Centriole de la chatte
Un centriole est une structure cylindrique à l'intérieur des cellules animales, jouant un rôle clé dans la division cellulaire et l'organisation du cytosquelette. #Centriole #cellules #division #cytosquelette #structure
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
How does C2CD3 contribute to distal appendage formation in centrioles? @ebertiaux.bsky.social @centriolelab.bsky.social show that C2CD3 architecturally organizes the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
How does C2CD3 contribute to distal appendage formation in centrioles? @ebertiaux.bsky.social @centriolelab.bsky.social show that C2CD3 architecturally organizes the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
PCMD-1 stabilizes the PCM scaffold and facilitates #centriole separation, say Alina Schreiner, Tamara Mikeladze-Dvali @tdvalilab.bsky.social and colleagues: rupress.org/jcb/article/...
@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision
Schreiner, Mikeladze-Dvali et al. @lifescimunich.bsky.social show that CDK-1 primes PCMD-1 for PLK-1 phosphorylation. Mutations in PLK-1 docking sites impair SPD-5 binding, destabilize the PCM, and delay #centriole separation. rupress.org/jcb/article/...
#Centrosome #PCMstability #Celegans
In @jcb.org, Schreiner, Mikeladze-Dvali et al. show that CDK-1 primes PCMD-1 for PLK-1 phosphorylation. Mutations in PLK-1 docking sites impair SPD-5 binding, destabilize the PCM, and delay #centriole separation. rupress.org/jcb/article/...
#Centrosome #PCMstability #Celegans
The Unkempt RNA binding protein reveals a local translation program in #centriole overduplication. New study from Abraham Martinez, Chad Pearson and colleagues @cuanschutz.bsky.social: rupress.org/jcb/article/...
#RNAbiology #Cytoskeleton #Cancer #Centrosomes
Martinez, Pearson et al. @cuanschutz.bsky.social reveal that the RNA-binding protein, UNK, facilitates PLK4-induced #centriole overduplication and promotes centriole and centriolar satellite protein localization. rupress.org/jcb/article/...
#RNAbiology #Cytoskeleton #Cancer #Centrosomes
In @jcb.org, Martinez, Pearson et al. @cuanschutz.bsky.social reveal that the RNA-binding protein, UNK, facilitates PLK4-induced #centriole overduplication and promotes centriole and centriolar satellite protein localization rupress.org/jcb/article/...
#RNAbiology #Cytoskeleton #Cancer #Centrosomes
Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!
www.biorxiv.org/content/10.1...
A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀
Another wonderful #openaccess #review #article is now available in #CYTOSKELETON. "PLK4: Master Regulator of #Centriole Duplication and Its Therapeutic Potential". You'll find it here: onlinelibrary.wiley.com/doi/full/10....
A #new #FREE ACCESS mini #review #article is now available in #CYTOSKELETON. CEP72 Emerges as a Key Centriolar Satellite Protein in Health and Disease. Check it out here: onlinelibrary.wiley.com/doi/full/10.... #centriole #microtubule #cell #cellbiology
Happy #FluorescenceFriday🔬 🌈
Here's an #expansion microscopy image showing early stages of #centriole and #cilia biogenesis in a human airway multiciliated cell
HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al. show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects https://buff.ly/3XlIry1
Oh gosh... #CENTRIOLE
New: Iyer, Akhmanova et al reveal that two centriolar proteins, CP110 & CPAP, show antagonistic activities at #microtubule + ends. Together, they impart very slow but processive microtubule polymerization & their interaction promotes robust #centriole formation https://buff.ly/3WuSIaL
Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.
#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
Let's fly into the #centriole of #centrosome of live human fibroblast stained with 4-610CP-CTX (tubulin probe)! Enjoy #3D #STED image.
Need more information, read in @ChemicalScience: https://t.co/YALsGep1hl #GoLive #FluorescentFriday #TubulinThursday
