#SmoothMuscleCell expresses #Titin!?😎

Amyloid aggregates of Chicken Gizzard smooth muscle titin prevent adhesion of aortic SMCs & fibroblasts (Making them skinny)

How? Changing substrate topology?

#IJMSMDPI 2021
www.mdpi.com/1422-0067/22...

#SpatialTranscriptomics #GeoMx @nanostringtech #HypertrophicCardiomyopathy

4 Cases+2 Ctrls, 72 ROIs
1800 transcripts

Focal myocyte disarray showing IFN signaling & mito & ECM perturbations

CD99 signaling b/w cardiomyocytes!?🤪

Michael Chin lab #IJMSMDPI 2023
www.mdpi.com/1422-0067/24...

#EndMT #Aortopathy #MarfanSyndrome

A cascade of TGFβ-miR-632-DNAJB6 (#LimbGirdleMuscularDystrophy 1E)-βCat in both #EndothelialCell & #SmoothMuscleCell

miR-632 mimics delivery (lipofectamine) to cultured human aortic fragments

#AortaEd

#IJMSMDPI 2023
www.mdpi.com/1422-0067/24...

Scoring histopathologies of human ascending #AorticDissection (n=52, 32 mortality) vs aneurysm (n=56, 9 mortality)

#CysticMedialDegeneration
Elastin loss
#SmoothMuscleCell loss
Lamellar medial collapse🧐

#AortaEd
Simona Gurzu lab #IJMSMDPI 2023
www.mdpi.com/1422-0067/24...