Weekly reads 9/2/25 Systemic programs and structured models across cancer and aging

Weekly reads 9/2/25:
Systemic programs and structured models across cancer and aging

open.substack.com/pub/behindth...

Mechanism + structure > scale alone.

#CancerBiology #SingleCell #Genomics #Aging #Immunology #AIinBiology #LineageTracing

Ep. 282: "Whole-Body Regeneration" Featuring Dr. Mansi Srivastava - The Stem Cell Podcast Dr. Mansi Srivastava is Professor of Organismic and Evolutionary Biology at Harvard University and Curator of Invertebrate Zoology at the Harvard Museum of Comparative Zoology. Her lab uses distantly ...

🥈 2nd place goes to Dr. Mansi Srivastava!

She discussed adult stem cell #LineageTracing and whole-body regeneration in the three-banded panther worm. 🪱

Listen here: bit.ly/4pU9CN2

#InternationalPodcastDay

We have a new episode out!

Dr. Lars Velten from the Centre for Genomic Regulation talks about his research on #LineageTracing and #hematopoiesis: https://bit.ly/4gsvo5X

Early lineage divergence segregates sensory and non-sensory thalamic circuits The thalamus integrates sensory, motor, and associative functions via distinct nuclei, yet the developmental principles driving their specification remain unclear. Here, we generate a spatiotemporal s...

New preprint on bioRxiv! #singlecell #multiomics, #spatialtranscriptomics, #lineagetracing reveal 2 glutamatergic lineages arising from distinct progenitors; Sp9 regulates visual #thalamus fate! By Puche-Aroca et al. @guillelbendito.bsky.social @jplopez-atalaya.bsky.social @neuroalc.bsky.social

Early lineage divergence segregates sensory and non-sensory thalamic circuits The thalamus integrates sensory, motor, and associative functions via distinct nuclei, yet the developmental principles driving their specification remain unclear. Here, we generate a spatiotemporal s...

Excited to share our new preprint on #thalamus development! 🧠 We reveal how sensory and non-sensory circuits are specified in embryogenesis #mutiomics, #spatialtranscriptomics, #lineagetracing. @neuroalc.bsky.social @glb-lab.bsky.social @jplopez-atalaya.bsky.social www.biorxiv.org/content/10.1...

CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages Regeneration can rely on multiple cellular sources, including stem cells, self-duplicating cells, and transdifferentiating cells. A central question in regenerative biology is how these distinct linea...

We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracing

My continued biomedical education

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism

👤"neurons accumulate 15–18 sSNV/cell/year"

Use human somatic mutations (2~4/cell division) for #LineageTracing 🤠

@natrevgenet.nature.com 2025
www.nature.com/articles/s41...

Application deadline extended for Taming the BEAST in Beijing!

Interested in #Bayesian #phylogenetics? 🧬
Join the Taming the BEAST workshop — theory + hands-on tutorials incl. #singleCell, #devBio & #lineageTracing!
📍Beijing, July 14–18, 2025
📅 Apply by April 25
I'll teach on TiDeTree & cell trees
🔗 taming-the-beast.org/news/Deadlin...

3rd Crick Beddington Symposium: Shared Roots and Divergent Paths in the Chick Spinal Cord - the Node During the coffee break on the second day of the 3rd Crick Beddington Symposium, I approached Dr Giulia Boezio, a postdoc in the Briscoe lab at the

Shared Roots and Divergent Paths in the Chick Spinal Cord 🐣

Continuing the poster interviews from the 3rd Crick Beddington Symposium, in this latest post, @alexneaverson.bsky.social chatted with @giulia-boezio.bsky.social about her #LineageTracing work in chick embryos.

#theNodeCorrespondents

DARLIN mouse for in vivo lineage tracing at high efficiency and clonal diversity - Nature Protocols The DARLIN mouse enables the study of the cell lineages of millions of cells and at a high efficiency in vivo, through the incorporation of three barcoding arrays and a Cas9–TdT to improve editing div...

#NewNProt: DARLIN mouse for in vivo #lineagetracing at high efficiency and clonal diversity bit.ly/4hFeoZm

Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation Mouse trophoblast stem (mTS) cells can be derived from the blastocyst or extraembryonic ectoderm as late as embryonic day (E) 6.5 and when cultured in…

Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation
#trophoblaststemcells #lineagetracing

Congratulations McGinnis et al, @drcnatale.bsky.social

www.sciencedirect.com/science/arti...

Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-based fate-mapping provides spatial information, it generally lacks complexity due to limited label div...

Excited to share our preprint: Polytope, an epitope barcoding system, generating up to 512 unique color codes for in vivo lineage tracing. 🌈🧬 This tech enables spatial fate-mapping with unprecedented clonal and spatial resolution! doi.org/10.1101/2024... #SpatialBiology #LineageTracing #Polytope

#barcoding #polytope #imaging #lineagetracing

Happy #FluorescenceFriday! 🔬🫀image shows the zebrafish heart with fli1a:Kaede labeling and a photo-converted outer curvature of the ventricle 🎨#zebrafish #lineageTracing