Gut pathogen Clostridium symbiosum rewires macrophage succinylation to drive enteric neuron loss in inflammatory bowel disease Zhao et al. identify an IBD-enriched gut pathogen, Clostridium symbiosum, that promotes enteric neuron loss and colitis. C. symbiosum-derived succinate rewires macrophage glycolytic metabolism to sustain IL-1β signaling, thereby activating neuronal NLRP3 inflammasomes and driving neuron loss. Targeting C. symbiosum with a phage-derived endolysin preserves enteric neurons and alleviates intestinal inflammation.

#WeekendRead! #EveryCellIsAnImmuneCell! #InflammasomePower! #ImmunometabolismPower! Zhao &co show @cp-cellhostmicrobe.bsky.social that a clostridium enriched in #IBD exacerbates colitis via boosting #glycolysis & IL1b by macrophages & activating NLRP3 in enteric #neurons, causing their loss!

A hazy sky creates silhouettes of leafless trees. In the foreground is historical fiction novel, The Girl from Brittia. The cover features a blond woman in a long blue dress holding a sword. She stands on a beach beneath a sunset sky. Over her is the shadowy outline of a wolf. https://mybook.to/GirlfromBrittia

It was love at first sight.
What could possibly go wrong?

#HistoricalFiction The Girl from Brittia is only #99cents or #99p
mybook.to/GirlfromBrit...
#eBook #paperback #KindleUnlimited #WeekendRead #KindleCountdownDeal

The books are also in Kindle Unlimited, so if you're a KU subscriber, you can read both for free.
Mirrors book link: mybook.to/MrsHudson1
Shadow book link: mybook.to/MrsHudson2
Have a great weekend!
#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 6/6
#phew

A House of Mirrors: A twisty Sherlock Holmes historical mystery (Mrs Hudson & Sherlock Holmes Book 1) Amazon.com: A House of Mirrors: A twisty Sherlock Holmes historical mystery (Mrs Hudson & Sherlock Holmes Book 1) eBook : Hedgecock, Liz: Kindle Store

A House of Mirrors (Mrs Hudson & Sherlock Holmes book 1) is FREE in ebook on ALL AMAZON STORES until April 14!
PLUS
In Sherlock's Shadow (Mrs Hudson & Sherlock Holmes book 2) is 0.99 in ebook in the US and UK until April 17!

#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 5/?

...(I want to see what my alpha reader makes of it before it goes to beta-readers!). I also did admin, booked in another client edit and sent some enquiry emails.

But now, the offer!

#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 4/?

A House of Mirrors: A twisty Sherlock Holmes historical mystery (Mrs Hudson & Sherlock Holmes Book 1) Amazon.com: A House of Mirrors: A twisty Sherlock Holmes historical mystery (Mrs Hudson & Sherlock Holmes Book 1) eBook : Hedgecock, Liz: Kindle Store

This week’s been a short working week because of Easter, which was very nice. However, I finally managed to edit the odd little 1950s-set novella I wrote late last year and it has gone for an alpha read...

#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 3/?

2) I’m going to start the read through of the draft of Maisie Frobisher book 7 when I come off here and I’m both apprehensive and excited, even though I know what happens!

#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 2/?

Happy Friday! Time for the weekly update...

I’m posting earlier than I normally do on a Friday for 2 reasons:
1) I have an OFFER to share with you!

#booksky #sherlock #historicalmysteryseries #bookbargain #weekendread 1/?

Parasites trigger epithelial cell crosstalk to drive gut–brain signalling - Nature Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occu...

#WeekendRead! #EveryCellIsAnImmuneCell! Julius, Touhara &co show @nature.com that, during gut #elminth infections, tufts cells release acetylcholine in 2 waves to induce serotonine secretion by enterochromaffin cells, activating vagal nerve to suppress food intake! www.nature.com/articles/s41...

An illustration of Charles Trevelyan during the Irish Famine, surrounded by suffering families, laborers, and stormy skies.

Charles #Trevelyan: The #controversial civil servant who shaped Ireland’s great #famine
A compelling look at Charles Trevelyan, the British civil servant
#IrishHistory #GreatFamine #CharlesTrevelyan #HistoricalFeature #WeekendRead #EuropeanHistory
juskosave.blogspot.com/2026/04/char...

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…

#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!

The backdrop of a dawn sky with orange and pink clouds displays historical fiction novel Dawn of the Franks - the story of Basina of Thuringia. The cover features a backdrop of trees silhouetted against an orange sky and the rising sun. In the foreground a blonde man kneels before a medieval couple. A dark-haired man in a red tunic has his arm around a woman with a white mantle and a fur cloak. The text reads 'The might of Rome has waned. And the sun is rising on the Dark Ages'. https://mybook.to/DawnoftheFranks

Bitter betrayal. forbidden romance, and a love story to transform history...

#HistoricalFiction Dawn of the Franks - the story of Basina of Thuringia
mybook.to/DawnoftheFra...
#eBook #paperback #KindleUnlimited #weekendread 📚⚔️

Robots in the Garden A different way to think about your PKM system — and roles AI can play in it.

Really great ideas here from Jorge Arango on using AI chat tools for research, learning, and deep thinking.

Perfect long read for the weekend.

#weekendread

jarango.com/2026/03/27/r...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

#WeekendRead! #RemeberMe! @snaga13.bsky.social @jbuenrostro.bsky.social &co show @nature.com that intestinal stem cells remember multiple cycle of inflammation by epigenetically favoring AP-1 accessibility, thus increasing proliferation & repair, but also favoring tumorigenesis!

In the background, a pale sun peers over the top of a hill through a hazy red sky. Below it the trees are leafless and there is snow on the ground. Over it is historical fiction novel Tyrant Whelp with the cover featuring the hooded face of a man and a sword protruding from a stone. The text reads In Britannia King Arthur presides over a golden age... But as the sun shines without brightness, the realm is plunged into a wasteland of ice, famine and a war where many of its finest must fall. Yet for Custennin of Dumnonia, greatness beckons. Is he up to the task? Tyrant Whelp https://mybook.to/TyrantWhelp

A kingdom in ruins. A throne up for grabs. And the man who inherits it? Not a hero.
Power corrupts. Loyalty shatters. Who will survive Camelot’s fall?
#Arthurian #HistoricalFiction Tyrant Whelp is only #99cents or #99p
mybook.to/TyrantWhelp
#WeekendRead #KindleCountdownDeal #Bargain 📚⚔️

A purple background displays historical fiction novel God's Maidservant - the story of Adelaide of Italy. The cover features a blonde woman in a red and black medieval dress in front of a stone abbey. The text says 'Throughout an unhappy marriage and a tormented widowhood, only faith sustains the Italian queen. Will King Otto of Germany be the answer to Adelheid's prayers? https://mybook.to/GodsMaidservant

“You will be my wife one day, Adelheid. Why not agree to it willingly?”
God's Maidservant - the story of Adelaide of Italy
mybook.to/GodsMaidserv...
#HistoricalFiction #WeekendRead #eBook #paperback #KindleUnlimited ⚔️📚

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they...

#WeekendRead! #SkinGutAxis! Wu &co show @cp-cellmetabolism.bsky.social that #psoriasis induces a population of #intestinal macrophages that produce #IL1b & alters lipid absorption, increasing epithelial lipid accumulation, thus fostering gut inflammation!

A valley of rocks and trees in autumnal colours displays historical fiction novel The Saxon Marriage. The cover features a woman in a red and turquoise medieval dress embracing a man in armour. The text reads: Enemies muster on the border, but the deadliest of foes lurk much closer to home... https://mybook.to/SaxonMarriage

A troubled Wessex princess.
The young hope of Saxony.
An ancient bloodline.
An upstart dynasty.
Will The Saxon Marriage be a happy one?

Only #99cents or #99p for one week only! mybook.to/SaxonMarriage
#HistoricalFiction #KindleCountdownDeal #WeekendRead #BargainBook 📚👸

The impossible task of caring for ageing parents who did not care for you: ‘There’s a lot of reliving old triggers’ It’s hard under the best of circumstances. For those with difficult family relationships or estrangement, it’s even more complicated

#WeekendRead

Ageing
The impossible task of caring for ageing parents who did not care for you: ‘There’s a lot of reliving old triggers’
It’s hard under the best of circumstances. For those with difficult family relationships or estrangement, it’s even more complicated

Five Fatal Flaws for Friday?
#WeekendRead

Wow! For a limited time both THE ART OF THE DECOY and A WEATH OF DECEPTION audiobooks are 1.99 . Only on Chirp . If you enjoy #audiobooks you'll never get then at a better deal. #audiobookdeal #bookdeal #WeekendRead #awardwinning #bookseries #mysterynovel #antiquedealer #Vermont

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

#WeekendRead #MysterySolved! MYC is one of the most famous #oncogenes & a potential therapeutic target but how does it work? Uhl, Eilers &co show @cp-cell.bsky.social that MYC binds introns during RNA stalling preventing export of dsRNA & DNA/RNA hybrids & anti-tumoral TLR3 activation!

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

State Property Tax Reform Efforts Continue Amid Local Fiscal Strains In the years following the COVID-19 pandemic, lawmakers have repeatedly pursued measures to cut property taxes—or even eliminate them. But such initiatives often bring new fiscal pressures. They can c...

Important #WeekendRead: The Pew Charitable Trusts recently wrote about the consequences of property tax cuts on local government services. Check it out: www.pew.org/en/research-...

In the background, a pale sun peers over the top of a hill through a hazy red sky. Below it the trees are leafless and there is snow on the ground. Over it is historical fiction novel Tyrant Whelp with the cover featuring the hooded face of a man and a sword protruding from a stone. The text reads In Britannia King Arthur presides over a golden age... But as the sun shines without brightness, the realm is plunged into a wasteland of ice, famine and a war where many of its finest must fall. Yet for Custennin of Dumnonia, greatness beckons. Is he up to the task? Tyrant Whelp https://mybook.to/TyrantWhelp

A kingdom in ruins. A throne up for grabs. And the man who inherits it? Not a hero.
Power corrupts. Loyalty shatters. Who will survive Camelot’s fall?

#Arthurian #HistoricalFiction Tyrant Whelp mybook.to/TyrantWhelp
#eBook #paperback #KindleUnlimited #WeekendRead

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

The backdrop of a dawn sky with orange and pink clouds displays historical fiction novel Dawn of the Franks - the story of Basina of Thuringia. The cover features a backdrop of trees silhouetted against an orange sky and the rising sun. In the foreground a blonde man kneels before a medieval couple. A dark-haired man in a red tunic has his arm around a woman with a white mantle and a fur cloak. The text reads 'The might of Rome has waned. And the sun is rising on the Dark Ages'. https://mybook.to/DawnoftheFranks

Bitter betrayal, forbidden romance, and a love story to change the course of history...

#HistoricalFiction Dawn of the Franks - the story of Basina of Thuringia
mybook.to/DawnoftheFra...
#eBook #paperback #KindleUnlimited #WeekendRead #WomensHistoryMonth

HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...

#WeekendRead! #MisterySolved! Overstreet Messer &co show @cp-cellhostmicrobe.bsky.social that HMGB1 in the gut mucus broadly targets a bacterial virulence factor preventing bacterial mucus invasion & tissue adhesion! #IBD is associated with low HMGB1!