Interesting story about the role of #oncofetal RNA-binding proteins in #immune #evasion in #ovarian #cancer.

ONLINE FIRST ALERT!

Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

aacrjournals.org/bloodcancerd...

@aacrjournals.bsky.social

#childhoodcancer
#epigenetics
#precisiononcology

Out in @naturegenet.bsky.social: Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. Amazing work by @sleemmz.bsky.social
👏 Check it out here: rdcu.be/d9kD0 👈 #colorectalcancer #CRC #organoids #therapyresistance #oncofetal #reprogamming Congrats!!

1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity

Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵

Out now @naturegenet.bsky.social:

**Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer**

www.nature.com/articles/s41...

Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer.

#science
#epigenetics
#OncoSky

#Cancer #ChildhoodCancer #Leukemia #Neuroblastoma #DevelopmentalOrigin #Oncofetal #Reprogramming #Plasticity #Biomarkers #DrugTargets #DevelopmentalBiology #CancerBiology #Epigenetics

Do you think fetal transcription signatures are the consequence of a maturation block of a prenatal cell-of-origin in #childhoodcancer ?

This might not always be true!

Evidence for #oncofetal #reprogramming can be found in our new preprint @dblipka.bsky.social

www.biorxiv.org/content/10.1...