HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs, known as melanosomes, that directly engage and impair CD8+ T cell receptors.

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

Preprint and the website by @dingdingpeng.the100.ci and @vincentab.bsky.social are great, and I got inspired to illustrate Bayesian workflow for model checking and comparison *before* model interpretation following their friendship importance example users.aalto.fi/~ave/casestu...

@natcomms.nature.com

We fellow up upon this work and furthermore uncover intriguing insights about PILT cells development and functional commitment using single-cell RNA sequencing and artificial thymic organoids.

We previously described peptide specific PLZF+ innate like T cells (PILT cells) as a new member of the innate-like T cells www.nature.com/articles/s41...

Developmental features and unique characteristics of peptide-specific PLZF+ innate-like T cells in mice - Nature Communications Development of T cells in the thymus results in small populations of innate like T cells. Here the authors characterise a population of innate-like T cells in mice engineered to enable MHC class I exp...

🎉 Exciting news! Our paper has finally been published in Nature Communications!

If you’re interested in innate-like T cells, you’ll find this especially exciting.

www.nature.com/articles/s41...

#immunology #bioinformatics #innate_like_T_cells #iNKT #MAIT

I have a brilliant scientist in my group. She proposed we approach our science as a once in a lifetime opportunity. So, let's do the risky experiments, think deeply, write beautifully, and show reverence to the most awe-some career

@inikon.bsky.social

Hello, Bluesky! ☀️

We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.

Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

The T cell receptor sequence influences the likelihood of T cell memory formation The human immune system contains a vast repertoire of somatically recombined T cell receptor (TCR) sequences. To connect TCR sequence to T cell function, Lagattuta et al. analyze the paired αβTCR and ...

The T cell receptor sequence influences the likelihood of T cell memory formation

www.cell.com/cell-reports...

More on #OpenAI and #DeepSeek

This Deepseek thing is like when Godzilla show up to defeat a more evil kaiju

This has been my opinion regarding the use of GPT and likes for writing.

"Historians have a word for Germans who joined the Nazi party, not because they hated Jews, but out of a hope for restored patriotism, or a sense of economic anxiety,or a hope to preserve their religious values, or dislike of their opponents, or raw political opportunism, or convenience, or ignorance, or greed. That word is Nazi. Nobody cares about their motives anymore. " ~ Julius Goat

yes.

Leave Greenland, Denmark, and Panama the fuck alone.

CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition and ligand discrimination, yet their magnitude, frequency, and impact r...

#Immunosky CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions www.biorxiv.org/content/10.1...

EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication Precise control of gene expression is essential for cellular function, but the mechanisms by which enhancers communicate with promoters to coordinate this process are not fully understood. While seque...

EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication

www.biorxiv.org/content/10.1...

#Immunosky help!

Avez-vous une minute pour aider cette campagne? Support IMGT Nomenclature for Standardized Naming of Immunoglobulins and T-Cell Receptors

Support IMGT Nomenclature for Standardized Naming of Immunoglobulins and T-Cell Receptors

Breaking the mold: Unconventional T cells in cancer therapy Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy. This commentary will assess these advances and translational possibilities in the field.

Breaking the mold: Unconventional T cells in cancer therapy: Cancer Cell www.cell.com/cancer-cell/...

Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay www.biorxiv.org/content/10.1101/2024.12....

The applying of immuno-RCA for the high-sensitivity detection of the ABO blood group antibodies on the printed glycoarray www.biorxiv.org/content/10.1101/2024.12....

Integrative mapping of human CD8+ T cells in inflammation and cancer - Nature Methods scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8+ T cell atlas with integrated T cell receptor data.

Integrative mapping of human CD8+ T cells in inflammation and cancer

#Immunosky

Dysfunctional bronchoalveolar effector memory CD8+ T cells in tuberculosis-exposed people living with antiretroviral-naïve HIV infection Immunology; Virology

Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author
@maphemthembu.bsky.social

A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses
#HIVSky #IDSky #ImmunoSky

www.cell.com/iscience/ful...

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection IL-17A–secreting MAIT17 cells can convert to IFN-γ–producing MAIT1 cells, boosting protection against microbial infection.

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection

Transitioning to e-cigarettes restores the immune response to house dust mite in cigarette smoked mice. www.biorxiv.org/content/10.1101/2024.12....

Vgamma1+ gammadelta T cell-derived IL-4 initiates CD8 T cell immunity www.biorxiv.org/content/10.1101/2024.12....

🧬

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing α/β T cells are key players in adaptive immunity. The specificity of T cells is determined by the sequences of the hypervariable T cell receptor (TCR) α and β chains. Although bulk TCR sequencing offe...

Should I go for Single-Cell or Bulk TCR sequencing?

That’s a question often asked by researchers that want to start sequencing their T-cells.

What if you do not need to make that choice anymore? Enter TIRTL-seq from @pgtimmune.bsky.social lab!

www.biorxiv.org/content/10.1...

#Immunosky

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Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

Our new work!

We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...