploring Sex-Based Mechanisms of Inflammation and Neurodegeneration in Multiple Sclerosis - Stephanie Buxhoeveden, Theresa Swift-Scanlan, Myla D. Goldman, Ryan Canissario, Unsong Oh, 2026 Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by both immune-mediated inflammation and progressive n...

#Multiple sclerosis: Females more often present with ↑ #inflammation, males ↑ #neurodegeneration and disability progression. A review. bit.ly/40EdIgU

#Inflammation from gut #mcirobiome affects brain signaling via the #vagus nerve, linking gut health to #cognition. Altering composition can reverse cognitive decline in aging mice, enhancing memory formation. stanford.io/4rysCQz go.nature.com/4sPbw1W [open access].

People with chronic #pain → ↑ developing hypertension, partly explained by #inflammation and #depression. bit.ly/4lppLYK bit.ly/3P4n9DO

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from.....

#Rheumatoid arthritis -induced #dysbiosis of the #periodontal #microbiome→ periodontal inflammation → periodontitis-driven exacerbation of systemic #inflammation. bit.ly/4chLQWT [Open Access]

Eating More Ultra-Processed Foods Raises Heart Disease Risk by Nearly 50% Eating more ultra-processed foods may raise heart attack and stroke risk by nearly 50%.

High consumption of #ultra-processed foods → ↑ #hs-CRP [#inflammation]. bit.ly/3OvVFGP and 47% ↑ of #CVD and may contribute to ↑ risk of gastrointestinal diseases. bit.ly/4kPVWjN bit.ly/3OtW2Se

When attacked by the same virus, individuals produce #antibodies that target different parts of that virus. For a given #virus, some antibodies increase with #age while others decrease, depending on the viral fragment targeted. bit.ly/40kYPzG bit.ly/4rlralr [open access]

In older individuals, ↑ #inflammation and lower levels of #antioxidant assoc. w poorer #sleep. [open access] bit.ly/4cvAxKA bit.ly/4aI3kJI

Respiratory virus immune response in the aged host - Immunity & Ageing Immunity & Ageing - Viruses are a major cause of acute respiratory illness in older adults and pose a substantial burden as the elderly population continues to grow. In the current COVID-19...

#Aged host: Respiratory virus immune response [a review]. Aged mice ↑ expression of #inflammatory genes. Distinct changes in the inflammatory profile and gene expression signature of monocytes and macrophages in the aged host, particularly in the #lung microenvironment. bit.ly/4rQ65zz

Repurposing “Bad Cholesterol” to Precisely Target Inflammation in Atherosclerosis Professor Lisa Volpatti developed a targeted approach that directs anti-inflammatory proteins to diseased arteries, reducing immune cell activity and improving therapeutic effectiveness.

Targeted delivery that directs #IL-10 to #atherosclerotic #plaques with precision, modulates #inflammatory pathways. bit.ly/3ZgeUq5 go.nature.com/3OoyNsy

Key Role of Pro230 in the Hinge Region on the Architecture and Function of IgG1 Immunoglobulin G (IgG) is a multifunctional glycoprotein essential for immune defense and widely used as a therapeutic due to its antigen specificity and effector functions. However, the inherent flex...

Deleting a single amino acid in #IgG lower hinge alter sits assembly and immune signaling, e.g. impair interactions with #Fcγ receptors. bit.ly/4rsdrJo [open access]

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Cytosolic nucleic acid sensors contribute to pathogenic and autoinflammatory inflammation; however, little is known about the metabolic adaptations that they induce. Dunphy et al. find that these path...

Virus →#IFN-1→ ISG15. ↆ #mitochondrial membrane potential → ↑ mitochondrial fragmentation. ↆ inflammatory gene expression→ ↆ #inflammation and ↑ clearance of tissue damage. bit.ly/4qNGCq3 [open access].

#Exercise ↑ FOXO [#longevity’ genes and #anti-inflammatory] →ↆ #DEAF1. ↆ DEAF1 → muscle cells regain their ability to recycle damaged parts and stay healthy. Exercise helps restore homeostasis within muscle cells and keeps muscles stronger for longer. bit.ly/49PVRaU

Inflammatory Factors and Chronic Rhinosinusitis: An Umbrella Review Chronic rhinosinusitis (CRS) is a common inflammatory disorder of the nasal mucosa and paranasal sinuses characterized by persistent sinonasal symptoms and objective endoscopic and imaging evidence of...

Three immune-inflammatory patterns differ: in sequence of the inflammatory mediators, the immune cell populations involved, and the associated physiologic functions in #rhinosinusitis. bit.ly/4b3Igiv [open access].

Inflammation PET and plasma neurofilament light predict survival in people with progressive supranuclear palsy Shapiro et al. report that inflammation PET signals in subcortical regions and plasma neurofilament light levels are complementary prognostic biomarkers in

Progressive supranuclear palsy (#PSP) → atrophy and #inflammation of the brainstem, the basal #ganglia and, to a lesser degree, the #cortex. ↑ subcortical neuroinflammation→ assoc. with shorter survivals. bit.ly/4qj4hyr [open access]

The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis Gut bacteria are important in causing inflammatory bowel diseases. By combining the results from published studies we have identified the key changes in these bacteria that might help us develop new d...

ↆ anaerobes and ↑ of oxygen-tolerant, orally associated #gut #microbiome signatures in treatment-naïve new-onset #IBD. Migration of bacteria from the mouth to the gut may play a key role in triggering #inflammation. bit.ly/49tcRU1 bit.ly/4puJkPW

Progressive #MS →hallmark of grey matter injury = compartmentalized #inflammation (CI) of the #leptomeninges. In vivo, 800x ↑ #CXCL13 + significantly ↆ BAFF assoc. w CI . Ratios → grey matter injury.bit.ly/4q0kxUZ go.nature.com/3Yk0AfL

Neurobehavioural links from infant screen time to anxiety Higher infant screen time is linked to accelerated topological maturation of the visual and cognitive control networks, leading to prolonged decision latency and increased adolescent anxiety. Sensory ...

#Infancy particularly sensitive period for #screen exposure. Exposure <2 yrs → ↑#brain maturation, ↆ decision-making, and ↑ anxiety by #adolescence. Shared reading 3yrs ↆ the brain- alterations suggesting a protective effect. bit.ly/3MZXdZ2 [open access]

P1223 Maternal dietary patterns during pregnancy and offspring’s risk of paediatric Inflammatory Bowel Disease - a cohort study AbstractBackground. The association between maternal dietary patterns during pregnancy and offspring’s risk of paediatric-onset inflammatory bowel disease

Diverse diet during #pregnancy= ↑ meat, fish, vegetables, legumes, fruits, potatoes→ ↆ risk of #IBD vs Western-style diet. bit.ly/4aCM2z5 go.nature.com/49cY8fP

Inflammation in areas of fibrosis precedes loss of kidney function in lupus nephritis Background Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells but typically regarded as non-specific ‘scar reaction’. This study aimed to investigate the relationship b...

#Inflammation in areas of #fibrosis precedes loss of kidney function in #lupus nephritis bit.ly/4pFLT2q [open access]

Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...

Long #COVID (n=142)→ persistent activation of chronic #inflammation. Including proinflammatory #cytokine signaling, #complement activation, #metabolic dysregulation and immune #exhaustion. Suggestion of link between metabolic dysregulation and inflammation. go.nature.com/48UfU7B
[open access].

The neural basis of endogenous reinforcement learning.

Vividly imagining a positive interaction with someone can increase how much you like them — and alter how your brain stores information about that person. (Similar to those seen when people learn from real rewarding experiences.) bit.ly/4ac9dAe go.nature.com/48SDuS9 [open access]

Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study | Circulation: Cardiovascular Imaging BACKGROUND: Psychosocial stress is linked to the development of cardiovascular disease, with a more pronounced impact in female participants. This study investigates sex differences in the association...

#Women w psychosocial stress, e.g., #caregiving and lack of emotional support→ early heart tissue changes assoc. w #CVD. MRI scans →signs of #inflammation. Not observed in males. bit.ly/4pQUzCJ bit.ly/4iKH9Wz

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin

#Adipocytes → #obesity-associated chronic #inflammation and metabolic disorders via two @#β2-microglobulin-dependent mechanisms. bit.ly/4poJMA9 [open access]

Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction - Immunity & Ageing Aging has profound effects on whole-body homeostasis. With age, adipose tissue undergoes marked alterations in immune microenvironment and distribution as well as a loss of immune and metabolic capaci...

#Age-related #inflammation disrupts #adipose tissue #homeostasis, interferes with its metabolic functions, → age-related diseases. bit.ly/4obug9a [open access

Resveratrol–Copper Combination Suppresses Glioblastoma Growth and Restores Immune Function A small but powerful clinical trial reveals that resveratrol and copper can reduce tumor growth, restore immune function, and clear harmful DNA fragments in glioblastoma—without adverse effects.

Oral administration of #resveratrol and #copper may have a profound effect on the aggressive phenotype of #glioblastoma. [5.6 mg of resveratrol and 560 ng of Cu 4x/day for an average of 11.6 days]. How about other neoplasms? bit.ly/49tSXtQ go.nature.com/4oPpuQ1 [open access]

Systematic profiling reveals betaine as an exercise mimetic for geroprotection Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

#Exercise→#betaine→#inflammation, muscles, heart, genes, proteins shift over weeks, not minutes. ↑ betaine →ↆ inflammation, cellular #aging ↆ, ↑ energy expenditure, ↑ gut bacteria→ ↑ immune strength and antioxidant activity. bit.ly/446OZUp bit.ly/47LKoJL