📝 Online now - the Review "Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier" from Edmund Kunji (@mrc-mbu.bsky.social) and co.

#SLC54 #MPC #EnergyMetabolism #MembraneProteinStructure #StructureBasedDrugDesign

Read it here 👉 authors.elsevier.com/sd/article/S...

This review highlights recent advances in #EnergyMetabolism, detailing key pathways like #glycolysis, #OXPHOS, and #FAO, their dysregulation in diseases, and emerging strategies for precision treatment. #multiomics #CRISPR #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

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Glia feed neurons upon starvation: our 2022 Nature Metabolism paper revealed a glia-to-neuron ketone body shuttle 💪
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www.nature.com/articles/s42...

Job Alert

Researcher (Medical doctor) (m/f/div) in the field of energy metabolism

Deadline: Until the position is filled
Location: Germany, Düsseldorf  

www.academiceurope.com/ads/research...

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A review of the critical metabolic pathways in health & disease, highlighting advances, limitations & future directions in the development of #EnergyMetabolism based #diagnostics & therapeutics. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Mitochondria, Mind, and Metabolism: The Interoceptive Frontier

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youtube.com/shorts/nYFdm...

Job Alert 🩺

Researcher (Medical doctor) (m/f/div) in the field of energy metabolism

Location: Germany, Düsseldorf, Nordrhein Westfalen

👉 www.academiceurope.com/ads/research...

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Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was supported the Patient-Led Research Collaborative for Long COVID, the AMC and VU foundation, ZonMw Onderzoeksprogramma for ME/CVS, the Solve ME 2022 Ramsay Grant Program, ME Research UK, ME Stars of Tomorrow Scholarship award from the ICanCME Research Network (to B.T.C.), and Stichting Long COVID Nederland. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee of Amsterdam UMC, Medical Association North Rhine (number 2018143) and NASA (Johnson Space Center, Houston, United States) gave ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
doi.org/10.1101/2025...

#ME/CFS #LongCovid #PEM #MitochondrialDysfunction #PostExertionalMalaise #ChronicIllness #EnergyMetabolism
1/8

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was supported the Patient-Led Research Collaborative for Long COVID, the AMC and VU foundation, ZonMw Onderzoeksprogramma for ME/CVS, the Solve ME 2022 Ramsay Grant Program, ME Research UK, ME Stars of Tomorrow Scholarship award from the ICanCME Research Network (to B.T.C.), and Stichting Long COVID Nederland. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee of Amsterdam UMC, Medical Association North Rhine (number 2018143) and NASA (Johnson Space Center, Houston, United States) gave ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
doi.org/10.1101/2025...

#ME/CFS #LongCovid #PEM #MitochondrialDysfunction #PostExertionalMalaise #ChronicIllness #EnergyMetabolism
1/7

Key point: DS-LCLs demonstrate mitochondrial respiration defects, with the most pronounced impairments linked to complex I activity and to a lesser extent complex II of the mitochondrial electron transport chain.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #energymetabolism

Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction - Journal of Neural Transmission Millions of individuals around the world are afflicted with Parkinson’s disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished professor and neurologis...

🔬My latest study published in the Journal of Neural Transmission synthesizes Dr. #Reichmann's groundbreaking contributions to #Parkinson’s disease research, highlighting key insights into #Etiology, #Treatment, and #EnergyMetabolism 🧠✨@springernature.bsky.social
Full paper here: bit.ly/3AKyOAr

Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction - Journal of Neural Transmission Millions of individuals around the world are afflicted with Parkinson’s disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished professor and neurologis...

🔬My latest study published in the Journal of Neural Transmission synthesizes Dr. #Reichmann's groundbreaking contributions to #Parkinson’s disease research, highlighting key insights into #Etiology, #Treatment, and #EnergyMetabolism 🧠✨
SpringerNature
Full paper here: bit.ly/3AKyOAr

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#LowCarbLiving #HighFatDiet #MetabolismBoost #NutritionalScience #TherapeuticFasting #NutritionalMetabolism #EnergyMetabolism #NutritionAndHealth
#CellularHealth #MetabolicBalance

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance Researchers unveil Fas-p53 axis as a key regulator in adipocyte metabolism, linking it to obesity and insulin sensitivity through energy expenditure and inflammation pathways.

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance 🔬🔥🌱 www.news-medical.net/news/2024120... #MetabolicHealth #Obesity #Adipocyte #Biology #EnergyMetabolism #InsulinResistance #FasPathway #p53Regulation #AdiposeTissue

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How carnitine transporters boost reproductive health Research uncovers the critical role of carnitine transporters in maintaining fertility by regulating energy metabolism and protecting reproductive cells from oxidative stress. It suggests new pathways...

How carnitine transporters boost reproductive health 🔬🧬⚡️ www.news-medical.net/news/2024100... #carnitine #fertility #oxidativestress #energymetabolism #infertility #mitochondria #reproductivescience #biochemical

New NIOO publication: #Phosphorus-mediated succession of microbial #nitrogen, #carbon, and #sulfur functions in rice-driven saline-alkali soil remediation. #rice #soilquality #phosphorusavailability #energymetabolism #shotgunmetagenome
https://doi.org/10.1016/j.soilbio.2023.109125