https://doi.org/10.1093/nar/gkag260 No description available

Discover how 7 DNA repair patterns guide CRISPR outcomes! Dive into genome-wide networks with indel pattern-guided insights. PMID:41891877, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag260 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AAV9 Gene Therapy in Type II GM1 Gangliosidosis Shows Safety Signals but Limited Clinical Improvement in Phase 1-2 Trial.

by Lewis CJ, D'Souza P (...) Tifft CJ et 28 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2510935

4/4 is IgG4-RD Awareness Day. The image promotes an interview with Donna Shipp about their IgG4-RD patient journey. Includes "Rare Care" podcast graphics and the text, "Listen Now.

📆 4/4 is #IgG4RD Awareness Day

Today we recognize all those affected and share Donna Shipp’s story on the Rare Care podcast. A former nurse, she was misdiagnosed with cancer for 6 months before receiving the correct diagnosis.

🎧 Listen: https://bit.ly/4c9t963

#RareDisease #RareCare #MedSky

Urgent crisis in Sudan.

@who.int

#Medsky 🧪

Good News: I finally had a Friday off in the longest time!! So rested!

Bad News: I'm working from 7:30am to 9pm at another clinic today...

Worse News: Your boi is opening his clinic at 3:30am on Monday. So my Sunday day off is essentially shot...

Such is life.

#nursesky #medsky

"The substances were mixed and boiled, and my colleagues detected cell-like moving structures immediately after boiling."

Wilhelm Reich to Roger du Teil
12 December 1936
Beyond Psychology p.81
Edited by Mary Boyd Higgins

#orgone #biophysics #history
#biosky #medsky #psychsky
#dystopian #war #crime

New survey reveals access to primary care growing, but 5.9 million adults in Canada still lack regular doctor Access to primary care in Canada is slowly improving, but nearly 6 million Canadians still lack regular access to a primary care professional, according to a new survey. The OurCare Survey 2025 shows ...

New survey reveals access to primary care growing, but 5.9 million adults in Canada still lack regular doctor

www.cma.ca/about-us/wha...

#medsky

The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome - BMC Medicine Background Inflammation has long-term health impacts across the life course. Breastfeeding substantially reduces inflammation risk, but key pathways, including the extent that this is due to protection against early life infection, are poorly understood. We aimed to investigate the relationships between breastfeeding, inflammation, and infection burden, and to determine the extent to which metabolomic and lipidomic profiles associated with breastfeeding mediate these health outcomes. Methods We utilised data from the Barwon Infant Study (BIS), a longitudinal birth cohort in Victoria, Australia. Infants (n = 889) with available breastfeeding (categorised as yes/no) clinical, metabolomic, and Lipidomic data at 6 and/or 12 months were included (n = 793 at 6 months, n = 734 at 12 months). Inflammation, measured via glycoprotein acetyls (GlycA), at 6 and 12 months and infection burden, including parent-reported and medically attended infections assessed through standardised 3-monthly questionnaires were used as outcomes. Results Any breastfeeding, regardless of supplementary feeding, was associated with lower inflammation, fewer infections, and significant, potentially beneficial changes in metabolomic and lipidomic markers, particularly plasmalogens. There was evidence of bidirectional mediation: metabolomic biomarkers and lipids mediated breastfeeding’s effects on inflammation, while inflammation partly mediated breastfeeding’s impact on certain metabolites and lipids. Conclusions These findings highlight pathways through which breastfeeding reduces inflammation and infection burden, identifying potential targets for optimising infant feeding.

A study in BMC Medicine finds that breastfeeding up to 12 months of age is associated with reduced infection burden and inflammation, as well as differences in metabolomic biomarkers and lipids, mediating much of these beneficial effects.

#MedSky

#Portland Peeps!

“Suck It Up Buttercup,” is having an exclusive screening in Portland on May 31st, at the Tomorrow Theatre.

Special guests: @glaucomflecken.bsky.social & @lglaucomflecken.bsky.social

Stay tuned for 🎟️ coming next week!
#medsky #fpsky #residents #nursesky

The only good thing about the American #healthcare system is that it makes for good television.
#FixUShealthcare #medsky #thepitt

NEJM Editorial Fellow Katerina Lin, MD, explains a clinical trial in which the photovoltaic retina implant microarray (PRIMA) system restored central vision and led to a significant improvement in visual acuity. Read the full PRIMAvera trial results: nej.md/3KP9Jta

#MedSky #Ophthalmology

Analysis of microarray and single-cell RNA-seq identifies gene co-expression, cell–cell communication, and tumor environment associated with metabolite interconversion enzyme in prostate cancer Cancer does not have a universally agreed-upon description, but it is characterized by the unregulated proliferation of cells, which may result in the infiltration of the cell basement or the spread to other organs in the body.

In a Discover Oncology Behind The Paper blog post, the author discusses new perspectives on the molecular properties and pathways of differentially expressed genes in prostate cancer and potential biomarkers that play a crucial role in its genesis.

#MedSky #OncoSky #CanSky

#EHJCVI 🫀Stress imaging guides decision-making in paediatric cardiology. Modality choice should reflect expertise, efficacy, limitations, and safety. This study provides a practical framework across multiple clinical scenarios 🧭 Read more 👉 doi.org/10.1093/ehjc... #Medsky

This is how I picture all the ER doctors looking when we do a procedure. Like, “I can’t believe they let me do this?!”
#EMedksy #Medsky @medksy.social

If you get used to it, then it's time to find another job, referring to losing patients.
#Medsky @medsky.social

A distraught senior citizen phoned her doctor's office.
'Is it true,' she wanted to know, 'that the medication you prescribed has to be taken for the rest of my life?'
'Yes, I'm afraid so,' the doctor told her.
1/2
#Medsky @medsky.social

Efficient Induction of Oligodendrocyte Lineage From Pluripotent Stem Cells via Temporal Modulation of <scp>OLIG2</scp> ( <scp>S147A</scp> ) and <scp>SOX10</scp> There are several protocols for generating oligodendrocytes (OLs) from human pluripotent stem cells, but they are limited by long culture duration, intensive handling and low yield of mature OLs. We d

There are several protocols for generating oligodendrocytes (OLs) from human pluripotent stem cells, but they are limited by long culture duration, intensive handling and low yield of mature OLs. We developed a Tetucible system to contro...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Listen to a short exchange between Ángel and his abuelita, doña Tere, to learn how to say "my feet swelled up" in Spanish! Our patients are our greatest teachers! #medicalspanish #learnmedicalspanish #learnspanish #spanishfornurses #medicalstudent #spanishfordoctors #languagelearning #medsky

PCP vs themselves:
PCP to pt: Pls do not email me at this address: we are asking our patients to communicate their non urgent concerns via the patient portal, aka MyChart
PCP on Epic, to the room: Why do all these patients send me these MyChart messages I don't get paid to manage?
#medsky

You Outta Know - The new geriatric emergency department guidelines.
thesgem.com/2026/04/sgem...
#MedSky @acepnation.bsky.social

Images in Clinical Medicine Minocycline-Induced Hyperpigmentation Panels A and B: Photos of the patient's forearms and shins taken during the physical examination. Panels C and D: Photos taken at the 6-month follow-up.

A 68-year-old woman with rosacea presented with a 6-week history of dark patches on the skin of her arms and legs. Two weeks before the onset of the skin changes, she had started taking minocycline daily. Read the full case details: nej.md/47zLnw9

#MedSky #DermSky #IDSky

Today is the 175th anniversary of the birth of physician Ogino Ginko. After getting gonorrhea from her husband (whom she then divorced), she decided on a medical career to help other women in her situation, becoming the first licensed Western medicine woman doctor in Japan.

#WomenInSTEM #MedSky ⚕️

Our 10th Anniversary - and we keep getting better every year. Join us in Denver, CO August 6-8, 2026 for interactive case-based learning with world-renowned operators. Check out the agenda at cvinnovations.org/cvi2026/ #cme #conference #cardiology #medsky #cardiosky

Top Infectious Disease News Stories Week of March 29 - April 4 | Contagion Live This week, read about omadacycline as an oral treatment option for Mycobacterium abscessus pulmonary disease, combining immunotherapy with antifungals for fungal infections, this year's Peggy Lillis F...

This week, read about omadacycline as an oral treatment option for Mycobacterium abscessus pulmonary disease, combining immunotherapy with antifungals for fungal infections, this year's Peggy Lillis Foundation's C diff meeting, and more. #IDsky #Medsky

If Trump wasn't spending ~$1B a day on war in Iran & pushing a $1.5 trillion military budget, maybe he could actually invest in Americans. #BlueSky #MedSky #LawSky #PoliSky #Iran

The last time human intellectual endeavors were decimated to this extent, western civilization plunged into the Dark Ages…

#MedSky #GreenSky 🧪

Michigan measles outbreak has 8 cases. Cost to keep it contained approaches $100,000. “You’ve got these bigger outbreaks, they’re kind of sending out sparks,” said Dr. William Moss, a professor at the Johns Hopkins Bloomberg School of Public Health.

Michigan measles outbreak has just 8 cases. The cost to keep it from spreading is approaching $100,000. It is one of 17 new measles outbreaks across the U.S. — large and small — since January. My latest ‬… 👇 www.healthbeat.org/2026/04/03/m...
#publichealth #IDsky #medsky #EpiSky

Why an ovary syndrome may get a new name: Men seem to have PCOS, too A quiet effort to change the name of PCOS is nearing completion, driven in part by growing evidence of a male version.

The “This Podcast Will Kill You” team did excellent coverage of this past year. @tpwky.bsky.social #medsky #endocrinology

FKBP5 Regulates the Osteogenesis of Human Adipose-derived Mesenchymal Stem Cells

This research shows that #FKBP5 promotes ASC #OsteogenicDifferentiation, highlighting the potential of FKBP5 targeted therapies for #BoneDisorders & proposing a controllable strategy for ASC based #Transplantation in #BoneDefect repair. #medsky
Read: doi.org/10.1007/s115...

Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial There was no significant difference in all-cause mortality at 10 years between PCI and CABG for patients with unprotected left main coronary artery disease and no additional complex lesions, indicatin...

“Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial.”
Publié ce jour dans @thelancet.com.
#MedSky #CardioSky
www.thelancet.com/journals/lan...