Identification and functional analysis of CLIPA and CLIPE in the innate immune response of #Aedes aegypti #mosquito #innateimmune
onlinelibrary.wiley.com/doi/10.1111/...
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#InnateImmune
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#immunosky
#Neutrophils are the first responders of the #innateimmune system recruited to sites of viral infection. Traditionally known for fighting bacteria, they are now recognized as a "double-edged sword" in viral infections,
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#Medsky🧪 #immunosky @natrevimmunol.nature.com
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes
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Dr. @swculek.bsky.social is a leading expert in innate immune biology. Explore her research and the cutting-edge science behind innate immune cells and their role in health and disease!
▶️ youtu.be/JEz0Ake9-Ro
#AcademicSky #InnateImmune #InnateImmuneSystem
🧪
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This might help to explain some of the complex pathophysiological responses observed during #COVID-infections & #neurocovid related spectrums / #Longcovid sequelas . The #SARSCoV2 break down products & the responses of #innateimmune cells .
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Are you an #RNA enthusiast? Then come to the Australasian 🌏RNA Conference in Sydney 1-3 Sep! I'll be presenting on #innateimmune sensing of RNA in #virus #infection 😎
Travel bursaries are on offer for students and ECRs:
www.a-rnameeting.org.au/travel-bursa...
🧪🧫🔬🧬 (pretend the last emoji is dsRNA)
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The data show that induction of TRIM ( #Trainedimmunity) by certain vaccines confers broad beneficial effects that can protect beyond the target pathogen.
www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
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Confocal images of eye-antennal discs and eye-antennal disc tumors at 96-h after egg deposition. Top row, from left to right: over-expression of LacZ, Cactus, Dorsal, Toll. Bottom row: overexpression of the same genes, but in the presence of Ras-V12 mutation.
Innate immune signaling and #cancer: @basler-lab.bsky.social &co show that the tissue-protective functions of Toll-mediated #InnateImmune signaling can be misused by premalignant cells in #Drosophila to induce overgrowth in early stages of #tumor development @plosbiology.org 🧪 plos.io/4jqpmUh
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Confocal images of eye-antennal discs and eye-antennal disc tumors at 96-h after egg deposition. Top row, from left to right: over-expression of LacZ, Cactus, Dorsal, Toll. Bottom row: overexpression of the same genes, but in the presence of Ras-V12 mutation.
Innate immune signaling and #cancer: @basler-lab.bsky.social &co show that the tissue-protective functions of Toll-mediated #InnateImmune signaling can be misused by premalignant cells in #Drosophila to induce overgrowth in early stages of #tumor development @plosbiology.org 🧪 plos.io/4jqpmUh
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Confocal images of eye-antennal discs and eye-antennal disc tumors at 96-h after egg deposition. Top row, from left to right: over-expression of LacZ, Cactus, Dorsal, Toll. Bottom row: overexpression of the same genes, but in the presence of Ras-V12 mutation.
Innate immune signaling and #cancer: @basler-lab.bsky.social &co show that the tissue-protective functions of Toll-mediated #InnateImmune signaling can be misused by premalignant cells in #Drosophila to induce overgrowth in early stages of #tumor development @plosbiology.org 🧪 plos.io/4jqpmUh
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We are super excited to share our work on #InnateImmune sensing of #AAV 🦠🧬 in the 🧠, just out in @natcomms.nature.com ! 🤩
Huge congratulations to all the team and collaborators 💪🏻
And our funders 💰
@erc.europa.eu #FondazioneTelethon and #FNIH 🙏🏻
www.nature.com/articles/s41...
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Therapeutic strategies targeting STING should carefully balance #innateimmune activation with the protection of T cells from STING-mediated inhibition to maximize treatment efficacy.
www.cell.com/cell-reports... #Immunosky @cellreports.bsky.social
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#Medsky🧪 #immunosky #cardiosky #publichealth COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by
exaggerated and misdirected host immune responses Although pathological #innateimmune activation is well-documented in severe disease,
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Recaps : Overview #InnateImmune Responses & Recombination is a common feature of betacoronavirus evolution and has been detected in #SARSCoV2
@nature.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.frontiersin.org/journals/cel...
www.mdpi.com/2076-2607/12...
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#MedSky🧪 #IDSky #Immunosky #publichealth #NaturalKillercells, A critical component of the viral #innateimmune response, can exhibit dysfunctional phenotypes during acute #COVID19 & these alterations may hinder clearance of #SARSCoV2 infected cells.
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I'm very new to Bluesky, but I'm excited to reconnect with all of my #academictwitter friends again!!
I am working on how #LipidDroplets contribute to our #InnateImmune response following #viruses infection 🦠🔬
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#MedSky🧪 #IDsky #PedSky #ImmunoSky #Mucosalimmunity #Antiviral #innateimmune memory in alveolar #macrophages following #SARSCoV2 infection ameliorates secondary influenza A virus disease
www.sciencedirect.com/science/arti...
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The findings increase our understanding of #innateimmune memory & may enable researchers to exploit the phenomenon in new ways to create therapies that confer widespread protection against multiple viruses.
www.rockefeller.edu/news/36603-c...
www.sciencedirect.com/science/arti...
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#MedSky🧪#IDSky #ImmunoSky #PublicHealth #Innateimmune responses against #mRNAvaccine promote cellular immunity through IFN-β at the injection site . Study found lipid nanoparticle (LNP) or LNP-mRNA challenge in female BALB/c 🐁 .
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The analyses of the nasal swabs of pediatric individuals demonstrate that the innate immune response of the upper airways changes based on the acquisition or clearance of viruses or pathobionts that drive distinct immune programs. Viruses drive anti-viral immune responses, while pathobionts mostly drive TNF and IL-1.
#MedSky🧪#IDSky #PedSky study find an asymptomatic children bear multiple 🦠&/or pathobionts that dynamically regulate the #innateimmune response of the upper airways, explaining protection against severe #COVID19
rupress.org/jem/article-...
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#MedSky🧪 #IDSky #Viralimmunology #Immunology Understanding 🔑 contributor to #COVID19 is #SarsCoV2 ’s utilization of “host shutoff” strategies, optimizing viral replication at the expense of host gene expression and delaying the #Innateimmune response.
www.cell.com/cell-reports...
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