Does #esketamine have an effect on #remifentanil induced depression of the hypoxic ventilatory response? This study investigates

www.bjanaesthesia.org/article/S0007-0912(25)00...

Treatment-resistant doesn't mean hopeless. Spravato offers an FDA-approved path forward. 💜🩺✨

#MentalHealthCare #Spravato #Esketamine #TreatmentResistantDepression #OPMHS #Hope #MentalWellness

#ketamine #esketamine

How does #esketamine impact life beyond depressive symptoms? A new JCP study examines long-term quality of life and functioning in patients with treatment-resistant #depression treated with esketamine nasal spray.

🎧 jcpjournal.libsyn.com/esketamine-a...
📰 journals.lww.com/psychopharma...

How does #esketamine impact life beyond depressive symptoms? A new JCP study examines long-term quality of life and functioning in patients with treatment-resistant #depression treated with esketamine nasal spray.

🎧 jcpjournal.libsyn.com/esketamine-a...
📰 journals.lww.com/psychopharma...

Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms - Molecular Psychiatry Molecular Psychiatry - Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms

Brain #organoids from healthy & depressed individuals reveal #esketamine alters neural activity & energy metabolism in a time- & dose-dependent way, uncovering a novel link between its antidepressant effects & metabolic reprogramming.

www.nature.com/articles/s41...

Ketamine vs Esketamine: Critical Differences Explained: Palo Alto Mind Body: Concierge Psychiatry If you’ve heard of ketamine and esketamine for depression treatment, you may wonder how they differ. Understanding these two therapies can help you make an in

Ketamine and #esketamine are advanced therapies that may help when traditional depression treatments fall short. While similar, they differ in how they’re used, administered, and covered by insurance—offering new paths to relief for patients.

www.paloaltomindbody.com/blog/ketamin...

Esketamine nasal spray shows rapid antidepressant effects as standalone treatment A new large-scale clinical trial suggests that esketamine nasal spray, used on its own, may offer meaningful relief for adults with treatment-resistant depression. Participants who received esketamine...

Esketamine nasal spray shows rapid antidepressant effects as standalone treatment #Science #HealthandMedicine #MentalHealth #Esketamine #DepressionTreatment #MentalHealthAwareness

Esketamine Rapidly Improves Sleep in Treatment-Resistant Depression Phase 4 data reveal esketamine outperforms standard antidepressants in reducing insomnia and boosting next-day well-being in patients with TRD.

Phase 4 data show esketamine rapidly improves sleep quality in treatment-resistant depression, reducing insomnia and enhancing next-day mental & physical performance. #TRD #Esketamine #SleepHealth

Non-traditional treatments offer ‘remarkable’ results for Omaha metro patients with chronic pain, depression A Fremont mother says a medication, traditionally used as a general anesthetic, has dramatically improved her chronic pain and mental health.

@unmcpsychiatry.bsky.social psychiatrist Stephen Salzbrenner speaks with @wowt6news.bsky.social on why non-traditional treatments, like #Esketamine, offer ‘remarkable’ results for Omaha patients with chronic pain & #depression.
@unmc.bsky.social
@nebraskamed.bsky.social
@drhowardliu.bsky.social

Orange flower

Pink and yellow flowers

Orange lily

Orange oily and crepe Myrtle

#Spravato #Esketamine #TRD #MDD #BipolarDisorder #BPD #OCD #Anxiety #Neuroplasticity
Next week I resume esketamine treatment. It was halted last December due to transportation issues. The nearest clinic was 90 miles away from where I live. My Dr. has opened one 30 miles away.
#Hope

Control Group Outcomes in Psilocybin, SSRI, or Esketamine Trials for Depression This meta-analysis compares depression rating outcomes among patients receiving control treatments in randomized clinical trials of psilocybin vs trials of selective serotonin reuptake inhibitors (SSR...

TTO control en ensayos c/psilocibina tiene menos mejoría en escalas de depresión q TTO control en ensayos c/inh selectivos de recaptación de serotonina o esketamina, eficacia antidepresiva de la psilocibina se ha sobrestimado #psylocibin #esketamine #SSRI jamanetwork.com/journals/jam...

I recently posted I had Generalised Pain Syndrome, but have started IV s-ketamine/esketamine treatment recently. Does anyone have any experience with it? The 1st IV worked for 1.5 weeks, the 2nd 3 weeks & I'm getting them every 2 months. The week it stops working though is absolute hell.

Esketamine Monotherapy in Adults With Treatment-Resistant Depression This multicenter, double-blind randomized clinical trial assesses the efficacy and safety of esketamine monotherapy compared to placebo in reducing depressive symptoms in patients with treatment-resis...

#Esketamine monotherapy for "treatment-resistant depression" shows good effects in this RCT.

Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression: a pooled participant analysis of randomized controlled trials Background Racemic ketamine and its enantiomer, esketamine, have emerged as fast-acting antidepressant options for individuals with treatment-resistant depression (TRD). Yet, despite growing clinical ...

🧠💥 Our new preprint is out!

We pooled 5 RCTs on intranasal esketamine for treatment-resistant depression—and found clear sex-specific patterns in how patients respond.
Read it here: www.medrxiv.org/content/10.1...

#TRD #Esketamine #Neuropsychiatry #OpenScience #MentalHealth

My article describing alternative treatments for treatment resistant depression is on the @NAMIGlendale website. namiglendale.org/alternative-...
#depression #mentalhealth #mentalillness #TMS #esketamine #ECT #psychiatrist #psychologist #treatmentresistantdepression

Can ketamine therapy overcome treatment-resistant depression in Alzheimer's disease and older adults? Preclinical and clinical evidence Treatment-resistant depression (TRD) presents substantial clinical challenges, particularly in patients with Alzheimer’s disease (AD) and older adults…

#Medsky🧪 ##neurosky #pharmasky #publichealth #Ketamine, #esketamine, & #arketamine: mechanisms & impact in treatment-resistant #depression

www.sciencedirect.com/science/arti...

www.sciencedirect.com/journal/biom...

Fundamental and clinical pharmacology for a new psychiatry Click on the article title to read more.

Editorial for Innovation in pharmacology in psychiatry article collection now available!

#SFPT #Wiley #pharmacology #innovation #fundamental #clinical #psychiatry #brain #psychopharmacology #treatment #depression #neuropharmacology #preclinical #esketamine

onlinelibrary.wiley.com/doi/10.1111/...

#Esketamine

In today’s #depressionblog post I explore a metaphor about #depression.
Check it out and help me spread #mentalhealth awareness by sharing.
depressionbentnotbroken.blogspot.com?m=1
#mentalillness #anxiety #psychiatrist #psychologist #psychiatricnursepractitioner #esketamine #therapist

#Ketamine and #Esketamine are both relatively effective for TRD but only Esketamine is #FDA approved for depression and suicidality

Ketamine is administered IV and cheaper but has less evidence for use

Esketamine is administered intranasally and is more expensive

What options are there to treat DtD?

Electroconvulsive Therapy (ECT)
Repetitive transcranial magnetic stimulation (rTMS)
#Ketamine or #Esketamine

New depression treatment using ketamine is getting cheaper for patients A new nasal spray that uses a form of ketamine to treat stubborn depression will be added to the PBS, making treatment cheaper for thousands of Australians.

New depression treatment using ketamine is getting cheaper for patients #ketamine #esketamine #spravato

📊 Key Findings (5-Year Follow-Up):

✅ Esketamine + SNRI:
 ↘️ Lower all-cause mortality
 ↘️ Fewer hospitalizations
 ↘️ Reduced depressive relapse
#doctor #psychiatry #psychiatrist #esketamine #ketamine #depression #mentalhealth

Treatment-resistant depression responds better to esketamine with SNRI than SSRI, study finds Major depressive disorder (MDD) affects approximately 280 million people globally and is one of the leading causes of disability and low quality of life. One in every three people suffering from MDD a...

medicalxpress.com/news/2025-04... #Health #Depression #Esketamine

Want to know how prescription esketamine is making a difference for me? Just ask. #esketamine #ketamine #depression

6 years after FDA approval of #esketamine nasal spray for serious depression an AJP editorial discusses clinical conundrums and unanswered questions. bit.ly/4iu0SJ6

Esketamine Efficacy Questioned 6 Years Following Approval Analysis reveals

A new analysis raises concerns over esketamine’s long-term efficacy for treatment-resistant depression, revealing modest effects and limited evidence for suicidality. Full study details: #MedSky #Esketamine

Metaanalysis raises concern about #esketamine (Spravato):

> Only 1 of 5 trials positive at 4 wk
> Small benefit, similar to antipsychotic aug, declines over time
> Maintenance trials may be biased by WD effects (49% of relapses occurred in 1st 4 wk after stop)

pubmed.ncbi.nlm.nih.gov/39876682