Welsh firm Antiverse raises funds for AI antibody platform Cardiff's Antiverse has raised $9.3m to develop its AI-based design platform for antibodies against hard-to-reach targets like GPCRs and ion channels.

#Antiverse #AI #AIantibodyplatform #biotech #drugdiscoveryprogrammes #antibodybasedtherapeutics #antibodies #drugtargets #Gproteincoupledreceptors #GPCR #ionchannels #NxeraPharma #GPCRs #cellularcommunication #transmembraneprotein #Tcellreceptor #TCR #antiPD1antibodies #drugdiscovery
zurl.co/cAKcg

💊 Phosphatidylinositol 4-kinases are central regulators of cellular signaling and membrane trafficking, yet are frequently hijacked by pathogens. This review discusses their dual roles and evaluates their potential as #DrugTargets for #InfectiousDiseases. 🦠 doi.org/10.1002/1873...

Dysregulated FGF signaling can fuel tumor growth and therapy resistance—but how it rewires cancer metabolism is still unclear. This review shows how understanding these pathways and their role in #CancerMetabolism could reveal new #DrugTargets.

➡️ doi.org/10.1002/1873-3468.70199

Inositol pyrophosphates are powerful messengers that guide early development and shape health later in life. This review highlights how IP6K and PPIP5K enzymes control #CellSignals and why they’re promising #DrugTargets for future therapies.

➡️ doi.org/10.1002/1873-3468.70192

An interesting talk by Ben Cravatt at Scripps | #chemsky #DrugDiscovery #DrugTargets

Genetex is extending their #antibodies product line against human #GPCR. GPCRs play a crucial role in the normal and pathological regulation of many physiological systems which makes them essential #biomarkers and #drugtargets for a multitude of diseases, inc #cancer
🔗https://tinyurl.com/bdaphf48

A comprehensive #proteomic analysis of GSRCC specimens identified novel #proteomic subtypes, complex #TumorHeterogenity, potential prognostic #biomarkers & #DrugTargets, and highlighted #Neratinib as a promising therapeutic. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

@metabolon.bsky.social , @estbiobank.bsky.social, @mdpiopenaccess.bsky.social, #EstonianBiobank, #Genetics, #Metabolomics, #Sequencing, #RareGeneticVariants, #DrugTargets #LossOfFunction, #HumanKnockOut. 🧬🧬🧬 2/13

Largest ever genome-wide association study uncovers new drug targets and potential therapies for osteoarthritis – BioNews Central A combined study of genetic data from nearly 2 million people—including about 500,000 with osteoarthritis and 1.5 million controls—found 962 genetic markers linked to the condition, 513 of which were new. ...

A combined study of #GeneticData from nearly 2 million people—including about 500,000 with #osteoarthritis and 1.5 million controls—found 962 #GeneticMarkers linked to the condition, 513 of which were new.
#GenomeWideAssociationStudy #GWAS #DrugTargets #TherapeuticTargets

New key genes in Parkinson’s disease identified using CRISPR technology – BioNews Central Researchers employed CRISPR interference technology to systematically examine every gene in the human genome, discovering new genes linked to Parkinson's disease that could lead to novel therapeutic targets. ...

Researchers employed #CRISPRInterference technology to systematically examine every gene in the #HumanGenome, discovering new #genes linked to #ParkinsonsDisease that could lead to novel #TherapeuticTargets.
#Parkinsons #DrugTargets

👁️ The Role of Th17/Treg Axis in Retinal Pathology Associated with Diabetes and Treatment Options

🔗 pubmed.ncbi.nlm.nih.gov/40136531/

🌐 #INPST #DrugTargets

I'm a fan of @opentargets.org. It has some nice prioritisation tools. I'm curious if homology to bacterial targets is ever used as a factor in prioritisation? If a cmpd was likely to be sequestered in the gut, would you lower the priority, or simply consider it an optimisation problem. #drugtargets

#Cancer #ChildhoodCancer #Leukemia #Neuroblastoma #DevelopmentalOrigin #Oncofetal #Reprogramming #Plasticity #Biomarkers #DrugTargets #DevelopmentalBiology #CancerBiology #Epigenetics

Wow!!! IDO1 inhibition rescues LTP in both Tau and AB models of Alzheimers Disease

Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms!

#neurodegenerativeDeisease #science #drugTargets