Solving the gene classification problem with a novel Gene Space approach Genomic organization and its comparative analysis throughout all major kingdoms of life are extensively studied across multiple scales, ranging from individual gene-level analyses to system-wide inves...

Solving the gene classification problem with a novel Gene Space approach
doi.org/10.1101/2025...

KIPEs3: Automatic annotation of biosynthesis pathways
doi.org/10.1101/2022...

#Bioinformatics #ProteinFunction

@biodataganache.bsky.social is now up. VaLPAS: Leveraging variation in experimental multi-omics data to elucidate protein function. #ismbeccb2025 #ProteinFunction #bioinformatics

Now up: Semi-Supervised Data-Integrated Feature Importance Enhances Performance and Interpretability of Biological Classification Tasks
Jun Kim &
@rbaltman.bsky.social

#ProteinFunction #ismbeccb25 #bioinformatics

Careers — Align to Innovate

4/4
What’s coming:
→ More protein functions
→ Sharper ML strategies
→ Public data access portal
→ And yes—we’re hiring.
🔗 alignbio.org/careers
#openbiology #machinelearning #proteinfunction #bioengineering

A longitudinal analysis of function annotations of the human proteome reveals consistently high biases Abstract. The resources required to study gene function are limited, especially when considering the number of genes in the human genome and the complexity

Thanks to An Phan, Parnal Joshi from my lab, and to Claus Kadelka 🧵 (4/4)

📄 academic.oup.com/database/art...
#Bioinformatics #ProteinFunction

Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

Expanding the toolbox for #ProteinTagging: #Posttranslational #ProteinEditing in living #MammalianCells allows classic cell biology experiments while retaining #ProteinFunction www.science.org/doi/10.1126/... @BurslemLab #TranslationalScience

#Cytochrome #NitrogenCycle #Spectroscopy #Catalysis #Heme #Haem #NitrousOxide #Hydroxylamine #Greenhouse #ProteinResearch #ScientificReview #Biochemistry #MolecularBiology #ProteinStructure #LifeSciences #ResearchInnovation #ScienceCommunity #AcademicPublishing #ProteinFunction

DEADLINE EXTENDED: The new deadline for submission of manuscripts for this special issue is 31 January 2025.

📝 Call for Papers: Special Issue on "AlphaFold in Protein Structure and Function Prediction".

🔗https://www.csbj.org/call_AlphaFold

#AlphaFold #ProteinStructure #ProteinFunction

Study identifies cellular and molecular roots of individual brain connectivity differences Researchers link microscopic protein structures and cellular interactions to individual differences in brain connectivity, offering new insights into brain function and variability.

Study identifies cellular and molecular roots of individual brain connectivity differences 🧠🔬🧬 www.news-medical.net/news/2024110... #Brain #Neuroscience #HumanBrain #MolecularResearch #ProteinFunction #Agin #BrainMapping #Neuroimaging

CAFA-evaluator: A Python Tool for Benchmarking Ontological Classification Methods
#ontologies #bioinformatics #python #ProteinFunction

arxiv.org/abs/2310.06881