Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system | PNAS In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC) death promoting early neurodegeneration and clinical disab...

#microbiome #CIDP #neurology #health #SCFAs #geriatrics #health #immunology #autoimmune

The short-chain fatty acid (SCFA)
propionate,
produced by gut microbiota,
exerts neuroprotective and neuroregenerative effects
in the peripheral nervous system.
.
www.pnas.org/doi/abs/10.1...

Short-chain fatty acids: Gatekeepers of gut and metabolic health Mechanistic insights into metabolism, immunity, and disease prevention.

Dietary fiber—though indigestible—fuels gut bacteria to produce SCFAs, powerful messengers that influence glucose, weight, immunity, and gut integrity. The fiber–microbiota–SCFA axis is a key to preventing chronic disease and optimizing health.

medium.com/@AutophagyFa...

#SCFAs #GutMicrobiome

Circulating short chain fatty acids are associated with depression severity and predict remission from major depressive disorder Short-chain fatty acids (SCFAs) have been shown to improve depression-like behavior in animal models. However, their predictive value for depression o…

#publichealth #geriatrics #health #microbiome #mentalhealth #MDD #primaryhealthcare #biomarkers #SCFAs #neurology #dietetics #biosensors #gastroenterology

Higher plasma butyrate (produced by gut microbiota)
predicts remission from depression within 6 months.
.
www.sciencedirect.com/science/arti...

📚MedChemExpress Digest| Targeting 𝗚𝘂𝘁 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝘁𝗮 for 𝗖𝗮𝗻𝗰𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆
Microbiota-targeted strategies can enhance immunotherapy: antimicrobials, metabolites, probiotics, engineered bacteria, oncolytic viruses, phages, and #FMT.
Microbial metabolites retain high bioactivity: #SCFAs #Inosine #TMAO

#primaryhealthcare #microbiome #algorithms #health #apps #telemedicine #gerontology #geriatrics #ecotoxicology #pathology #agedcare #healthy #aging #ehealth #digitalhealth #datascience #publichealth #healthinformatics #SCFAs #Alzheimers #dementia #Parkinsons #AI #healthcare #SDGs #healthliteracy

Increases in Circulating and Fecal Butyrate are Associated With Reduced Blood Pressure and Hypertension: Results From the SPIRIT Trial | Journal of the American Heart Association

#cardiology #preventivecardiology #geriatrics #health #microbiome #hypertension #bioinformatics #NCDs #primaryhealthcare #gastroenterology #CVD #SCFAs

Linear association between
increases in circulating butyrate
and reduced blood pressure and hypertension
.
www.ahajournals.org/doi/full/10....

Short-chain fatty acids in mood and schizophrenia spectrum disorders: Evidence in the field and translational perspectives The etiology of mood and schizophrenia spectrum disorders remains largely unknown. In recent years, several studies have focused on the role of the mi…

The present article provides a narrative review of studies examining the physiological roles of #SCFAs, along with animal model and human studies addressing the involvement of SCFAs in mood and #schizophrenia spectrum disorders, formulates future directions and provides translational perspectives.

https://www.sciencedirect.com/science/article/pii/S000629522500053X

This review critically summarizes current knowledge regarding effects of #SCFAs in fine-tuning of pathogenesis of type 2 #diabetes mellitus & insulin resistance, with an emphasis on complex relationships among diet, #microbiota -derived metabolites, #T2DM inflammation, glucose #metabolism.

🚀 Implications for Microbiome-Based Interventions
* Dietary strategies should be tailored to functional states rather than taxonomy.
* #Low-fiber diets may be more effective for Archetype 1-dominant IBD patients with high #SCFAs.
9/n

Gut-derived sugars: A potential game-changer for weight management and diabetes Gut bacteria-produced exopolysaccharides (EPS) help regulate metabolism by modulating gut microbiota, promoting SCFA production, and improving glucose homeostasis. S. salivarius, a key EPS producer, s...

Gut-derived sugars: A potential game-changer for weight management and diabetes 🔬🦠🔥 www.news-medical.net/news/2025013... #Gut #Health #Microbiome #Metabolism #Obesity #Diabetes #Probiotics #SCFAs #BloodSugar @naturecomms.bsky.social

How gut microbiota impacts childhood obesity Gut microbiota plays a critical role in childhood obesity by influencing energy metabolism, inflammation, and appetite regulation, with emerging therapeutic strategies like probiotics, dietary interve...

How gut microbiota impacts childhood obesity 🌱🧬🍎 www.news-medical.net/news/2025012... #ChildhoodObesity #GutHealth #MicrobiotaResearch #ObesityTreatment #Probiotics #GutBrainAxis #SCFAs #HealthyLiving #ObesityScience #MicrobialTherapy

Gut microbiome and brain evolution: New insights into energy allocation Gut microbiota from primates with larger brains promotes glucose production and energy allocation for brain function, shedding light on metabolic strategies in evolution.

Gut microbiome and brain evolution: New insights into energy allocation 🧠🧬🌍 www.news-medical.net/news/2024120... #Microbiome #BrainEnergy #Metabolism #PrimateRs #Evolution #GutHealth #SCFAs #MicrobialScience #BrainFunction #EnergyBalance

Gut transit time and pH shape microbiome individuality and dietary responses Scientists reveal gut transit time and pH as key drivers of microbiome and metabolic individuality, paving the way for personalized dietary strategies.

Gut transit time and pH shape microbiome individuality and dietary responses 🧬🩺🥗 www.news-medical.net/news/2024120... #GutHealth #Microbiome #Nutrition #GutResearch #Metabolism #SCFAs #SmartPill #GutMicrobiota #Health @naturemicrobiol.bsky.social

Colon-delivered short-chain fatty acids attenuate the cor... Short-chain fatty acids (SCFAs) are products of microbial...

Interesting to see #GutMicrobiota-related 'Colon-delivered short-chain fatty acids attenuate the #cortisol response to psychosocial #stress in healthy men: a randomized, placebo-controlled trial' #SCFAs derive from #DietaryFiber ahttps://www.nature.com/articles/s41386-020-0732-x