This review examines lysine #crotonylation (Kcr) as a widespread #PostTranslationalModification regulating gene expression, #DNArepair, protein stability, and disease, highlighting crosstalk with #acetylation and other PTMs as therapeutic targets.

Read: doi.org/10.1016/j.ge...

Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer | PNAS Posttranslational modifications (PTMs) on histones play critical roles in cellular processes, including gene expression and tumorigenesis. However,...

Epigenetics Update - Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer bit.ly/3IDQSAA

Lihui Wang reporting in PNAS

#Epigenetics #Crotonylation #Cancer
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Gain deeper insights into gene regulation; epigenometech.com

Protein lysine crotonylation in cellular processions and disease associations

A review on the role of protein lysine #crotonylation (Kcr) modifications in regulating different biological processes and in the #pathogenesis & progression of various human diseases, with insights on the potential of Kcr regulators as therapeutic targets. #medsky

#OpenAccess: buff.ly/0LWFx17

NAE1 (NEDD8 Activating Enzyme E1) K238 #Crotonylation - Gelsolin #Neddylation axis
⏫#CardiacHypertrophy

Cardiomyocyte Crotonylation⏫by
Angiotensin II
TAC
#HypertrophicCardiomyopathy

Crotonylomics
TAC🐭🫀
4724 crotonylated sites/1167 proteins

#CircRes 2024
www.ahajournals.org/doi/full/10....