🔥Hypovolemia → Na+ retention → volume restoration 💧🧂

https://youtu.be/H_Ueh1PfS7M

How the body senses ↓ effective circulating volume & activates #RAAS, SNS, #aldosterone to reclaim Na+

👀Immersive learning www.abckidney.com

#NephSky #MedEd #RAAS #Physiology

🔥Hypovolemia → Na+ retention → volume restoration 💧🧂

https://youtu.be/H_Ueh1PfS7M

How the body senses ↓ effective circulating volume & activates #RAAS, SNS, #aldosterone to reclaim Na+

👀Immersive learning www.abckidney.com

#NephSky #MedEd #RAAS #Physiology

Figure 2. xxx. Waterfall plot of plasma aldosterone concentrations after the seated saline suppression test measured using steroid immunoassay (A) and liquid chromatography/tandem mass spectrometry (B). Saline-suppressed aldosterone levels are ordered from lowest to highest with each bar representing an individual participant and colored according to the presence of lateralizing PA (defined by adrenal vein sampling using a lateralization index ≥3:1). The horizontal dashed lines in A represent aldosterone cutoffs of 140 pmol/L (5.0 ng/dL) and 280 pmol/L (10.1 ng/dL), measured by immunoassay, for disease detection suggested by guidelines that were current during the study;5 in B, the horizontal dashed line corresponds to an aldosterone cutoff of 162 pmol/L (5.8 ng/dL), measured by liquid chromatography/tandem mass spectrometry, which has been suggested as an optimal cutoff.22.

the Saline suppression test is pretty useless to decide if you should do AVS

source: pubmed.ncbi.nlm.nih.gov/41582811/ from colleagues in Alberta

@ahajournals.bsky.social

#hypertension #aldosterone

At Mineralys, we are advancing lorundrostat, a highly selective aldosterone synthase inhibitor, designed to directly target aldosterone production and explore a more precise approach to blood pressure biology.

#Hypertension #Obesity #CardiometabolicHealth #Aldosterone #BloodPressure

New review to read! #Aldosterone synthase inhibitors across the translational spectrum.

➡️ Excess aldosterone is a key driver of cardiovascular, renal, and metabolic injury.
➡️ Mechanistic foundations and emerging clinical applications.

🔗 doi.org/10.1111/joim.70061

Endocrine Grand Rounds: Dr Sophie Ambruso from #Nephrology presented on chronic kidney disease and recognizing and treating the direct and indirect effects of #aldosterone.
@cudeptofmedicine.bsky.social

a woman in a red dress is holding a microphone in her hand and dancing on a stage . Alt: a woman in a red dress is holding a microphone in her hand and dancing on a stage .

Who gets a renin checked?

#aldosterone #Hypertension

Aldosterone-targeted therapies: early implementation in resistant hypertension and chronic kidney disease Abstract. Treatment-resistant hypertension (TRH) often coexists with chronic kidney disease (CKD), and the presence of both conditions increases the risk o

Seems it is month to 🔦 on #Aldosterone #MR❤️

State of the Art Review by Prof Faiez Zannad & co-authors in
@escardio.bsky.social #EHJ👏

Aldosterone-targeted therapies: early implementation in resistant #hypertension & #CKD

academic.oup.com/eurheartj/ar...

We’re building @CortiCheck — the first real-time cortisol + aldosterone monitor. Game changer for adrenal health, stress, & rare disease care. You in, @mcuban?

#HealthTech #RareDisease #Cortisol #Aldosterone #CortiCheck

#Aldosterone alters cardiomyocyte states and changes cell-cell interactions, finally leading to atrial myopathy and atrial fibrillation.
www.ahajournals.org/doi/10.1161/... #afib Shout out to David Meral de.linkedin.com/in/david-mer...

Dr. Katherine Tuttle focuses her educational Grand Rounds talk on a reemerging topic: "New Approaches to Blocking #Aldosterone & #Angiotensinogen for #Hypertension or #CKD." #kidney #nephrology #nephsky
@uwmedicine.bsky.social

youtu.be/TeWkmCopuzk

Oral Sodium Loading Test Is More Sensitive Than Seated Saline Infusion Test to Confirm Overt Primary Aldosteronism AbstractContext. Primary aldosteronism (PA), a frequent but underdiagnosed cause of hypertension, is associated with a significant burden of cardiovascular

Oral sodium loading test is more sensitive than seated saline infusion test to confirm overt primary #aldosteronism: featured article in #JES. #OpenAccess
#adrenal #diagnosis #aldosterone @endocrinesociety.bsky.social
doi.org/10.1210/jend...

A 💫 finding of run-in phase of #ADVANCE-HTN Ph2b #RCT:
64% ppl with “uncontrolled” #hypertension got BP control in 3 wks through standard genericTx

#Aldosterone synthase blocker #lorundrostat 50 mg ⬇️BP at 8wks (w ⬆️K). 100mg: no evidence of added benefit
#ACC25
www.radcliffecvrm.com/video-index/...

The adrenal glands, located atop the kidneys, produce #Hormones such as #Cortisol, #Aldosterone & epinephrine, which regulate #Metabolism, immune function, #BloodPressure & stress response. Adrenal diseases occur when too much/not enough hormones are produced.

Insightful Editorial by Milton Packer cleaning up some myths on #Aldosterone and MR in heart failure treatment
www.sciencedirect.com/science/arti...

●膽固醇及荷爾蒙

研究顯示，血液中
總膽固醇的濃度
在冬天會來到高峰，
而膽固醇會減損
#內皮細胞 的功能，
進而造成血管硬化。

有研究指出，
一些和血管活性相關而引起血壓高的荷爾蒙，

例如： #醛固酮
（ #Aldosterone ），

正腎上腺素

（ #Norepinephrine ），
及 #腎素（ #Renin ），

在冬天會比夏天分別上升59%、19%，以及17%。

5種人需特別注意血壓變化