Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome - Nature Metabolism Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.

How does #Circadian dysregulation contribute to #metabolic diseases? With help from Promethion Metabolic Cages, a Nature #Metabolism study has shown how clock dysfunction alters Complex I respiration, impairing #adipocyte oxidative metabolism.

buff.ly/lw6L3R7

#IndirectCalorimetry #Respirometry

New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
www.ahajournals.org/doi/10.1161/...

New review to read! #Metabolic and #appetitive regulation of #adipocyte mass during treatment of #obesity.

👉 Adipose mass is homeostatically maintained within a narrow range despite fluctuations in daily calorie intake and activity levels.

🔗 doi.org/10.1111/joim.70045

@ulsteruni.bsky.social

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💪 New porcine intramuscular #adipocyte #cell model developed! Shows robust #fat accumulation and gene expression, helping us study lipid #metabolism and metabolic syndrome risk 🧬 #Adipogenesis #MetabolicResearch

🔥 New insights in #adipocyte #metabolism! Castro-Rodríguez et al. show how Spot-14 regulates metabolic and thermogenic gene expression in brown and beige adipocytes, offering target for #obesity treatments:

➡️ doi.org/10.1002/1873-3468.70052

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease Abstract. Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone that is synthesized and released from upper intestinal enteroendocr

Glucose-dependent insulinotropic polypeptide in #incretin physiology: role in health and disease. Featured review in #EndocrineReviews #FreeToVew
#GIP #obesity #adipocyte
@endocrinesociety.bsky.social
doi.org/10.1210/endr...

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@shockjournal paper addresses the important issue of sex differences in response to sepsis SEX-DEPENDENT EFFECTS OF ADIPOCYTE STAT3 INHIBITION ON THE... : Shock journals-lww-com.ezproxy.bu.edu/shockjournal... #sepsis #inflammation #adipocyte

Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340

Stem cells isolated from aged mice can be reprogrammed to become adipose (fat) cells! 🧬 In this image, a red dye highlights fat droplets within a cell, while the blue dye marks DNA in the nucleus. A glimpse into cellular transformation!
#lipids #metabolism #adipocyte #aging #stemcells

Melatonin induces white-to-beige adipocyte transdifferentiation through melatonin receptor 1-mediated direct browning and indirect M2 polarization Previous studies have shown that melatonin induces adipocyte browning in vivo. However, the underlying mechanisms of melatonin action at the cellular …

#Melatonin- induced #adipocyte browning appeared to be reflected by the sum of melatonin receptor 1-activated direct browning effects and indirect M2 polarization-mediated effects.
www.sciencedirect.com/science/arti...

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance Researchers unveil Fas-p53 axis as a key regulator in adipocyte metabolism, linking it to obesity and insulin sensitivity through energy expenditure and inflammation pathways.

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance 🔬🔥🌱 www.news-medical.net/news/2024120... #MetabolicHealth #Obesity #Adipocyte #Biology #EnergyMetabolism #InsulinResistance #FasPathway #p53Regulation #AdiposeTissue

Join our joint meeting on Obesity & Adipose Tissue / MASH! Submit abstracts for short talks by 11:59 PM MST, December 4th. Visit hubs.la/Q02Z4Jlq0 or hubs.la/Q02Z4G770.
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#KSObesity25 #KSMASH25 #obesity #adipose #adiposetissue #adipocyte #metabolicdisease #MASH #NASH #NAFLD #MAFLD #fibrosis

No account doesn’t count !#pituirary still First!
However as president of French Endocrine Society I do like all gland even #adipocyte !! 😉

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathw...

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy 🔬💡🔥 www.news-medical.net/news/2024070... #Obesity #Research #Adipocyte #Biology #FatCell #KLF15 #BeigeFat #WhiteAdipocytes #Thermogenesis

Xuan showed that a human-specific #lincRNA is an important regulator of #adipocyte differentiation and de novo lipogenesis in mature adipocytes. 3/n

Congrats to Drs. Xuan Zhang and Muredach Reilly of @Columbia: human-specific lincRNAs regulate #adipocyte #metabolism, with implications for human obesity. It was a great experience being part of the Reilly lincRNA team! #RNA #functionalgenomics...