📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting new 'immunometabolism' method:

Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting papers 🧪:

I) The immunometabolic topography of cellular organization in TB

II) The human antibacterial factor APOL3 couples lysosomal damage to mtDNA efflux and type I IFN induction.

Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and #immunometabolism in inflammatory macrophages 🧪
www.biorxiv.org/content/10.6...

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy Ageing acts as a double-edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL-6, MMPs), MDSC accumulation and T-cell suppression, fostering ....

#Review in #MedComm_Oncology
#Aging-Derived Alterations in #Genomic, #Immune, and #Metabolic Networks: Implications for Cancer Development and Therapy doi.org/10.1002/mog2...

#cancer #therapy #immunometabolism #TME

Drug that targets immune cells shows potential as new treatment for diabetic heart disease

Thank you @qmulfmd.bsky.social for focus on our #immunometabolism study published earlier this week in @natureportfolio.nature.com Nature Cardiovascular Research 🫀

www.qmul.ac.uk/media/news/2...

Glutathione is critical for NK cell-mediated immunity Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...

Glutathione is critical for NK cell-mediated immunity #immunometabolism www.cell.com/cell-reports...

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Excited to share our latest paper in Nature Cardiovascular Research showing #diabetic #cardiomyopathy is driven by aberrant #immunometabolism Enhancing Treg migratory capacity restores immune balance and improves🫀dysfunction a promising new therapeutic direction in T2D
www.nature.com/articles/s44...

Figure 9: Anti-influenza mechanism of action of cis-aco. DOI: 10.1038/s44321-026-00379-8.

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...

www.nature.com/articles/s41...

Well this is wild! #Immunometabolism #Neutrophils #Mitochondria

Graphical abstract from https://doi.org/10.1016/j.immuni.2026.01.003

Graphical abstract from https://doi.org/10.1016/j.molcel.2026.01.010

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪

biomed.news/bims-imicid/...

Incl.

I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation

II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

#PhD in #immunometabolism on fatty acid oxidation in #macrophage function.
MSCA-DN: unimedizin-mainz.de/unlimited-ms...
For our DC8 position apply in parallel in 2 sites:
1. unimedizin-mainz.de/unlimited-ms...
2. cnic.es/en/convocato...
(DC8: NOT resident in Spain >12m in last 3 years)
#immunosky

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and pathogen escape Pathogens compete for glucose with macrophages, which disrupts host glycolysis, modulates antimicrobial responses and causes macrophage death. We show that, upon glucose starvation caused by major fun...

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and pathogen escape 🧪 #immunometabolism
www.researchsquare.com/article/rs-7...

🔊Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Interesting findings🧪:

I) Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Another pre-print now out from the Everts' Group! For those interested in #immunometabolism #DendriticCells #Type2Immunity. Post-translational O-GlcNAcylation is a process required selectively for Th2 priming by DC.
www.biorxiv.org/content/10.6...

We just published a new paper in Science Advances, where we uncover how #Candida albicans reprograms the metabolism of oral epithelial cells during infection.

As first and corresponding author, I’m excited to share what we found — and why it matters.

#Skytorial #Immunometabolism #MedMycoSky

Our latest collection of commentary and Essays is devoted to #immunometabolism, highlighting how molecular & cellular mechanisms impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism

#cancer #aging #metabolism #inflammation
🧪
@plosbiology.org

Targeting immunometabolism in cancer through pharmacological and lifestyle interventions Immunometabolism is often disrupted in diseases such as cancer, suggesting it could be useful target for therapy. This Essay explores the potential for incorporating both lifestyle changes and drug th...

Finally, on a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to targeting #immunometabolism therapeutically through pharmaceutical and lifestyle interventions, with a focus on #cancer plos.io/4jNASKk

Multi-omics and perturbation screens as discovery tools in immunometabolism Metabolic regulation of immune function is a complex and dynamic process. This Perspective highlights how systems biology approaches, including multi-omics profiling and perturbomics screening, are be...

In their Perspective, Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches in #immunometabolism research as discovery tools for new therapeutic targets.
plos.io/4aR959z

An image of the author on the right, with the text: "The field of immunometabolism not only promises to provide fresh insights into the mechanisms of immune dysfunction, but also offers tools that could be used to restore homeostasis, or at least dial immune responses up or down. I am most excited to see how basic research that elucidates the mechanisms by which metabolism affects immunity will lead to deeper insights into how the immune system shapes physiology."

Senior Editor Lucas Smith discusses his hopes for the field of #immunometabolism in his blog post plos.io/4qd5EOo

An image of the author on the right, with the text: "The field is clearly moving towards trying to address real medical problems using the knowledge we have gained over the past few decades of how immune metabolic pathways govern and guide the immune response. Understanding the interplay between systemic metabolism and the immune response will be crucial if we want to find ways to intervene in conditions with altered metabolism"

First, our Collection Editor Claudio Mauro introduces the theme for the Collection and his vision for the future of #immunometabolism research in his Editorial
plos.io/4qTmEu1

The many facets of immunometabolism This Collection of articles aims to shine a light on the many facets of immunometabolism, highlighting how molecular and cellular mechanisms impact diverse tissue and organismal functions and the exci...

PLOS Biology is proud to present our new collection of comment and opinionated review articles on the many facets of #immunometabolism!

🧪 #immunosky #immunology #metabolism

plos.io/4c5z6Cn

See 🧵⬇️ for more details

🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org!

We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!

Stay tuned!

#obesity #immunometabolism #macrophages #adiposetissue

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com

#academicjobs #tenuretrack #assistantprofessor #immunology #immunometabolism #messerli #vienna #wien #austria #europe #lifesciences #ichforschegerninwien #topforschungwien #topresearchvienna | Andreas... 🔬 Open position: Assistant Professor (Tenure-Track) in Translational Immunology/Immunometabolism 📍Vienna, Austria We are re-advertising a tenure-track Assistant Professorship in Translational Immuno...

Open tenure-track professorship in Translational #Immunology / #Immunometabolism in Vienna, Austria 🔬🥼🧫

For more details about this attractive position at @meduniwien.ac.at see link below. Application deadline is March 31. Thanks for sharing. 🙏

www.linkedin.com/posts/andrea...

Targeting immunometabolism in cancer through pharmacological and lifestyle interventions Immunometabolism is often disrupted in diseases such as cancer, suggesting it could be useful target for therapy. This Essay explores the potential for incorporating both lifestyle changes and drug…

Immunometabolism is often disrupted in #cancer, suggesting it could be useful target for therapy. Heidi Ling &co @hkusbms.bsky.social explore the potential for incorporating #lifestyle changes and drug therapies that target #immunometabolism into treatments for cancer.
🧪 #immunosky

The transition from monocyte to tissue-resident macrophage requires DHPS - Nature In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

The transition from monocyte to tissue-resident macrophage requires DHPS 🧪 #immunometabolism

www.nature.com/articles/s41...
www.nature.com/articles/s41...