Infographic illustrating a European patent application for "Copper-based chemotherapeutics." A central copper atom (Cu) is shown with connecting lines pointing to three panels representing the treatment targets: Breast Cancer, Cervical Cancer, and Pancreatic Cancer. Each panel depicts the respective organ alongside an icon of a fragmenting tumor, indicating the therapeutic effect.

Big milestone for our team! 🧪 We have officially filed a European patent for our latest advances in copper-based chemotherapeutic agents.

Honored to work alongside @conchitagimeno.bsky.social , Raquel P. Herrera and E. Romanos on this. Thanks for the support! 💸

#Metallodrugs #Cancer

New open tools for #metallodrugs !
Sharing work of @edgarlopez2.bsky.social, introducing MetAP DB, the first open-access database of FDA-approved metal-based drugs, and Metal-FP fingerprints.
rdcu.be/eSSNv
#Chemoinformatics #drugdiscovery

The impact of albumin conjugation on the cytotoxic properties of cisplatin, oxaliplatin and auranofin in cancer cells The role of human serum albumin (HSA) in the delivery of anticancer metallodrugs remains unclear and requires further investigation. To this end, bioconjugates of HSA with the metallodrugs cisplatin (...

#OpenAccess article by Tiziano Marzo 𝘦𝘵 𝘢𝘭.
#UniversityofFlorence

𝐓𝐡𝐞 𝐢𝐦𝐩𝐚𝐜𝐭 𝐨𝐟 𝐚𝐥𝐛𝐮𝐦𝐢𝐧 𝐜𝐨𝐧𝐣𝐮𝐠𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝐭𝐡𝐞 𝐜𝐲𝐭𝐨𝐭𝐨𝐱𝐢𝐜 𝐩𝐫𝐨𝐩𝐞𝐫𝐭𝐢𝐞𝐬 𝐨𝐟 𝐜𝐢𝐬𝐩𝐥𝐚𝐭𝐢𝐧, 𝐨𝐱𝐚𝐥𝐢𝐩𝐥𝐚𝐭𝐢𝐧 𝐚𝐧𝐝 𝐚𝐮𝐫𝐚𝐧𝐨𝐟𝐢𝐧 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 𝐜𝐞𝐥𝐥𝐬

#HSA #metallodrugs
#cisplatin #oxaliplatin #auranofin

🔗 doi.org/10.1039/D5QI01487E

We had the pleasure of hosting @akellett.bsky.social (@dublincityuni.bsky.social) at @ciqus.bsky.social for a great lecture on his latest advances in metallodrugs and artificial gene editing.

An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky

We’re excited to host Prof. Andrew Kellett (DCU) @akellett.bsky.social next Friday 24th at @ciqus.bsky.social (11:00 a.m.) for a talk on “Recent Advances in Artificial Gene Editing and DNA-Targeted Metallodrug Design”

#ChemBio #ChemSky #DNA #Metallodrugs

Speciation and structural transformation of a VV–malate complex in the absence and in the presence of a protein
by Eugenio Garribba, Annette Rompel, Antonello Merlino et al.

🔗 doi.org/10.1039/D5QI...
#Vanadium #BioinorganicChemistry #ProteinInteractions #MetalloDrugs #StructuralChemistry

🚀 Reminder: Our preprint “Overcoming Cisplatin Resistance via Deep Learning–Assisted Design of Platinum Complexes” is live on ChemRxiv!
We designed PlatinAI—a platinum complex active against cisplatin-resistant cells via a non-DNA-binding mechanism.
Link in comments 👇
#AI #Oncology #Metallodrugs

👩‍🔬 We trained a deep learning model to create a new platinum complex. It works.
Our latest research, “Overcoming Cisplatin Resistance via Deep Learning–Assisted De Novo Design of Platinum Complexes,” is now live on ChemRxiv! 🔬
Link in comments 👇
#AI #Oncology #Metallodrugs

Cyclodextrin-Based Metal–Organic Framework as an Application Platform for Bioactive Ruthenium(III) Complexes | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Babica, Marek, Jurček, and co-workers @InorgChem #CD #MOF #ruthenium_III #anticancer #metallodrugs #drug_deliver

🧪📣❗ #PhDPosition to develop light-activated drugs for cancer phototherapy. We are seeking candidates with a strong background in #OrganicChemistry #ChemBio and #MedChem to apply for FI-STEP predoctoral fellowships #PDT #Metallodrugs #ScienceJobs

🚀 Exciting news! Our paper “Copper(II) cyclopeptides with high ROS-mediated cytotoxicity” has been accepted in Bioconjugate Chemistry! @pubs.acs.org 🎉

More details soon!

#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky