Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development - Molecular Biomed... Traditional antiviral strategies primarily rely on vaccines and virus protein-targeting drugs, which adopt a virus-targeting approach. However, the rapid mutation of viruses often leads to vaccine fai...

#Research
#Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development doi.org/10.1186/s435...

#PostTranslational #modification #Virus #AP1G1 #Clathrin

Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

Expanding the toolbox for #ProteinTagging: #Posttranslational #ProteinEditing in living #MammalianCells allows classic cell biology experiments while retaining #ProteinFunction www.science.org/doi/10.1126/... @BurslemLab #TranslationalScience

P-stalk ribosomes identified as key regulators of immune evasion in cancer Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencin...

P-stalk ribosomes identified as key regulators of immune evasion in cancer 🔬✨💥 www.news-medical.net/news/2024102... #Cancer #Immunotherapy #Ribosomes #Tumor #Cytokines #PostTranslational #CellBiology #ImmuneResponse #CancerBiology