In Conclusion
#SARSCoV1 & #SARSCoV2 both manipulate host epigenetic mechanisms including DNA methylation, histone modifications, RNA methylation & noncoding RNA regulation to facilitate infection, modulate immune responses & promote viral replication.
DNA methylation is involved in down-regulating antigen-presenting molecules in MERS-CoV but not in #SARSCoV1
The epigenetic landscape of #SARSCoV2 is still being elucidated, but it appears to involve a broader range of host epigenetic regulators & pathways compared to #SARSCoV1
While both viruses exploit host epigenetic machinery, there are differences in the specific mechanisms used. eg., MERS-CoV uses H3K27 methylation to control interferon-stimulated genes, whereas this is not observed in #SARSCoV1
This synthesis demonstrates that #SARSCoV1 and #SARSCoV2 utilize a complex array of epigenetic interference strategies, affecting host gene expression, immune responses, and disease outcomes through direct and indirect mechanisms
- Shared and distinct mechanisms: Both #SARSCoV1 & #SARSCoV2 utilize epigenetic interference to modulate host responses. #For SARSCoV1, epigenetic changes can interfere with antigen presentation and interferon-response gene activation.
For #SARSCoV2, similar strategies are employed,
🧨Comparative Findings
Conservation of Mechanisms: Small RNAs and certain non-structural proteins (e.g., nsp1) are conserved between #SARSCoV1 & #SARSCoV2, suggesting shared strategies for host epigenetic interference.
Both #SARSCoV1 & #SARSCoV2 produce small viral RNAs
(svRNAs) that can act as triplex-forming oligonucleotides (TFOs) to target host gene enhancers, facilitating host adaptation and virulence.
-Histone Citrullination and NETosis: Severe COVID is associated with increased levels of
Functional genomic screens identified genes involved in chromatin regulation and histone modification as important for CoV infection. The SWI/SNF chromatin remodeling complex & HMGB1, which regulates ACE2 expression, were highlighted as key host factors for viral entry in both #SARSCoV1 & #SARSCoV2
#Medsky🧪 #IDsky #immunosky #publichealth Overview of Epigenetic Interference Mechanisms in #SARSCoV1 & #SARSCoV2 .Functional genomic analysis of #SARSCoV1 & #SARSCoV2 has identified several mechanisms
#Tcellmemory has been observed to persist for at least 6–12 mths, some studies report functional exhaustion of CD4+ T cells after 1 year
- Comparison with Other Coronaviruses: Studies on #SARSCoV1 & T cell memory can last for several years as long lasting #Tcell responses are suggested for #SARSCoV2
Remember all those sick soldiers after the Gulf War, apparently all mentally ill?
Once again, something has become psychological, which are post-infectious symptoms. Scientists suspect #MERS, the Middle East sister of #SARScov1 and #SARSCov2. 30-40% became ill
pubmed.ncbi.nlm.nih.gov/40117126/
Ihr wisst noch diese ganzen kranken Soldaten nach dem Golfkrieg, anscheinend alle psychisch krank?
Mal wieder wurde etwas psychisch, was postinfektiöse Symptome sind. Wissenschaftler vermuten #MERS, der middle East Bruder von #SARScov1 und #SARSCov2. 30-40% Kranke
pubmed.ncbi.nlm.nih.gov/40117126/
I didn't depend at all on the CDC for info for #SARSCoV1
Eric Feigl-Ding
@drericding.bsky.social was my go-to for COVID19
We should be able to access most of these resources.
www.globalcitizen.org/en/content/c...
#DemVoice1 #DemsUnited
Gerade in Toronto ist das nach den Erfahrungen mit #SARSCoV1 überhaupt nicht zu verstehen.
#MedSky🧪 #IDSky #ImmunoSky #Publichealth In this study shed new light on the behavior of proteins that play 🔑 role in the interaction bw #SARSCoV1 & #SARSCoV2 & human cells. Their findings may help explain why #SARSCoV2 responsible for #COVID19, more infectious & rapidly spread than #SARSCoV1 .
#Blockfutter
Beschäftige mich seit über 4 Jahren mit dem Thema der Covid. Gründungsmitglied bei den ersten Long Covid Gruppen in Spanien. Lese regelmäßig Studien auf Lancet und in Nature zu dem Thema. Hab' Leute in Kanada kontaktiert, um mich zu #SARSCoV1 zu informieren. Klar, hab natürlich 0 Ahnung
Es gibt seit vielen Jahren Forschung zu den Long COVID Folgen von #SarsCOV1 insofern, gab und gibt es bereits viele relevante Erkenntnisse, die angesichts der Liebe zur Durchseuchungspolitik einfach nicht beachtet worden sind.
#LongCovid existiert
#MECFS existiert
#Covid hat Spätfolgen, auch wenn das geleugnet wird. Siehe #SARSCov1
#WestNilVirus
karin-kelle-herfurth.de/long-covid-i...
A new #YouTube #video title is vying for the crown as worst ever: "Was #SARS the original #COVID?"
It's asking if Sudden Acute Respiratory Syndrome, #Corona Virus Disease 1 (SARS-CoV-1, COVID 1) was the original of SARS-CoV-2...
😑
#SuddenAcuteRespiratorySyndrome #CoronaVirus #SARSCoV1 #SARSCoV2
#TheseEyes
#TheGuessWho
I saw then at #SARS #SARSCONCERT2003
YUP, #COVIDTHEFIRST #COVIDORIGINAL #COVIDOG
#ACDC #ROLLINGSTONES
etc.
YUP #SARSCOV1 #SARCOV2 BEEN WITH US, NOT NEW PEOPLE. that is why they were working on #VACCINES #20YEARS laughing at conspiracies
music.amazon.ca/albums/B001H...
#Pasteur 2004 #FrédéricTangy 67 ans a breveté un vaccin efficace contre #SarsCoV1. Persuadé que le nouveau coronavirus ressemble au prédécesseur il obtient rapidement le feu vert et les subventions pour se pencher sur un vaccin contre le #SarsCoV2 mais...
ladepeche.fr/amp/2021/02/25…
#Pasteur 2004 #FrédéricTangy 67 ans a breveté un vaccin efficace contre #SarsCoV1. Persuadé que le nouveau coronavirus ressemble au prédécesseur il obtient rapidement le feu vert et les subventions pour se pencher sur un vaccin contre le #SarsCoV2 mais...
ladepeche.fr/amp/2021/02/25…
