Would just like to share that myself and Dr. Erin Mulvihill @uottawa.ca are guest editing a special issue on #incretin hormone action in the #cardiovascular_system for @physiolpharma.bsky.social (cdnsciencepub.com/topic/cjpp-c...)

#Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism & #cardiovascular function, supporting physiological adaptations to nutrient intake www.thelancet.com/journals/lan...
#GLP-1 #GIP

#EndoSky

5.0mg / week - Tirzepatide (MounJaro)
HbA1c 59 -> 39 mmol/mol
13% <weight
in 6 months!

Amazing!

#GLP-01ra #GIP #Incretin #mimetics #peptides #exendin-4 #Gila #Monster #Diabetes #TypeII #Obesity #Inflammation #Mounjaro #Tirzepatide #Type2Diabetes #MetabolicHealth
#InsulinResistance

#Incretin hormones—glucagon-like peptide-1 (#GLP-1) & glucose-dependent insulinotropic peptide (#GIP)—act as a critical link connecting digestion, metabolism & cardiovascular function, supporting physiological adaptations to nutrient intake tinyurl.com/yc5st685
#MedSky #EndoSky #GastroSky #CardioSky

Michael Camilleri writes this #TopicalReview examining #incretin impact on #gastric function in obesity through physiology, and pharmacological, surgical and endoscopic treatments🥼 🔃

🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Constanza Alcaino et al. from @ims-mrl.bsky.social present this #SymposiumReview discussing #incretin hormones and #obesity 💉 🔎

🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Glucagon-Like Peptide 1 (GLP-1) Action on Hypothalamic Feeding Circuits. Read more in #Endocrinology: bit.ly/3WgA4mq #Glucagon-Like-Peptide-1 #GLP1 #Metabolism #Incretin @endocrinesociety.bsky.social

#Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting digestion, metabolism, & cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#GLP-1 #GIP

#MedSky #EndoSky

Featuring our partner #IBL Made in Japan specialised #ELISA and #Antibodies for #neurodegenerative, #kidney, #inflammatory and #metabolism disorders biomarkers #amyloid #angiotensinogen #klotho #incretin #GLP1 #GdIgA1 #nephropathy #glucose

Learn more here: www.stratech.co.uk/our-partners...

Original post on zeroes.ca

@miffyhelen I'm type 2 diabetic AND an inpatient pharmacist. Ever since I started taking #incretin drugs — first #Bydureon (#exenatide), then #Ozempic (#semaglutide), and most recently #Mounjaro (#tirzepatide) — it has transformed my experience of exercise. Before, I never understood how anyone […]

Featuring our partner #IBL specialised #ELISA and #Antibodies for #neurodegenerative, #kidney, #inflammatory and #metabolism disorders biomarkers #amyloid #angiotensinogen #klotho #incretin #GLP1 #GdIgA1 #nephropathy #glucose

Find out more here: www.stratech.co.uk/our-partners...

Incretin-based therapeutics for the treatment of neurodegenerative diseases Neurodegenerative diseases (NDDs) represent a heterogeneous group of disorders characterized by progressive neuronal loss, which results in significant deficits in memory, cognition, motor skills, and sensory functions. As the prevalence of NDDs rises, there is an urgent unmet need for effective therapies. Current drug development approaches primarily target single pathological features of the disease, which could explain the limited efficacy observed in late-stage clinical trials. Originally developed for the treatment of obesity and diabetes, incretin-based therapies, particularly long-acting GLP-1 receptor (GLP-1R) agonists and GLP-1R–gastric inhibitory polypeptide receptor (GIPR) dual agonists, are emerging as promising treatments for NDDs. Despite limited conclusive preclinical evidence, their pleiotropic ability to reduce neuroinflammation, enhance neuronal energy metabolism and promote synaptic plasticity positions them as potential disease-modifying NDD interventions. In anticipation of results from larger clinical trials, continued advances in next-generation incretin mimetics offer the potential for improved brain access and enhanced neuroprotection, paving the way for incretin-based therapies as a future cornerstone in the management of NDDs. This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.

REVIEW | A Vear, MT Heneka and @ClemmensenC (@Metabolcenter, @UMassChan)

This Review summarizes preclinical and clinical evidence highlighting the potential of #incretin-based drugs as treatments of #neurodegenerative diseases.

New data on effect of inflammation on cell function in human #islets, and how #incretin receptor agonists partially restore #glucagon secretion #DiabetesResearch #Endocrinology #MedSky

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease Abstract. Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone that is synthesized and released from upper intestinal enteroendocr

Glucose-dependent insulinotropic polypeptide in #incretin physiology: role in health and disease. Featured review in #EndocrineReviews. #FreeToView #GIP #obesity
@endocrinesociety.bsky.social
doi.org/10.1210/endr...

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease Abstract. Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone that is synthesized and released from upper intestinal enteroendocr

Glucose-dependent insulinotropic polypeptide in #incretin physiology: role in health and disease. Featured review in #EndocrineReviews #FreeToVew
#GIP #obesity #adipocyte
@endocrinesociety.bsky.social
doi.org/10.1210/endr...

#incretin
#glp-2

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

This Research Highlight discusses a paper in Nature, titled Prohormone cleavage prediction uncovers a non #incretin anti #obesity peptide www.nature.com/articles/s41...

A new comprehensive review of GIP action from Professors Timo Müller and Matthias Tschöp et al, from discovery to modern day GIP-enabled medicines. Free to read via Molecular Metabolism #diabetes #obesity #islets #weightloss #incretin @helmholtzhzi.bsky.social www.sciencedirect.com/science/arti...

Then what happened?

Well, you can see that after my aerobics session concluded, my glucose continued to surge and sustain itself until my body's #incretin hormones and #insulin responses finally contained the situation.

Taking a deeper dive into the metabolic response, my body mounted a robust #incretin #GLP-1 #GIP response to this caloric load.

Researchers are uncovering how #incretin hormones like #GLP-1 regulate glucose, appetite, and more. Submit your work on diabetes, obesity, and beyond to the Canadian Journal of Physiology and Pharmacology! Abstracts due: March 17, 2025. ▶️https://ow.ly/69lt50UHHUt

Molecular Integration of #Incretin and Glucocorticoid Action Reverses #Immunometabolic Dysfunction and #Obesity www.cell.com/cell-metabolism/fulltext...