Fundamental & Clinical Pharmacology: Vol 40, No 2 Click on the title to browse this issue

March issue now available!
#fundamental #clinical #pharmacology #statin #pharmacovigilance #addictovigilance #cannabis #ambroxol #dupilumab #buscopan #inflammation #cytokine #SGLT2i #heart #drug #repositioning #antinociceptive #SFPT @wileyhealth.bsky.social
onlinelibrary.wiley.com/toc/14728206...

This multicenter, randomized, double-blind trial demonstrates that Tongxinluo capsule + standard #Statin therapy increases minimum fibrous cap thickness and reduces lipid arc in #AcuteCoronarySyndrome patients.

#STTT #OpenAccess: doi.org/10.1038/s413...

Scientists finally explain statin muscle pain Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side…

" #Researchers have discovered why #statins can cause #MusclePain: the drugs force open a key #muscle channel, flooding #cells with calcium. The finding could help scientists design next-generation statins.": buff.ly/erbgV0D

via sciencedaily
#cholesterol #medication #statin #medicine

The more I outlive dad (he lived to 53, I am 59) the more medications become necessary. Just was prescribed a #statin for hereditary high cholesterol. In dad's defense, this comes from both sides of the family. But he was the one with the blocked heart valve. Good times, eh, fellow #GenXers ? 😀🤔😅😏

Could a Zero Calcium – CAC Score – Mean You Don’t Need a Statin? MDs use coronary artery calcification, CAC scores, to determine heart disease risk. Does the CAC predict heart attacks? Do statins raise CAC?

Could a Zero Calcium – CAC Score – Mean You Don’t Need a Statin? www.peoplespharmacy.com/articles/how... via @peoplespharmacy

#calcium #statin #heart #heartdisease #CAC #health

Lipid Goal Achievement With Statins Among Statin-Naïve Indian Patients Undergoing Percutaneous Coronary Intervention The effectiveness of current statin therapy in achieving lipid targets in Indian patients remains uncertain. This observational study aimed to evaluate lipid goal attainment at 1 and 6 months with ato...

📖New Insights on #Statin Therapy in South Indian #PCI Patients. 💡 Results: Only ~41–42% of statin-naïve patients hit their lipid goals, highlighting the need for stronger post-PCI #lipid-lowering strategies.

▶️ www.jscai.org/article/S277...

#CardioSky

Cholesterol Treatment Trialists' Collaboration calls for revision of ‘misleading’ statin labels Most potential undesirable effects listed in statin product labels are not specifically caused by statin treatment.

#MedNews - Most potential undesirable effects listed in #statin product labels are not specifically caused by statin treatment.

Full story 👉 buff.ly/Hoqh9hl

#CardioSky #Cholesterol

Atorvastatin‐Associated Liver Injury: Outcome After Statin Rechallenge Background Statin-induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin-induced liver injury becau...

Now available in Open access:
Atorvastatin-Associated Liver Injury: Outcome After Statin Rechallenge
#fundamental #clinical #pharmacology #liver #statin #drug #treatment #pharmacovigilance @sfpt-fr.org @wileyhealth.bsky.social @jlcracowski.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

Patient death sparks concern over pharmacists’ ‘limited’ access to patient records A coroner raised concerns over Welsh pharmacists’ ‘limited’ access to patient records after a patient died from contraindicated medication.

Patient death sparks concern over pharmacists’ ‘limited’ access to patient records

buff.ly/irPWhEc

#patient #death #patientdeath #Wales #pharmacy #statin #medicines

Deprescribing.org - Optimizing Medication Use Deprescribing.org - reducing medications safely to meet life’s changes. Online resources for clinicians and patients to help with deprescribing.

Great to see deprescribing.org mentioned throughout the article as a leading organization in the deprescribing movement. Find our resources to guide appropriate deprescribing (including our new #statin deprescribing resources) here:
deprescribing.org/resources/de...

Most listed statin side-effects are not caused by the drug, study finds Health information around statins should be revised as most side-effects listed in the product labels are not caused by the drugs, a major new study finds.

Most listed statin side-effects are not caused by the drug, study finds

buff.ly/QBmUTDw

#statin #sideeffects #medicines #statins #pharmacy #UKpharmacy

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials.

www.thelancet.com/journals/lan...

@thelancet.com
#CardioSky #Statin

Scientists finally explain statin muscle pain Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side effects....

Remember when your doctor told you that your muscle pains weren't caused by your #Statin? They don't really do that? It was just a coincidence and you needed to exercise more because you were getting older? Yeah, about that...

www.sciencedaily.com/releases/202...

My body’s reaction to rosuvastatin is so severe that I may be allergic to it. #statin #sideeffects #allergicreaction

The FDA considers that a problem that can cause temporary or reversible health problems.

If you take this medication, please check with your pharmacist or healthcare provider.

#DrugRecall #Statin #HealthSafety #FDA

www.cardiovascularbusiness.com/topics/clini...

Leqvio Monotherapy Approved for Adults With Hypercholesterolemia The FDA has approved a labeling update for Leqvio (inclisiran) allowing for first-line use in the treatment of hypercholesterolemia.

Update removes the requirement for #Leqvio to be used as an adjunct to #statin therapy.

Read More: https://bit.ly/47c9alL

New article to read! 🚨💊 Statins linked to ↓ risk of #IBD:

👉In a Danish cohort of >650K adults eligible for #statin use for primary CV prevention- statin use was associated with a 16% lower risk of developing #IBD.

🔗 doi.org/10.1111/joim.70034

Observational studies, which have shown positive associations with #statin use & outcomes, are prone to confounding factors, such as the healthy user effect, which RCTs are designed to avoid.
It is also possible that different variants of #SARSCoV2 & variations in statin dosage affect outcomes.

Cardiology Drugs Barry Newman speaks with Dr. Fahmi Farah, Cardiologist and Director of Bently Heart in Ft. Worth, Texas.  They talk about cardiology procedures including stents and  bypass, and drugs that treat cholesterol and high blood pressure.

📣 New Podcast! "Cardiology Drugs" on @Spreaker #atorvastatin #bloodpressure #cardiologist #cardiology #cholesterol #collegeradio #drugstore #health #healthy #heart #hearthealth #longisland #pharmacist #pharmacy #statin #whpc

Fundamental & Clinical Pharmacology: Vol 39, No 5 Click on the title to browse this issue

FCP October issue now available!

#SFPT #pharmacology #fundamental #clinical #drug #rat #statin #cholesterol #heart #repurposing #pharmacokinetic #antibiotic #cancer #anxiety #brain #therapeutic #neural #cisplatin #genitourinary #integrin #cell

onlinelibrary.wiley.com/toc/14728206...

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies This review highlights the integration of drug repurposing and nanotechnology-driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidi...

Now available in Open Access:
Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies

#pharmacology #SFPT #Wiley #clinical #fundamental #statin #antifungal #drug #candidiasis #nanotechnology #treatment

onlinelibrary.wiley.com/doi/10.1111/...

Statins Tied to Longer Survival in Advanced Prostate Cancer A new study links statin use to better overall survival in men with advanced prostate cancer who received apalutamide, but statin use also came with greater cardiac risks.

Statins Tied to Longer Survival in Advanced Prostate Cancer @medscape.com
A new study links #statin use to better overall survival in men with advanced #prostate cancer who received apalutamide, but statin use also came with greater cardiac risks.

#Statin use in pregnancy seems to be safe for growing fetus. In women at high CV risk, benefits of statin use likely outweigh potential risks

#CardioObstetrics #CardioSky
academic.oup.com/eurheartj/ad...
@mdharringtonc.bsky.social @abraguo.bsky.social @anastasiasmihaili.bsky.social

He's 50 Years Old; His Cardiovascular Age is 57 A heart risk calculator developed by the American Heart Association can tell you how your heart age compares to your chronological age.

You're 50 Years Old; Your Cardiovascular Age is 57
A heart risk calculator developed by the American Heart Association can tell you how your heart age compares to your chronological age. bit.ly/4m735MH @jama.com @nufeinbergmed.bsky.social #heartattack #statin #hearthealth #aging #Cardio #heartrisk

Genes related to #cholesterol processes had increased expression in colonies formed after HMA exposure, regardless of the colony's methylation level. Targeting these processes with #statin co-treatment increased the efficacy of HMAs.

Frontiers | Statin use during intensive care unit stay is associated with improved clinical outcomes in critically ill patients with sepsis: a cohort study BackgroundDespite early goal-directed therapy, sepsis mortality remains high. Statins exhibit pleiotropic effects, including anti-inflammatory and antimicrob...

Estatinas se asocian con una menor mortalidad en pacientes críticos con sepsis #statin #ICU #sepsis www.frontiersin.org/journals/imm...

Impact of Statin Nonacceptance on Cardiovascular Outcomes in Patients With Diabetes | Journal of the American Heart Association

Pacientes con diabetes que retrasan la terapia con estatinas tienen mayor riesgo CV, mediado por LDL más altas. #statin #CV #diabetes www.ahajournals.org/doi/10.1161/...

a person is holding a small violin in their hand with the caption poor thing . ALT: a person is holding a small violin in their hand with the caption poor thing .

#rage-a-holics with a #statin & #booze problem & not much else to fiddle with…

Statins: No evidence of a clinically relevant pharmacological interaction between atorvastatin/simvastatin and direct oral anticoagulants was found in this cohort and case-crossover study doi.org/10.3399/BJGP... #PrimaryCare #Statin #GeneralPractice #Research #Statin

Duration and type of statin use and long-term risk of type 2 diabetes among men and women with hypercholesterolaemia: findings from three prospective cohorts - Diabetologia Aims/hypothesis Findings from RCTs and observational studies indicate a positive association between statin use and risk of type 2 diabetes. Mendelian randomisation studies provide evidence to support...

Data from three large cohorts @harvardepi.bsky.social showed that statin use was associated with higher #T2D risk, especially with longer use and varied by statin type. A healthy lifestyle may help reduce this risk during statin treatment #Diabetes #Statin link.springer.com/article/10.1...