Neuroimaging findings in neurodegenerative disorders are often complex, as imaging findings in patients with mild signs and symptoms are frequently subtle and ambiguous. In many cases, by the time imaging findings become obvious, patients have already manifested clinically, and the diagnosis is already established or at least highly suspected. The radiation-free PCASL-MRI approach helps, based on the perfusion profile, to achieve an early and accurate diagnosis prior to gross morphological alterations when standardized with PET in simultaneous PET-MRI acquisitions. PCASL and PET changes preceded structural atrophy patterns and could aid in establishing early clinical diagnosis. The combination of PET and PCASL boosted the sensitivity of structural MRI and PET by synergistically diagnosing disease conditions. The synergistic effect of PCASL and FDOPA boosted the sensitivity and specificity in classifying disorders with dopaminergic deficit into IPD/APD phenotypes without the need for additional FDG PET or D2-receptor imaging. The authors highlight the role of simultaneous PCASL PET-MRI in the workup of complex neurodegenerative conditions with FDG in centers that do not have a cyclotron facility for producing non-FDG tracers. In clear-cut clinical neurodegenerative disorders, where structural changes are equivocal, an additional PCASL sequence can help in early diagnosis without the need for PET studies.

On #WorldParkinsonsDay, I'd like to highlight “ASL as a Potential Biomarker in Imaging of #Neurodegenerative Disorders” by Prof. Sandhya Mangalore, et al. (Nat. Inst. of Mental Health and Neurosciences, India).

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#NeuroSky #MRI #PETMRI

Register now for a free ASFNR-ASNR webinar on July 9 at 1:00 pm ET (note DiFFeReNT time)!
“Seeing The Invisible: PET/MRI Advancements in Brain Tumor Evaluation”
Register: ow.ly/kWgK50WgMyI
#PetMri
#beyondBOLD #NeuroRadiology #MedEd

Puri T, Blake GM, Frost ML, Siddique M, Moore AE, Marsden PK, Cook GJ, Fogelman I, Curran KM. Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using 18F-fluoride PET-CT. Nucl Med Commun. 2012 Jun;33(6):597-606. doi: 10.1097/MNM.0b013e3283512adb. PMID: 22441132. Puri, T. (2011). Bone metabolism measured with six quantification methods using 18F-PET, World Molecular Imaging Congress. In World Molecular Imaging Congress, 7-10 Sept 2011, San Diego, California, USA. https://lnkd.in/e7XvCEaR

What are the 6 ways to quantify [18F]NaF PET-CT imaging? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #HealthyBones #BoneResearch #ImagingInnovation #EarlyDetection #StrongBones

Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018 Feb;8(1):47-59. doi: 10.21037/qims.2018.01.02. PMID: 29541623; PMCID: PMC5835654.

What are precision errors, and what do they mean in [18F]NaF PET imaging? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #boneimaging
doi: 10.21037/qims.2018.01.02

Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018 Feb;8(1):47-59. doi: 10.21037/qims.2018.01.02. PMID: 29541623; PMCID: PMC5835654.

When using [18F]NaF PET, which is the most effective parameter to assess treatment response? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #ImagingInnovation doi: 10.21037/qims.2018.01.02

Zhang Y, Chen Y, Huang Z, Zhang L, Wan Q, Lei L. Comparison of 18F-NaF PET/CT and 18F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma. Contrast Media Mol Imaging. 2018 Sep 5;2018:8271313. doi: 10.1155/2018/8271313. PMID: 30254551; PMCID: PMC6145050.

[18F]NaF vs [18F]FDG PET-CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer doi: 10.1155/2018/8271313

Lin, F.I., Rao, J.E., Mittra, E.S. et al. Prospective comparison of combined 18F-FDG and 18F-NaF PET/CT vs. 18F-FDG PET/CT imaging for detection of malignancy. Eur J Nucl Med Mol Imaging 39, 262–270 (2012).

[18F]FDG+[18F]NaF PET-CT vs [18F]FDG PET-CT imaging for detection of malignancy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #CancerResearch #BoneRemodeling doi: 10.1007/s00259-011-1971-1

Iagaru A, Mittra E, Yaghoubi SS, Dick DW, Quon A, Goris ML, Gambhir SS. Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study. J Nucl Med. 2009 Apr;50(4):501-5. doi: 10.2967/jnumed.108.058339. Epub 2009 Mar 16. PMID: 19289439.

Cocktail [18F]NaF and [18F]FDG PET-CT Scan for Evaluation of Malignancy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.2967/jnumed.108.058339

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[18F]NaF PET Ki is considered a marker of bone formation, then, why is it used to study cancer-related bone metastases? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging www.linkedin.com/feed/update/...

Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab (1994) 79(6):1693–700. doi: 10.1210/jcem.79.6.7989477

When to perform [18F]NaF PET scan for estimating bone metabolism post-treatment? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1210/jcem.79.6.7989477

Happy New Year to All #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #HealthyBones #Osteoarthritis #BoneResearch #ImagingInnovation #cancer #prostatecancer #breastcancer #metastasis

Detecting Bone Spread in Bladder Cancer - [18F]NaF PET-CT vs 99mTc-MDP SPECT-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #bonecancer
doi: 10.1097/RLU.0b013e31828da5cc

Cook, G.J., Parker, C., Chua, S. et al. 18F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin). EJNMMI Res 1, 4 (2011). https://lnkd.in/es9x4ckh

[18F]NaF PET as a Way to Track Treatment Response in Bone Metastases from Prostate Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging
#cancer #prostat #prostatecancer DOI: 10.1186/2191-219X-1-4

Jadvar H, Desai B, Conti PS. Sodium 18F-fluoride PET/CT of bone, joint, and other disorders. Semin Nucl Med. 2015 Jan;45(1):58-65. doi: 10.1053/j.semnuclmed.2014.07.008.

[18F]NaF vs [18F]FDG PET-CT in Detecting Occult Metastatic Disease in Prostate Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #prostatecancer doi: 10.1053/j.semnuclmed.2014.07.008

Hu H, Hu X, Liang Z, Yang W, Li S, Li D, Cai J. Diagnostic performance of 18F‑FDG PET/CT vs. 18F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncol Lett. 2024 Sep 12;28(5):546. doi: 10.3892/ol.2024.14679. PMID: 39319212; PMCID: PMC11420642.

[18F]FDG vs [18F]NaF PET-CT in breast cancer with bone metastases #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #ImagingInnovation
doi: 10.3892/ol.2024.14679

Aaltonen L, Koivuviita N, Seppänen M, Tong X, Kröger H, Löyttyniemi E, Metsärinne K. Correlation between 18F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients. Bone. 2020 May;134:115267. doi: 10.1016/j.bone.2020.115267. Epub 2020 Feb 11. PMID: 32058018.

Correlation between [18F]NaF PET and bone histomorphometry in renal osteodystrophy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1016/j.bone.2020.115267

Araz M, Aras G, Küçük ÖN. The role of 18F-NaF PET/CT in metastatic bone disease. J Bone Oncol. 2015 Sep 16;4(3):92-7. doi: 10.1016/j.jbo.2015.08.002. PMID: 26587375; PMCID: PMC4648995.

Role of [18F]NaF PET-CT in Diagnosing Bone Metastases #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #metastases #bone doi: 10.1016/j.jbo.2015.08.002

Petrén-Mallmin, M., Andréasson, I., Ljunggren, Ö. et al. Skeletal metastases from breast cancer: uptake of 18F-fluoride measured with positron emission tomography in correlation with CT. Skeletal Radiol 27, 72–76 (1998). https://doi.org/10.1007/s002560050340

[18F]NaF PET for Detecting Bone Metastases in Breast Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #cancer #breastcancer doi.org/10.1007/s002...

Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, et al. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Br J Radiol 2014;87:20130444.

[18F]NaF PET in differentiated thyroid carcinoma
#18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling doi: 10.1259/bjr.20130444

Special Issue Information (Submission Deadline: 20 May 2025) #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling #EarlyDetection www.mdpi.com/journal/jcm/...

Chan SC, Wang HM, Ng SH, Hsu CL, Lin YJ, Lin CY, Liao CT, Yen TC. Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. J Nucl Med. 2012 Nov;53(11):1730-5. doi: 10.2967/jnumed.112.104893. Epub 2012 Sep 7. PMID: 22961077.

[18F]NaF PET for Detecting Bone Spread in Head & Neck Cancer #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #ImagingInnovation doi: 10.2967/jnumed.112.104893

Usmani S, Marafi F, Esmail A, Ahmed N. Initial experience with 18F-sodium fluoride (NaF) PET-CT: a viable functional biomarker in symptomatic Os acromiale. Br J Radiol. 2018 Apr;91(1084):20170741. doi: 10.1259/bjr.20170741. Epub 2018 Jan 12. PMID: 29293370; PMCID: PMC5966011.

Shoulder Pain Mystery Solved with [18F]NaF PET #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1259/bjr.20170741

Kuo J, Foster C, Shelton D. Particle disease on fluoride-18 (NaF) PET/CT imaging. J Radiol Case Rep. 2011;5(5):24-30. doi: 10.3941/jrcr.v5i5.697. Epub 2011 May 1. PMID: 22470793; PMCID: PMC3303443.

Particle Disease on [18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #Osteoarthritis #BoneResearch #ImagingInnovation #BoneWellness #BoneImaging #BoneRemodeling doi: 10.3941/jrcr.v5i5.697

Dweck MR, Jenkins WS, Vesey AT, Pringle MA, Chin CW, Malley TS, Cowie WJ, Tsampasian V, Richardson H, Fletcher A, Wallace WA, Pessotto R, van Beek EJ, Boon NA, Rudd JH, Newby DE. 18F-sodium fluoride uptake is a marker of active calcification and disease progression in patients with aortic stenosis. Circ Cardiovasc Imaging. 2014 Mar;7(2):371-8. doi: 10.1161/CIRCIMAGING.113.001508. Epub 2014 Feb 7. PMID: 24508669.

[18F]NaF PET and Heart Valve Disease #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #StrongBones #BoneWellness #CartilageCare #EarlyDetection #ArthritisAwareness doi: 10.1161/CIRCIMAGING.113.001508

Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ. 18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement. Clin Nucl Med. 2017 Jul;42(7):537-539. doi: 10.1097/RLU.0000000000001647. PMID: 28319505; PMCID: PMC5453819.

[18F]NaF PET for Melorheostosis #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection
doi: 10.1097/RLU.0000000000001647

Omarjee, L.; Mention, P.-J.; Janin, A.; Kauffenstein, G.; Le Pabic, E.; Meilhac, O.; Blanchard, S.; Navasiolava, N.; Leftheriotis, G.; Couturier, O.; et al. Assessment of Inflammation and Calcification in Pseudoxanthoma Elasticum Arteries and Skin with 18F-FluroDeoxyGlucose and 18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography Imaging: The GOCAPXE Trial. J. Clin. Med. 2020, 9, 3448.

Detecting inflammation/Calcification in Pseudoxanthoma Elasticum using [18F]FDG/[18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi.org/10.3390/jcm9...

Figure 1. The 18F-NaF neck skin uptake. Maximal intensity projections (MIP) and axial images with intense neck skin uptake in a pseudoxanthoma elasticum (PXE) patient with Phenodex index of 6 (left panel). Keywords: pseudoxanthoma elasticum; Phenodex; disease activity; 18F-NaF PET/CT Gutierrez-Cardo, A.; Lillo, E.; Murcia-Casas, B.; Carrillo-Linares, J.L.; García-Argüello, F.; Sánchez-Sánchez, P.; Rodriguez-Morata, A.; Baquero Aranda, I.; Sánchez-Chaparro, M.Á.; García-Fernández, M.; et al. Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum. J. Clin. Med. 2020, 9, 1393.

[18F]NaF PET for Monitoring Calcium Buildup in Pseudoxanthoma elasticum #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #EarlyDetection #ArthritisAwareness lnkd.in/ezcPvmjV

Atzeni IM, Hogervorst EM, Stel AJ, de Leeuw K, Bijl M, Bos R, Westra J, van Goor H, Bolling MC, Slart R, Mulder DJ. [18F]Sodium Fluoride PET has the potential to identify active formation of calcinosis cutis in limited cutaneous systemic sclerosis. Semin Arthritis Rheum. 2022 Aug;55:152027. doi: 10.1016/j.semarthrit.2022.152027. Epub 2022 May 18. PMID: 35687922.

Detecting Calcifications in Systemic Sclerosis (SSc) using [18F]NaF PET. #imaging #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging DOI: 10.1016/j.semarthrit.2022.152027

[18F]NaF PET Imaging for Plaque Calcification #cardiology #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi: 10.1161/CIRCIMAGING.118.008712

Key Words: PET, CT, molecular imaging, peripheral arterial disease. Eisert SN, Chou TH, Bobbey AJ, Go MR, Stacy MR. Noninvasive Detection of Active Microcalcification in an Occlusive Peripheral Vascular Aneurysm Using 18F-NaF PET/CT Imaging. Clin Nucl Med. 2020 Dec;45(12):1029-1031. doi: 10.1097/RLU.0000000000003344.

Spotting Hidden Blood Vessel Changes with [18F]NaF PET/CT #PET #CT #molecularimaging #arterialdisease #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #petct #petmri #precisionmedicine #precisionimaging #microcalcification doi: 10.1097/RLU.0000000000003344