“Hidden drug storehouses” could explain treatment resistance in cancer One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others.

Why do some #cancer cells develop treatment #resistance? The answer may lie in hidden “storage hubs” inside #tumour cells, which create uneven drug exposure across tumours, according to new #research led by @louisefets.bsky.social from 🇬🇧 @mrc-lms.bsky.social.

#Science #Nature #Pets #Dog #Vaccine #Health #Medicine #MRNA #chatGTP #AlphaFold #DNA #RNA #Immunology #DesignerDrug #TargettedMedicine #Australia #SmallPharma ( #Cancer #Cure? #Treatment ) #Vet #AI #Innovation #Pioneer #genomics #tumour #mutation #disease #Rosie

Abstract: Liquid biopsy is revolutionizing cancer management, with circulating tumor cells (CTCs), offering a transformative approach to screening, diagnosis, and treatment monitoring. However, existing CTC isolation methods relying on antigen expression or physical properties lack robustness, are operator-dependent, and suffer from automation challenges, leading to inconsistent and time-intensive analyses. A universal, unbiased methodology for CTC detection across tumor types is critically needed. Here, we present the first proof-of-concept study demonstrating the use of Fourier transform infrared (FT-IR) microspectroscopy to study cytospun blood samples coupled with a random forest (RF) classifier, for the detection of a single CTC in the blood of a lung cancer patient as confirmed via immunohistochemistry. Notably, our method utilizes glass coverslips as substrates, routinely employed in pathology departments, enabling seamless integration with histopathological analyses (e.g., staining, immunohistochemistry). Using FT-IR spectral data from in vitro growing lung cancer cells as a training model, we achieved precise CTC identification based on biochemical composition, specifically within the fingerprint region (1800 cm–1 to 1350 cm–1). This study introduces FT-IR microspectroscopy as a novel, label-free approach for CTCs detection in liquid biopsies, with the potential to redefine cancer diagnostics. By enhancing precision and accessibility in CTC identification, the clinical implementation of this methodology may represent a significant advancement in personalized oncology, offering a clinically viable tool for real-time cancer monitoring and improved patient stratification.

New from Applied Spectroscopy!
Fourier Transform Infrared Microspectroscopy as a Liquid Biopsy Tool to Detect Single Circulating Tumour Cells in the Blood of a Lung Cancer Patient
More: https://doi.org/10.1177/00037028251390565
#SAS #Spectroscopy #FTIR #Microspectroscopy #circulating #tumour #cells

Adrenal tumours are commonly encountered in every endocrinology practice and related subspecialties nowadays, and require the most accurate evidence-based management, treatment, and follow-up thelancet.com/journals/lan...
#adrenal #tumour
#phaeochromocytomas #paragangliomas #PPGLs

#MedSky #EndoSky

New AI approach enables diagnosis and monitoring of brain tumours Read more about the analysis method!

🧠 Precise #tumour classification — without tumour tissue?

An international team incl. #MedUniVienna developed an #AI-based method to classify #braintumours via genetic material from #cerebrospinalfluid & monitor disease progression.

📖 @natcancer.nature.com​

Finding new biomarkers to match the biological complexity of cancer Advances in artificial intelligence and multimodal data integration are poised to revolutionise cancer diagnostics – but significant challenges remain before these technologies can be routinely deploy...

Advances in #AI and multimodal data integration are poised to revolutionise #cancer diagnostics, but challenges remain. Prof. Manuel Salto-Tellez outlined steps to bridge the gap between complex #tumour biology and current #biomarkers at the #DigitalPathology and AI Europe conference in 🇬🇧 London.

Not all #cancer mutations are equal: new #research shows that a single #mutation hotspot can generate a rich diversity of #tumour behaviours. This insight could open the door to more personalised cancer treatment. http://dlvr.it/TQy3R2

#nextgenbioeng #pred #cancerresearch #tumour #glioblastoma | ETH-Department of Biosystems Science and Engineering (D-BSSE) Great to welcome over 80 participants (+60 online attendees) at the public #NextGenBioeng seminar, organised by ETH Zürich and Roche | #pRED, Institute of Human Biology 🙏🏽 Many thanks to Prof. Johanna...

🙏🏽 Many thanks to Prof. Johanna Joyce from University of Lausanne @unil.bsky.social, Ludwig Institute for Cancer Research🎗️ for her stimulating talk on the #tumour ecosystem at the public #NextGenBioeng seminar @ethz.ch #Roche | #pRED #teamIHB 👇🏽
www.linkedin.com/feed/update/...

The figure shows a pretreatment MRI in a) T1 and b) T2 of a 63-year-old female with a pleomorphic sarcoma in the anterior compartment of the thigh who had neoadjuvant radiotherapy. The blue line is the measurement of oedema at the cranial edge of the tumour.

Oedema tail is associated with aggressive infiltrative tumours; 26% of them had tumour cells that would remain if we resected the tumour with a wide R0 margin, even with preoperative radiation.

#Tumour #Oedema #Sarcoma #Oncology #Orthopedics #OrthoSky #MedSky

ow.ly/HyLM50XXY6T

A mechanical view on #metastasis and the role of #tumour cell viscosity
www.linkedin.com/feed/update/...
#mechanicalforces #biophysics #DanielMueller #biomechanics #ValentinGensbittel

Aspiring paramedic Sienna completes HSC a year after brain cancer diagnosis Just over a year ago Sienna was shocked to discover she had a rare brain cancer. She's taking a new drug to slow its growth, but it's come at great cost. #cancer #brain #tumour #secondary #education

Just over a year ago Sienna was shocked to discover she had a rare brain cancer. She's taking a new drug to slow its growth, but it's come at great cost. #cancer #brain #tumour #secondary #education

'The grief is brutal': Battling the disease that took Abbey away Abbey was "joy on two legs" and now she's gone, another lost to brain cancer. Somehow her family must carry on as the fight for more funding to bring this horror disease to an end continues. #cancer #brain #tumour #medical #research #scientific #lobbying #health

Abbey was "joy on two legs" and now she's gone, another lost to brain cancer. Somehow her family must carry on as the fight for more funding to bring this horror disease to an end continues. #cancer #brain #tumour #medical #research #scientific #lobbying #health

Model, 27, dies days after retiring with emotional post Model Aoi Fujino, 27, dies 5 days after announcing retirement. Japanese gravure idol in top 100 bustiest celebs list battled rare tumour for three years.</p>

🚨 Interesting article by @Weekademia lab from @UniNorthants

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context-dependent tumour suppression and oncogenicity

👉 buff.ly/9KdJjJj

#RareDisease #DuchenneMuscularDystrophy #cancer #tumour
#DMD #duchenne

Saskatoon woman denied travel coverage after lifesaving brain surgery Tammy O'Brien faces financial hardships on a fixed income and said the health ministry refused to cover her travel costs to Edmonton.

Saskatoon woman denied travel coverage after lifesaving brain surgery Tammy O'Brien faces financial hardships on a fixed income and said the health ministry refused to cover her travel costs to...

#Local #News #brain #tumour #Healthcare #Realtime #Saskatchewan #NDP

Origin | Interest | Match

Teen dies of bone cancer after battling strongest tumour doctor had ever seen Mina Popović, 14, died from Ewing sarcoma after battling strongest tumor her US doctor ever saw, with family appealing for help to transport her body home to Belgrade, Serbia.</p>

Lifting cancer's invisibility cloak: Dying tumor cells alert the immune system The immune system provides constant surveillance for the body, aiming to spot and eliminate disease-causing microbes or cancerous cells. But tumor cells develop many features that help them hide from ...

Scientists are finding ways to help the immune system “see” cancers better. New work shows dying #tumour cells can expose internal proteins that alert dendritic cells, improving immune detection. #TCSC #immunesystem
medicalxpress.com/news/2026-01...

Hero surgeons remove ovarian tumour as big as baby from 69-year-old Surgeons removed a 28cm ovarian tumour weighing 6kg, the size of a full-term baby, from a 69-year-old woman in Turin after it caused severe bowel obstruction.</p>

🔥Tumour-enriched amino acid mimic drives in situ assembly of #PROTACs and immune-engaging #nanoparticles, boosting #Tcell activation 14.8× and causing strong tumour regression with minimal toxicity.
ow.ly/WKzy50XQhjE

#Tumour #CancerResearch #Immunotherapy #Nanomedicine

Stumped doctors find huge lump same weight as loaf of bread growing in baby’s stomach Doctors baffled as baby found with bread sized 550g lump in stomach rare neuroglial heterotopia removed in surgery infant recovers and thrives after mystery mass case.</p>

‘I was misdiagnosed with cancer after doctors found my leg riddled with tumours’ Man diagnosed with rare bone condition after cancer scare rebuilds life learns to walk then runs ultras with titanium rod proving grit resilience and gratitude every mile.</p>

Toothache turned out to be deadly tumour – man loses voice and part of face Handyman Jaco Pretorius survives a massive facial tumour and life saving surgery that cost him his voice as he rebuilds his life through faith, family support and ongoing reconstruction needs.

1/2 #Crimean #Tatar #brain #tumour
#TofikAbdulgaziev #prison #activism
🇺🇦🌻🍂🌾🪶🥊💪🏼💔🧠

#Highlight in #MedComm
PPP2R1A Mutation: A Critical Amplifier for Immune Checkpoint Blockade Therapy Efficacy doi.org/10.1002/mco2...

The highlighted article in @nature.com : doi.org/10.1038/s415...

#CancerImmunotherapy #OvarianCancer #Tumour #biomarker

Estimates suggest that 1–10% of the general population currently harbours an #adrenal #tumour, peaking in prevalence in the seventh and eighth decades of life www.thelancet.com/journals/lan...

#MedSky #EndoSky #OncSky

Baby girl born with giant tumour so large it made up one-sixth of her body weight Baby born with giant tumour weighing one sixth of her body has lifesaving surgery after rare teratoma grows rapidly with doctors removing the benign mass just nine days after birth.</p>

Researchers use 3D bioprinted tumor models to transform cancer treatment In associate professor Mauro Tambasco's lab, researchers at all levels work together to develop innovative approaches to fighting cancer.

Researchers are using 3D bioprinted #tumour models to predict treatment responses and personalise cancer therapy. A smarter way to outmaneuver cancer before it gets a chance. #TCSC #CancerResearch #Bioprinting #MedicalScience

medicalxpress.com/news/2025-11...