If you are interested in knowing more about the derivation of fibrosis-associated endothelial cells in liver fibrosis then check out our new preprint #fluorescencefriday #endothelialcells #FAEC

Maybe I can entice you to take a look at the fancy full spectrum flow cytometry figures? There is more where that came from! #endothelialcells #vascularbiology #liver #fibrosis

Do also check out amazing videos of cortical actin dynamics in #zebrafish #endothelialcells such as this one! @riken-bdr.bsky.social

Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication

A comprehensive overview of the origins of #EndothelialCells in hypoxic & #TumorAngiogenesis, the key regulatory molecules, with discussion of the advances, challenges, and future directions of #AntiAngiogenicTherapy.

#OpenAccess: doi.org/10.1016/j.ge...

📣 EVBO Seminar this Wednesday with talks by
🔬 @gluxan.bsky.social
🧠 @lbejarano.bsky.social
🧬 Sébastien Dumas
Kindly supported by nanoEntek.
🗓️ Wednesday | 15:00–16:00 CET
💻 Online
I’m happy to chair and moderate and hope many of you can join us!
#EVBO #VascularBiology #EndothelialCells #Seminar

DTR-mediated endothelial cell ablation after DT administration. A) Immunostaining for GFP, DTR, and DAPI on liver, heart, and lung sections from Cdh5-DTRGFP mice. B) A schematic showing experimental design. One pulse of PBS/DT was injected at 6 weeks, and mice were sacrificed after 2 days. C) Survival of DT treatment- and ctrl-mice. D) Bright field of the liver from DT-induced and ctrl mice. E) Immunostaining for GFP on livers from PBS- and DT-treated mice. F) Immunostaining for GFP, VE-cad, Ter119, and DAPI on liver, heart, and lung sections from mice treated with PBS or DT shows a significant leakiness of blood cells (arrowheads) in DT-treated mice. G) Analysis of the Ter119+ erythrocytes in liver, heart, and lung sections per 20×field from different sections. H) Schematic model of DTR-mediated endothelial cell ablation and vascular leakage. Upon binding to its DT, the DTR expressed on endothelial cells triggers specific cell death pathways. This resultant endothelial cell loss disrupts the integrity of the vascular wall, leading to vessel rupture and subsequent extravasation of erythrocytes. Data are means ± SEM. n = 5 mice. The yellow scale bar represents 2000 μm. The white scale bar represents 100 μm.

Cell Regen Research | A new mouse model for precise endothelial cell ablation! 🩸Dual Cre/Dre logic activates DTR for precise vascular studies.
#EndothelialCells #GeneEditing

🔗 Full paper at: doi.org/10.1186/s136...

Learn more: www.neuromics.com/more-diabete...

#endothelialcells #diabetes #humancells #neuromics

🧭 #EndothelialCells are polarized against #BloodFlow direction ⤴️. #Centrioles are consistently upstream of the #nucleus. This polarity persists even in fixed tissue and could serve as a structural marker for flow direction. 📌
🧪🧵7/8

A schematic illustration of the neurovascular unit highlighting primary cilia in ECs.

😮Surprise: 🚶‍♀️🧠 #EndothelialCells (EC) have #PrimaryCilia facing the vessel lumen, but 🐁🧠 ECs don’t. ~18% of 🚶‍♀️🧠 ECs are ciliated, mostly in arteriolar-end capillaries. What do these #cilia sense in the 🩸?
🧪🧵6/8

Fat cells (in green) can receive mRNA and proteins from neighboring cells. Image Credit: Daeseok Kim, Touchstone Diabetes Center, UT Southwestern Medical Center.

In #FatTissue, neighboring cells lend a hand when critical #genes stop working. In PNAS Journal Club: https://ow.ly/Y6iC50XkuEa

#GeneticKnockout #EndothelialCells endocrinology #CellBiology #GLP1

This top-downloaded article from April 2025 reviews the origins of #EndothelialCells in #Angiogenesis and recent advancements in anti-angiogenic therapies, potentially enhancing the #Clinical treatment of solid #Tumors. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

#Angiocrine & #Pericrine signaling: how #EndothelialCells & #Pericytes drive cancer progression and therapy resistance

Hodivala-Dilke lab #PhysiolRev 2025
journals.physiology.org/doi/abs/10.1...

Anyone can share a reading link?🙏
Behind the paywall💰😩

Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation Nature Cardiovascular Research - Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify...

Great and unique resource for those who are interested in studying peripheral artery disease mechanisms 👇. Congratulations to Guillermo Turiel and huge thanks to all our collaborators @ethz.ch and Kantonsspital Baden. #PAD #endothelialcells #peripheralarterydisease
rdcu.be/eGpZI

Check out this review on tumor angiogenesis!
This article reviews the origins of #EndothelialCells in #tumor #angiogenesis, highlights key molecules and signaling pathways involved, and explores recent advancements in anti-angiogenic therapy. #medsky

www.sciencedirect.com/science/arti...

The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function | Journal of Applied Physiology | American Physiological Society The experimental aim of this study was to determine, in vitro, the effect of the non-nutritive sweetener erythritol on brain microvascular endothelial cell oxidative stress, nitric oxide (NO) and endo...

Recent study finds that the non-nutritive sweetener erythritol negatively impacts brain microvascular endothelial cell function, highlighting potential risks for brain health. More research needed! #Erythritol #BrainHealth #EndothelialCells

journals.physiology.org/doi/full/10....

High-Purity Production of Endothelial Cells from Human Pluripotent Stem Cells
Kamei, K.-i. et al.
Paper
Details
#StemCellResearch #EndothelialCells #HighPurityProduction

Left: Confocal image of a live zebrafish larva brain that has red fluorescent vasculature infected with green fluorescent Group B Streptococcus that is entering the brain through weakened vessels. Right: Confocal image from a live zebrafish larva brain showing a green fluorescent brain blood vessel infected with a blue fluorescent Group B Streptococcus (GBS) microcolony. The GBS microcolony has killed the endothelial cell that makes up the vessel, indicated by the red fluorescence from the propidium iodide (cell death stain) labeling.

How do group B #Streptococcus bacteria cross the endothelial cells of the blood-brain barrier cause #meningitis? This study shows that the #bacteria perforate and lyse #EndothelialCells in the brain #BloodVessels, facilitating brain invasion in #zebrafish @plosbiology.org 🧪 plos.io/4lb8a5U

Left: Confocal image of a live zebrafish larva brain that has red fluorescent vasculature infected with green fluorescent Group B Streptococcus that is entering the brain through weakened vessels. Right: Confocal image from a live zebrafish larva brain showing a green fluorescent brain blood vessel infected with a blue fluorescent Group B Streptococcus (GBS) microcolony. The GBS microcolony has killed the endothelial cell that makes up the vessel, indicated by the red fluorescence from the propidium iodide (cell death stain) labeling.

How do group B #Streptococcus bacteria cross the endothelial cells of the blood-brain barrier cause #meningitis? This study shows that the #bacteria perforate and lyse #EndothelialCells in the brain #BloodVessels, facilitating brain invasion in #zebrafish @plosbiology.org 🧪 plos.io/4lb8a5U

Left: Confocal image of a live zebrafish larva brain that has red fluorescent vasculature infected with green fluorescent Group B Streptococcus that is entering the brain through weakened vessels. Right: Confocal image from a live zebrafish larva brain showing a green fluorescent brain blood vessel infected with a blue fluorescent Group B Streptococcus (GBS) microcolony. The GBS microcolony has killed the endothelial cell that makes up the vessel, indicated by the red fluorescence from the propidium iodide (cell death stain) labeling.

How do group B #Streptococcus bacteria cross the endothelial cells of the blood-brain barrier cause #meningitis? This study shows that the #bacteria perforate and lyse #EndothelialCells in the brain #BloodVessels, facilitating brain invasion in #zebrafish @plosbiology.org 🧪 plos.io/4lb8a5U

Most read on Angiogenesis!

This review summarizes the latest findings on the origins of #EndothelialCells in #tumor #angiogenesis and explores the progress, limitations, and future directions of #AntiAngiogenicTherapy. #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand Bone-specific endothelial cells (b-ECs) uniquely express KITLG, which recruits c-Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the os...

Our new Advanced Science paper is out! We show that human bone-derived endothelial cells drive bone regeneration via KIT ligand expression, revealing a vascular niche role in skeletal repair.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#BoneRegeneration #KITLG #EndothelialCells

Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment - Nature Cardiovascular Research Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while simultaneously preventing iPS cell-...

New in ‪@natcardiovascres.nature.com‬. ETV2 guides endothelial cell fate by recruiting REST to repress alternative lineages. This paper offers new insights into EC specification using single-cell multi-omics. Glad to have contributed!
#ETV2 #endothelialcells #stemcells
www.nature.com/articles/s44...

#ThrowbackThursday in JHC: "Immunohistochemical and Morphometric Assessment on the Biological Function and Vascular Endothelial Cells in the Initial Process of Cortical Porosity in Mice With PTH Administration."

Click to read for FREE: bit.ly/4aB7tg5

#endothelialcells #bloodvessels

A protein link between brain diseases and leaky blood-brain barrier – BioNews Central Mutations in the TARDBP gene that reduce TDP-43 protein levels also impair the endothelial cells lining the blood vessels in the brain, which play a vital role in maintaining the blood-brain barrier—a protective shield that prevents harmful substance

#Mutations in the TARDBP gene that lower #TDP43 protein levels damage #brain #BloodVessel #EndothelialCells, disrupting the #BloodBrainBarrier and contributing to diseases like #Alzheimers, #FrontotemporalDementia, and #ALS.

Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets In the past 10 years, CRISPR-Cas9 has revolutionized the gene-editing field due to its modularity, simplicity, and efficacy. It has been applied for the creation of in vivo models, to further understa...

Targeting #Lung #EndothelialCells & #EpithelialCells through #LNPtechnology without off-target editing in the liver offers #DrugDevelopment pubs.acs.org/doi/10.1021/... @MJMitchell_Lab #LipidNanoparticles #Nanomedicine #TranslationalScience

It was a pleasure to host Dr. Hirschi as part of our Global Speaker Series. We thank her for sharing her expertise in #endothelialcells in a talk and in meetings with #regenmed focused faculty and trainees at #UofT and its affiliated hospitals.

Just published!🎉
Excited to present Pickering lab's work on @pnas.org
#IntussusceptiveAngiogenesis-On-A-Chip🤩

For 1st time in vitro, we rebuilt multicellular pillars composed of #EndothelialCells crossing a pressurized, flowing channel🤓

Kudos to our stellar Sabrina🌟
www.pnas.org/doi/10.1073/...

Good Morning sunshine......Will you be my friEnd(MT)? Sorry sometimes my obsession with pareidolia gets the better of me #vascularbiology #endothelialcells #EndMT #facesinthings 😍

Endothelial Cells Endothelial cells, including microvascular cells, from Neuromics, are utilized to study vascular biology. These cells are essential for researching the formation of blood vessels, vascular function, a...

Check out all our endothelial cells: www.neuromics.com/endothelial-...

#endothelialcells #COVID #diabetes

Endothelial Cells Endothelial cells, including microvascular cells, from Neuromics, are utilized to study vascular biology. These cells are essential for researching the formation of blood vessels, vascular function, a...

Check out our cells: www.neuromics.com/endothelial-...

Check out customer publications: www.neuromics.com/endothelial-...

#DiabetesResearch #EndothelialCells #Neuromics #DiabeticRetinopathy #MedicalScience