Blocking microglial reactivity via #purinergic receptors prevents subacute #cognitivedeficits after TIA ➡️ doi.org/10.1038/s44321-026-00397-6

By G. Llovera, @arthurliesz.bsky.social & colleagues @synergy-munich.bsky.social

Read related N&V by Kibin Shi & al 🗞️ doi.org/10.1038/s44321-026-00404-w

A newly engineered AAVT42 #vector delivers #BDNF more efficiently to #neurons and that long-term hippocampal BDNF expression reduces #NeuronalLoss and #CognitiveDeficits in #Alzheimers mouse models, supporting AAV-based neurotrophic therapy.

#OpenAccess: doi.org/10.1016/j.ge...

Sometimes family and friends deny, deny, deny, what is right in front of them. They say, "He (or she) is forgetful, that's normal."

But in the early stages people can be pretty good at covering up their #CognitiveDeficits. People only believe it when there's no choice.

#Voters didn't believe it.

This research letter reports that engineered #butyrate-producing #yeast J17 restores butyrate levels, reduces amyloid-β deposition, mitigates #neuroinflammation, and rescues #CognitiveDeficits in AD mice. #AlzheimersDisease

#OpenAccess #STTT: doi.org/10.1038/s413...

You May Want to Keep Your Head Out of the Game Call it soccer or call it football, heading the ball is associated with brain changes that can lead to cognitive deficits later on -- even among amateur players.

Heading a soccer ball is associated with brain changes that can even lead to cognitive deficits in amateurs. www.thedoctorwillseeyounow.com/content/spor... @columbiauniversity.bsky.social #header #soccer #kidssoccer #repetitivebraininjury #cognitivedeficits #brainhealth @einsteinmededu.bsky.social

Carbamazepine is able to reduce the seizures by 87% after chronic treatment in the KCNQ2-DEE mouse model.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #carbamazepine #chronictreatment #cognitivedeficits #DEE #KCNQ2

Neuroscientists identify a reversible biological mechanism behind drug-induced cognitive deficits Researchers found that methamphetamine and PCP cause a phenomenon known as neurotransmitter switching, impairing memory. This change is reversible, pointing to potential treatments for drug-induced cognitive deficits and related neuropsychiatric…

Researchers found that methamphetamine and PCP cause a phenomenon known as neurotransmitter switching, impairing memory. This change is reversible, pointing to potential treatments for drug-induced cognitive deficits and related… #Neuroscientists #DrugInduced #CognitiveDeficits #Methamphetamine #PCP

Statistica per la scienza:
- quanti di voi farebbero una roulette russa con questo tipo di arma?
Per chi ha risposto in modo affermativo alla prima domanda:
- Perché hai deciso di votare proprio #m5s?

#barillari #CognitiveDeficits