IRF7-driven microglial #inflammation damages #neurons in #TemporalLobeEpilepsy by suppressing RORB–STIM1 signaling, highlighting IRF7 as a central regulator and promising #neuroprotective therapeutic target for drug-resistant TLE.
#OpenAccess: doi.org/10.1016/j.ge...
The degree and frequency of language decline reported in research literature are influenced by the protocols used to assess language functions.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #confrontationnaming #languageoutcomes #reliablechange #temporallobeepilepsy #verbalfluency
This scoping review systematically discusses these etiologies and their interactions, guided by a bibliometric analysis using VOSviewer software.
doi.org/10.1111/epi....
#Epilepsy #ILAE #epilepsia #causality #mesialtemporalsclerosis #systematicreview #temporallobeepilepsy
Semantic Functioning in Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis
Alpitsis, R., Eyres, J. et al.
Paper
Details
#TemporalLobeEpilepsy #SemanticFunctioning #MetaAnalysis
nNOS deficiency in adult-born DGCs increases dendritic length, branch complexity, and spine density.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #dentategranulecells #neuronalnitricoxidesynthase #pilocarpine #temporallobeepilepsy
Our findings demonstrated a significant impact of tPC resection on outcomes at both 2-year and 5-year follow-ups in mesial TLE.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #antiseizuremedicationwithdrawal #hippocampalsclerosis #seizurefreedom #temporallobeepilepsy #temporalpiriformcortex
Key point: Hippocampectomy does not significantly impact seizure freedom in TE-related epilepsy (RR = 0.66, p = 0.329).
doi.org/10.1002/epi4...
#epilepsy #epilepsiaopen #ilae #epilepsysurgery #hippocampectomy #seizurefreedom #temporalencephaloceles #temporallobeepilepsy
Key point: MALDI-MSI and LC–MS-based label-free quantitative proteomics revealed regional lipidomic and proteomic changes in PET+ versus PET− TLE samples.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #lipidomics #MALDIMSI #metabolism #proteomics #temporallobeepilepsy
Key point: Gray matter atrophy of temporal lobe epilepsy (TLE) is constrained primarily by structural connectivity rather than by functional connectivity.
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #connectome #diseaseepicenter #networkspreading #temporallobeepilepsy
Key point: Ictal activity reveals frequency-dependent connectivity between dorsal and ventral amygdala regions.
doi.org/10.1111/epi....
#epilepsy #ILAE #amygdala #coherence #connectivity #epilepsysurgery #temporallobeepilepsy #timefrequencyanalysis
Key point: Reduced spatial EEG sampling with a wearable device can consistently detect epilepsy cases in patients with clinical suspicion of TLE.
doi.org/10.1002/epi4...
#Epilepsy #ILAE #EEG #neurotechnology #temporallobeepilepsy #wearabledevices
Key point: Optogenetic stimulation of dentate gyrus granule cells leads to strong synaptic activation of mossy cells.
doi.org/10.1111/epi....
#epilepsy #ILAE #channelrhodopsin2 #excitotoxicity #patchclamp #retigabine #temporallobeepilepsy
Website myrondyal.com
Instagram @myrondyal
We had a discussion on intuition in 4 parts on our podcast or the YouTube Playlist for Who is Myron Dyal?
#MyronDyal
#WhatIsTLE?
#TemporalLobeEpilepsy
#Epilepsy
#TBI
#Mystic
Key point: The etiology of temporal lobe epilepsy (TLE) influences the formation of ictal scalp EEG patterns.
doi.org/10.1002/epi4...
#epilepsy #ILAE #ictalscalpEEG #ictalthetaactivity #seizureonsetpatterns #seizurepropagationpatterns #temporallobeepilepsy
⚡ Do people with #Epilepsy dream about #Seizures? 🧠💭
Some experience #SeizureDreams where they dream of having a seizure—sometimes waking up to find they had one. 😨
Nocturnal seizures may blend into dreams, especially in #TemporalLobeEpilepsy. 😶🌫️
Sleep & brain activity are deeply linked! 🛌✨
Key point: A correlation between ME and GAD65 antibodies suggests a potential immunological pathogenic mechanism.
doi.org/10.1002/epi4...
#epilepsy #ILAE #antiGAD65 #autoimmuneassociatedepilepsy #foramenovaleelectrodes #musicogenicepilepsy #temporallobeepilepsy
