Today we celebrate π, a constant that reminds us how essential precision, pattern, and curiosity are to scientific discovery. Every calculation, model, and dataset brings us closer to understanding genome integrity and environmental impacts on human health.
#PiDay #EMGS #Genomics #Mutagenesis
Prime-SGE: #saturation #mutagenesis via #primeediting
3825 epegRNAs → 1220 mutations in 7 cancer genes (EGFR, KRAS, BRAF, MET, MEK1, AKT, RIT1)
EGFR inhibitor screen: 17-37 resistance variants/drug. KRAS G12 = pan-resistance. C797S only in covalent inhibitors.
In vivo validated ✓
#CancerResearch
New work in #RESInsectMolecBio
Functions of #melanin synthesis genes, yellow & tan, in wing pigmentation revealed by #CRISPR/#Cas9-mediated #mutagenesis in #Drosophila guttifera
doi.org/10.1111/imb.70024
#ColourPattern
@sassanasgari.bsky.social @gulianusslab.bsky.social @wileyecology.bsky.social
better-experience.blogspot.com/2026/01/from...
#MUTAGENESIS
multi-search-tag-explorer.aepiot.ro/advanced-sea...
#MARESHA
multi-search-tag-explorer.headlines-world.com/advanced-sea...
#ALFIE #DOUGHTY
multi-search-tag-explorer.headlines-world.com/advanced-sea...
aepiot.com
ICEM 2026 is coming to Edinburgh, Scotland!
✨ Theme: Blending new tech with traditional genotoxicity approaches to solve real-world problems.
30 symposia, 10 plenaries, interactive posters & social events!
#ICEM2026 #Mutagenesis #Genomics #ScienceConference
Random #mutagenesis of #influenza #hemagglutinin identifies new sites which modulate its acid-stability and cleavability, etidiohnew.blogspot.com/2025/07/rand...
The 56th Annual Meeting of the #EMGS: "Genomic Health Innovations, Perspectives, and Progress Bloom in the Flower City" is coming up this September 6 - 10, 2025 in Rochester, New York! 🧬🔬
Register Today! emgs-us.org/event/2025EMGS
#DNARepair #Mutagenesis #Toxicology #ScientificConference
💊 Could targeting FLAP's second cytosolic loop aid the development #FLAPInhibitors?
Using site-directed #mutagenesis, Garscha & colleagues reveal mutations in this region influence 5-LOX interaction, inhibitor binding, and #leukotriene formation
➡️ doi.org/10.1002/1873-3468.70066
#inflammation
🚨 NEW in @natgenet.nature.com: MSK's Dr. Sarat Chandarlapaty and colleagues investigates how APOBEC3 #mutagenesis drives therapy resistance in #BreastCancer. Learn more: www.nature.com/articles/s41...
Charlotte Auerbach (1899-1994) was a German-born Scottish geneticist. She studied biology and chemistry at the universities of Würzburg, Freiburg, and Berlin, and initially worked as a secondary-school teacher in Germany. Due to her Jewish heritage, she was dismissed from her teaching position and moved to Edinburgh in 1933. She earned her Ph.D. in genetics from the University of Edinburgh in 1935 and later worked there, making significant contributions to genetics. Auerbach is best known for her research on mutagenesis, showing that chemical substances, such as mustard gas, could cause mutations in living organisms. Although her findings were not published for several years due to the political climate during World War II, they eventually led to the development of chemical mutagenesis and had a lasting impact on genetic research and cancer studies. Auerbach's contributions earned her honors, including election to the Royal Society of Edinburgh and several honorary degrees.
#40 from my Women in STEM series: Charlotte Auerbach
#WomeninSTEM #genetics #academicsky #skystorians #mutagenesis #womenshistory
And here the question: are they both active? which one is the responsible for the GalT activity? We combined #mutagenesis with #biophysics and #moleculardynamics to show that only the GT2 domain exhibits catalytic activity, facilitated by an unusual Glu-Asp-Asp motif critical for Mn²⁺ binding.
IT IS CRITICAL THAT PEOPLE GET ACQUAINTED WITH THIS AND STOP THIS IMMEDIATELY
#GMO #geneticmanipulation #geneticengineering #mutagenesis
food.ec.europa.eu/plants/genet...
#GeneEditing is key to speed up #plantbreeding for climate-resilient, high-yielding crops. Now it has been shown that targeted #mutagenesis can also be implemented in grain #amaranth, which is a resilient C4 dicot orphan crop with excellent #nutrition composition: doi.org/10.1101/2025... #CRISPR
#CRISPR can improve disease resistance in #wheat by giving access to a broader range of solutions beyond random #mutagenesis or intraspecific variation. #Geneediting can unlock new ways to improve crops & speed up #plantbreeding for resistance to crop diseases: www.frontiersin.org/journals/gen...
First up on day 2 of @euromedchem.bsky.social #EFMCISCB25 is Ben Davis from @ox.ac.uk talking about awesome #chemistry to edit #proteins eg. chemical #mutagenesis, such as Cys>Dha>Xxx transitions #chembiol #chemsky
Freisleben used radiation-induced #mutagenesis to create the barley 𝘮𝘭𝘰 mutant, which showed full resistance to this pest. A massive agricultural breakthrough!
See also Classic #2, to read about how Emmy Stein has developed this technique in 1921:
bsky.app/profile/soms...
And here are a bunch of tags. Haha.
#Drosophila #HomologyDirectedRepair #Mutagenesis #CRISPR #bioRxiv #ScienceMethods #ChromosomalInversions #GeneTagging #Genetics #Neuroscience #Evolution #Development
I put "GMO" in quotes because currently nobody in Europe knows what a GMO plant is and what not. The definition changes depending on who you ask and who is asking. A long story that I'll have to document one day.
#GMO #mutagenesis #TransposableElements #breeding
#Organic farming is dishonest when it comes to genetic engineering as it also uses #GMO varieties—namely those developed by #mutagenesis. Costs of #GMOs are driven by approval hurdles, not patents: www-topagrar-com.translate.goog/acker/news/p... #biotech #patents (1/2)
Excerpt from Reinholz' paper: "Mullers 1) grundlegende Entdeckung der mutations auslösenden Wirkung kurzwelliger Strahlen (1927) hat die Hoffnung aufsteigen dassen, Evolutions-vorgänge künstlich und willkürlich herbeizuführen. Die zahlreichen bisher durchgeführten Versuche waren indes nicht yon dem erwarteten Erfolg gekrönt. Mit tier Einbeziehung immer weiterer Objekte in den Kreis der Betrachtungen zeigte sich vielmehr um so ausgeprägter eine starke Herabsetzung der Lebenseignung der Mutanten (Tollenaar, Gager und Blakeslee, Goodspeed und Olsom, Stein, Stadler, Timoféeff-Ressovsky, Delaunays, Langendorff, Stubbe, u. a.). Ihre Bedeutung für die Artbildung wäre erloschen, wollte man sie als ,,erbliche Erkrankungen" auffassen.
A quick addendum in reference to #PlantScienceClassics #2: Laibach’s student Erna Reinholz established x-ray #mutagenesis of A. thaliana, curiously referencing Muller’s 1927 Science paper, as well as a 1929 paper by Emmy Stein – but also ignoring her pioneering 1921 work.
📜 A fully sequenced collection of homozygous EMS mutants for forward and reverse genetic screens in Arabidopsis thaliana
🧑🔬 Sébastien Carrère, Laurent D. Noël, et al.
📔 @biorxiv-plants.bsky.social
🔗 doi.org/10.1101/2023...
#️⃣ (Feeds) #PlantScience #Genomics #Mutagenesis #PlantResource
A collage of images from Stein's 1935 paper "Zur Genetik, Histologie und Zytologie einer neuen, durch Radiumbestrahlung erzeugten krebsigen Entartung von Antirrhinum majus", showing irradiation induced damage to cells underlying the shoot meristem, the vasculature of a stem, and even images of chromosomes with abnormal shapes.
Over the next 25 years, she continued publishing on the effects of irradiation in ever-increasing detail, incl. on cancerous tissue, & chromosomal damage. Her work was instrumental in establishing & advancing radiation-induced #mutagenesis, #genetics, & #Antirrhinum as early plant model.
