https://doi.org/10.1126/science.aeg1547 No description available

A polymer forms inside animals using a blood protein catalyst, paving the way for innovative therapies. Novel use of bio-catalysis! 🌟 PMID:41926603, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeg1547 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

First Nations Allied Health Graduate Position (Mt Isa)- Closing 20 April 2026 | SARRAH Circle First Nations Graduate. Early Career Professional Opportunity. Build Your Skills in Mount Isa! The dedicated Allied Health team at Mount Isa Hospital are looking for enthusiastic Early Career Profess...

The Allied Health team at Mt Isa Hospital seeking Early Career Professional! (Identified Position)

More info/apply: sarrah.au/oQjeP6

#movetomore #whereareyouheadingtoday #alliedhealthaustralia #alliedhealth #alliedhealthprofessionals #AlliedHealthJobs #medsky #mtisa #identifiedposition #identified

Rural clinics more likely to switch to universal bulk billing - Medical Republic But we’re still missing data on what that has meant for the way rural doctors are practising.

Rural clinics more likely to switch to universal bulk billing, by @hollypayne.bsky.social. But we’re still missing data on what that has meant for the way rural doctors are practising. www.medicalrepublic.com.au/rural-clinic... #medsky

teal background. Healthy mitochondrion on the left in green. Center shows heart and damaged muscle bundles from COVID. Right shows damaged mitochondrion in red and cardiac arrythmia in red.

Dr. Ruth Report 4/12/2026 🗞️

A few important signals this week:

• COVID damages: Heart muscle fibers, mitochondria, epithelial cells & Ear nerves (hearing)
• Long COVID Cost: $135B + $11B/year per country
• 40% report loss smell/taste across 3 nations

👉 Stay informed buff.ly/Ui5Vuzq

#medsky 🛟😷🧪

#medsky take tips

https://www.cell.com/cell/fulltext/S0092-8674(26)00224-2 No description available

Mitochondria regulate glycerolipid synthesis via SLC25A35, which orchestrates the efflux of PEP—crucial for lipogenesis—transforming pyruvate into PEP. PMID:41850288, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-8674... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New preprint: how should we be designing national carrier screening programs for rare autosomal recessive diseases? We did a discrete choice experiment in Singapore to determine how to maximise uptake and minimise budget impacts.
#medsky #reproductivehealth #statsky
www.medrxiv.org/content/10.6...

Lilin Zhao et al. show that combining sonodynamic therapy with #gastherapy (NO, CO, H₂S, O₂, SO₂) creates a synergistic anti-tumor effect by enhancing reactive oxygen species production, relieving tumor hypoxia, and remodeling the tumor microenvironment. doi.org/10.4103/mgr.... #Cancer #MedSky

What is 'immune amnesia?' This long-term side effect of measles is newly relevant. Measles, one of the most contagious viruses in existence, can have devastating impacts, including deadly complications that arise years after the initial infection. Here’s what we know.

What is 'immune amnesia?' This long-term side effect of measles is newly relevant.

www.nationalgeographic.com/premium/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #Measles #Virus #Infection #MeaslesOutbreak #ImmuneAmnesia

COVID-19 is linked to new diabetes cases—but long-term problems could be more severe In addition to driving new cases of diabetes, the virus may be directly damaging the pancreas in ways that could lead to chronic inflammation and even cancer.

COVID-19 is linked to new diabetes cases—but long-term problems could be more severe

www.nationalgeographic.com/science/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #Diabetes #COVID #COVID19 #Coronavirus #Body #Organs #Pancreas #Virus

Advance care planning and caregiver outcomes in advanced cancer: an essential metric of success Despite controversy surrounding Advance Care Planning (ACP) in recent years, high-quality ACP can significantly enhance the care of patients with advanced

“It is centered on preparing patients…to center their values, goals, and worries about their medical care within their present illness experience…”
#oncosky
#medsky
#patientadvocacy

Self-powered in-stent restenosis diagnosis via magnetoelastic stents | Nature Cardiovascular Research Widely used in millions of atherosclerosis treatments, conventional metal stents, although pervasive, only provide mechanical support to narrowed arteries. However, many patients experience in-stent restenosis after implantation. Here we developed smart magnetoelastic stents that preserve mechanical functionality while enabling self-powered hemodynamic monitoring for continuous and timely diagnosis of in-stent restenosis. Using a clinical catheter, the smart stent is deployed in the swine carotid artery for in vivo hemodynamic sensing, enabling effective detection of induced stenosis through artificial intelligence-assisted signal interpretation. In vivo and in vitro studies demonstrate the biosafety of the smart stent through immune profiling, human cytokine analysis and single-cell RNA sequencing. These results underscore the smart stent’s potential for seamless integration into biological systems as a reliable diagnostic tool. This platform technology could potentially revolutionize

Smart magnetoelastic stents in swine carotids enable self-powered monitoring, ensuring timely in-stent restenosis diagnosis post-implantation. PMID:41699202, Nat Cardiovasc Res 2026 https://doi.org/10.1038/s44161-025-00773-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cannabis may make you remember things that never happened Studies show THC can influence multiple stages of memory formation, shaping not just what we remember—but how accurately we remember it.

Cannabis may make you remember things that never happened

www.nationalgeographic.com/health/artic...

#News #WorldNews #Health #PublicHealth #Science #Research #Studies #Medical #MedSky #Cannabis #Pot #Marijuana #THC #Memory #Memories

How COVID-19 harms the heart Many patients are experiencing heart palpitations, chest pain, and shortness of breath even after recovering from COVID-19. But new studies offer reason for hope.

How COVID-19 harms the heart

www.nationalgeographic.com/science/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #Heart #HeartHealth #COVID #COVID19 #Coronavirus #Body #Organs

BOOM.#BlueSky #epstein #MedSky #PoliSky #LawSky

"Visit Seventeen" by Tracie Renee. pulsevoices.org/haiku/visit-... ❤️🏥

Subscribe to Pulse for more stories, artwork, and poems straight to your inbox every week! ✍️

#medicalhumanities #medsky #poems #haiku #poetry #writing #narrativemedicine #stories #healthcare #health

Question for #medsky
Partber had kidney out 2 yrs ago. His voice went odd after the op. Its often weak and a different more husky sound.
Could something have happened re anaesthetic? Is the timing hiding a different issue? He's 65, ex smoker but stopped a couple years before. 1)

AI models can fake visual understanding of images that don't exist It wasn't long ago that news headlines claimed that AI might soon assist radiologists in interpreting X-rays of broken bones and analyzing mammograms. We are still far from the destination, as a new s...

· #MedSky · #Artificialintelligence ·
AI models can fake visual understanding of images that don't exist

Meanwhile, patients fall victim to the functional medicine doctors hawking their marginally useful supplements. It's a $5T industry and growing.

It's going to take $billions to fund the necessary teams and diagnostic equipment to discover or create effective treatments for #LongCOVID.

#medsky

Cover of a mini zine about my infectious diseases life

On Monday, I had to steward MYSELF

On Tuesday, the soundtrack was “mellon collie and the urine culture sadness” On Wednesday, a yeast made me feel nostalgic

On Thursday, the road to Antibiotic resistance hell was paved with good intentions On Friday, the soundtrack was “mellon collie and the infinite prescribing”

A mini zine about My Infectious Diseases Life

Issue #14- golden rules, despite all my rage, talking about a special yeast, good intentions, a rat in a cage

#IDSky #MedSky #zine

Green lollipop I have chosen after getting my flu shot this morning at work 🏥🍭

🌻morning Bluetopia-nothing like a jab early in the morning but yay-I got a lollipop!🍭Get your flu shot people-not only for yourself but everyone around you.Have a great day.We’re short staffed (shocked face🙄) so I’ll talk to you later tonight.Stay safe out there folks 🩵😊🏥 #vaccinate #flushot #medsky

Muscle Weakness Drives Functional Decline in ALL Survivors Muscle weakness, more than neuropathy, strongly predicted impaired mobility and gait in adult survivors of childhood ALL.

Given established links between #Sarcopenia and falls, cardiopulmonary disease, and mortality, early identification is clinically relevant.

Learn more: https://bit.ly/3QsqwVu

#RareDisease #OncSky #MedSky #AcuteLymphoblasticLeukemia

Precancerous niche remodelling dictates nascent tumour persistence | Nature Interactions between mutant cells and their environment have a key role in determining cancer susceptibility1–3. However, understanding of how the precancerous microenvironment contributes to early tumorigenesis remains limited. Here we show that newly emerging tumours at their most incipient stages shape their microenvironment in a critical process that determines their survival. Analysis of nascent squamous tumours in the upper gastrointestinal tract of the mouse reveals that the stress response of early tumour cells instructs the underlying mesenchyme to form a supportive ‘precancerous niche’, which dictates the long-term outcome of epithelial lesions. Stimulated fibroblasts beneath emerging tumours activate a wound-healing response that triggers a marked remodelling of the underlying extracellular matrix, resulting in the formation of a fibronectin-rich stromal scaffold that promotes tumour growth. Functional heterotypic 3D culture assays and in vivo grafting experiments, combining

Newly emerging tumors in mice's upper GI tract reshape their microenvironment to survive, highlighting a critical role in early cancer persistence. PMID:41781610, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10157-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb - Nature Medicine Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.

Monkeypox clade IIb lineage A.2.2 identified in the Republic of the Congo, highlighting urgent need for enhanced surveillance and public health response.

by Koukouikila-Koussounda F, Kwe Yinda C (...) Roch Niama F et 14 al. in Nat Med #MedSky

👉 get more here

📖 read the article:

Microscopic view of bacteria with a vaccine vial and syringe, honoring Robert Austrian for developing a pneumococcal polysaccharide vaccine.

Lasker Laureate Robert Austrian was born #OTD. Austrian, who was at Penn Medicine, developed a polysaccharide vaccine against pneumococcal diseases. Read more: http://ow.ly/tyvV30oehxE

#MedSky #SciSky 🧪

Mesenchymal Stromal Cell Therapy Reduces Relapse Rate and Lesion Burden in NMOSD Intravenous infusion of mesenchymal stromal cells derived from umbilical tissue appears safe, with early evidence of effectiveness in NMOSD.

Results from a phase 1/2a trial showed intravenous human umbilical cord-derived mesenchymal stromal cell (hUC-MSC) therapy may reduce disease activity and neurological impairment in neuromyelitis optica spectrum disorder (#NMOSD).

Learn more: https://bit.ly/3PO79Gt

#RareDisease #MedSky

Protected PCI and Cardiogenic Shock Interventional Octagon 4/14 @ 9 pm ET - Cardiovascular Innovations Please join us at the CVI’s Interventional Octagon competitive case-based learning webinar on 4/14/26 at 9 pm ET. This CME session will focus on Protected PCI and Cardiogenic Shock.  Fellows...

Join us for a Coronary Interventional Octagon - Protected PCI and Cardiogenic Shock. April 14, 9 pm ET. Complimentary registration are at: cvinnovations.org/2026/03/05/c... #cardiology #cme #webinar #medsky #cardiosky

Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment - BMC Cancer Background Elevated serum cholesterol levels are linked to an increased risk of colorectal adenomas and colorectal cancer (CRC), yet the role of serum low-density lipoprotein (LDL) in CRC development remains unclear. This study explores the impact of cholesterol on tumor growth and the potential therapeutic effects of Lactobacillus and Simvastatin. Methods We utilized a cecal tumor xenograft mouse model with Ldlr−/− mice to assess the effects of high cholesterol levels on tumor growth. Additionally, the role of gut microbiota remodeling and cholesterol-lowering strategies was investigated using Lactobacillus supplementation and Simvastatin treatment. Results Ldlr−/− mice on a high-cholesterol diet developed significantly larger tumors (P < 0.05) and exhibited exacerbated malignancy, as indicated by HE and Ki-67 staining. Lactobacillus supplementation reduced tumor growth (P < 0.05), lowered serum cholesterol levels, and altered the gut microbiota composition, increasing the relative abundance of beneficial bacterial taxa. Simvastatin treatment reduced PD-L1 expression in CRC cells by lowering cholesterol levels, which was associated with decreased CRC proliferation, reduced serum LDL levels, and enhanced T cell infiltration in the tumor microenvironment. Conclusion Elevated serum cholesterol promotes CRC progression, while gut microbiota remodeling through Lactobacillus supplementation and cholesterol-lowering interventions, such as Simvastatin, show potential in mitigating tumor growth and enhancing antitumor immune responses. These findings highlight the importance of cholesterol management in CRC treatment strategies.

Elevated serum cholesterol promotes colorectal cancer progression, while gut microbiota remodeling through Lactobacillus supplementation and cholesterol-lowering interventions show potential in mitigating tumor growth, finds a study in BMC Cancer.
bit.ly/3ZJXzGw

#OncoSky #MedSky

#MedSky #PharmSky

Identification of metabolic biomarkers and therapeutic targets in the thymoma-associated myasthenia gravis treated with methylprednisolone - Discover Oncology Objective This study aims to screen and identify metabolic biomarkers and targets for methylprednisolone treatment of thymoma with myasthenia gravis (MG) through metabolomics and network pharmacology analysis, thereby improving guidance for clinical medication and treatment. Methods Serum from 15 patients with thymoma accompanied by severe MG was collected. Changes in serum metabolite levels before and after methylprednisolone treatment were determined using liquid chromatography-mass spectrometry (LC—MS). The raw mass spectrometry fragment information obtained was integrated and interpreted using the metabolomics data analysis software Progenesis QI v2.3. Differential metabolites were screened and identified using univariate and multivariate statistical analysis methods. Subsequently, potential targets of methylprednisolone treatment were identified through network pharmacology, and the mechanism of action of methylprednisolone in treating thymoma with MG was explored in conjunction with metabolomics. Finally, key targets and the upstream synthetic enzymes of critical metabolites identified were validated using Enzyme-Linked Immunosorbent Assay (ELISA). Results A total of 148 differential metabolites were identified in the metabolomics study, among which key metabolites ceramide (Cer) and sphingomyelin (SM) play a significant role in cell immune regulation, inflammatory response, and tumor control. Network pharmacology analysis revealed that tumor necrosis factor (TNF) could serve as a potential target for methylprednisolone treatment of thymoma with MG. ELISA validation results showed that the key target TNF and the upstream synthetic enzymes of the key metabolites SM and Cer were all downregulated after methylprednisolone treatment, with the differences being statistically significant (P < 0.05). Conclusion Our Study reveals that TNF could serve as a potential target for methylprednisolone treatment of Thymoma-associated MG, and Cer and SM could act as potential metabolic biomarkers to assess its treatment efficacy.

A study published in Discover Oncology aims to screen and identify metabolic biomarkers and targets for methylprednisolone treatment of thymoma with myasthenia gravis (MG) through metabolomics and network pharmacology analysis.

#OncoSky #MedSky