Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

Expanding the toolbox for #ProteinTagging: #Posttranslational #ProteinEditing in living #MammalianCells allows classic cell biology experiments while retaining #ProteinFunction www.science.org/doi/10.1126/... @BurslemLab #TranslationalScience