In this week's episode, we discuss a study from Dr. Stephen Jameson at the University of Minnesota, showing that #IL4 can dial down how strongly memory CD8+ T cells respond to infection without direct antigen stimulation.

📘: https://go.nature.com/3OqIhnk
🎙️: https://bit.ly/40muGA2

Democrat Announces Surprise Electoral Bid As Independent Mayra Macías will run as an independent after Rep. Chuy García schemed to install his chief of staff.

File this under “Throw the bums out, and make the take their lackeys with them!” www.huffpost.com/entry/mayra-macias-chuy-...

#USpol #IL4 #Chicago #ChuyGarcia #PattyGarcia #MayraMacias #NoKings

#IITSEC is just one week away!

Don't miss our joint session on the #Defense Learning Enclave (DLE), our secure learning ecosystem.
📅 Wednesday, December 3
⏰ 11:00 AM EST
📍Booth #894

See you in Orlando!

#IITSEC2025 #DoD #IL4 #LearningTechnology #GovTech #GovCon #LMS

📢 Join us at I/ITSEC 2025 for a joint presentation on PowerTrain’s Defense Learning Enclave (DLE) -- a secure learning ecosystem for #DoD training & readiness.

📅 Wednesday, December 3
⏰ 11:00 AM EST
📍 Booth #894

#IITSEC #IITSEC2025 #LearningTechnology #IL4 #GovTech #GovCon

Chuy Garcia waited till just after the filing deadline to withdraw his candidacy for #IL4 & just by coincidence, his Chief of Staff filed her paperwork to run minutes before the 5pm deadline. No one else is running, so he's effectively handed coronated his successor.

Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.

In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!

🔐 PowerTrain is now officially #DISA #IL4 authorized! Discover how IL4 boosts #CUI protection, accelerates #DoD deployments, and delivers real-time monitoring for mission success: powertrain.com/understandin...

#DISAIL4 #Cybersecurity #Government #Security

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.

ICYMI: earlier this month in #Science #Immunology, bendewals.bsky.social & colleagues reported that #CD22 expression by virtual #MemoryTCells ( #TVM ) inhibits their expansion in response to #IL4 in the context of #helminth infection !

Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E - PubMed Mycoplasma pneumoniae is not only an infectious agent but also an allergen for certain individuals. The P1 protein of MP can induce the production of P1-specific IgE.

pubmed.ncbi.nlm.nih.gov/29555351/

"Tests also demonstrated that the P1 protein stimulated excessive secretion of #IL4 and #IL5 in peripheral blood mononuclear cells from the peripheral blood of healthy donors."

Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E - PubMed Mycoplasma pneumoniae is not only an infectious agent but also an allergen for certain individuals. The P1 protein of MP can induce the production of P1-specific IgE.

Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E #IL4 #IL5 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/29555351/

Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots!

science.org/toc/sciimmunol/10/104

Study identifies how ovarian cancer protects itself, paves way for improved immunotherapy approach Researchers have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study used a…

“ #OvarianCancer has almost been written off as non-responsive to existing #immunotherapy, so it was quite stunning..that by just blocking.. #IL4 & altering the #tumor's microenvironment..cld make these..#tumors more treatable":

IL4 Democratic Candidate for
ILLINOIS 4th Congressional District #IL4 #IL04
JESUS CHUY GARCIA
@ChuyForCongress
http://jesuschuygarcia.com/
Contribute here: https://secure.actblue.com/donate/chuy-garcia-1
#Congress2020 #NoSafeSeats
#PostcardsforAmerica
THREAD

ILLINOIS Democratic Candidates
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18 & Senate
#Congress2020 #NoSafeSeats
#HoldTheHouse #FlipTheSenate
THREAD #PostcardsforAmerica
All 50 States Dem Candidates:
➡️...

ILLINOIS Democratic Candidates
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18
#Congress2020 #NoSafeSeats
THREAD https://x.com/postcards4USA/status/1275246068708581382
FB Post:...

ILLINOIS #IL#VoteByMail
Application www.elections.il.gov/ElectionOperations/Votin...
ILLINOIS Democratic Candidates
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18
#Congress2020...

IL4 Democratic Candidate for
ILLINOIS 4th Congressional District #IL4 #IL04
JESUS CHUY GARCIA
@ChuyForCongress
http://jesuschuygarcia.com/
Contribute here: https://secure.actblue.com/donate/chuy-garcia-1
#Congress2020 #NoSafeSeats
#PostcardsforAmerica
THREAD

ILLINOIS Democratic Candidates
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18 & Senate
#Congress2020 #NoSafeSeats
#HoldTheHouse #FlipTheSenate
THREAD #PostcardsforAmerica
All 50 States Dem Candidates:
➡️...

ILLINOIS Democratic Candidates
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18
#Congress2020 #NoSafeSeats
THREAD https://x.com/postcards4USA/status/1275246068708581382
FB Post:...

Democratic Candidate for
ILLINOIS 4th Congressional District #IL4 #IL04
JESUS CHUY GARCIA
@ChuyForCongress
http://jesuschuygarcia.com/
Contribute here: https://secure.actblue.com/donate/chuy-garcia-1
#Congress2020 #NoSafeSeats
#PostcardsforAmerica
THREAD

Democratic Congressional Candidates Illinois
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL17 #IL18

#Congress2020 #NoSafeSeats
#PostcardsforAmerica
THREAD

Democratic Candidate #IL04 #IL4
Rep Gutierrez retiring
Jesus Garcia @ChuyForCongress
http://jesuschuygarcia.com/
VOTE November 6, 2018
REGISTER Online by October 21, 2018
EARLY VOTING starts September 27, 2018

THREAD

#Illinois #Midterms2018
#BlueWaveIL #BlueWave2018
Unrolled thread from @postcards4USA
All Democratic Candidates. All Districts
Links to their Websites.
#IL1 #IL2 #IL3 #IL4 #IL5 #IL6 #IL7 #IL8 #IL9 #IL10 #IL11 #IL12 #IL13 #IL14 #IL15 #IL16 #IL18...

#CongressRun2018 #IL4
Rep Gutierrez retiring
Sol Flores @standwithsol
Jesus Garcia @ChuyForCongress
(Endorsed by L. Gutierrez & B. Sanders)
Richard Gonzalez @RichG4Congress
Raymond Lopez @RLopez15thWard
Joe Moreno @Alderman_Moreno
Carlos Rosa @CDRosa
@IndivisibleIL @Northside_DFA