#Renal focal global #glomerulosclerosis relates to #aging and #hypertension and begins with tuft contraction of #glomeruli. This report shows associated #biomarkers of #podocyte depletion, cell #senescence, and activation of #parietal #epithelia #cells.
doi.org/10.14814/phy...
#Kidney #Physiology

This image by Frederic Bonnet @mdibl-lmf.bsky.social shows pathways within renal #glomeruli (filtering units) from a mouse's kidney section. Blue delineates the delicate scaffolding of #actinfilaments, while orange reveals the #glycoproteins enmeshing the #vasculature. 🧪 🤝 👩‍🔬

#microscopymonday

Crosstalk between glomeruli and tubules - Nature Reviews Nephrology Glomerular injury and damage to the glomerular filtration barrier can promote the development of tubulointerstitial fibrosis. Here, the authors discuss potential mechanisms underlying this effect, as ...

Explore the #kidney where #glomeruli & #tubules crosstalk, revealing complex pathways in chronic kidney disease. Injury in glomeruli can exacerbate tubular damage. #Science #Medicine #Health PMID:39643696, Nat Rev Nephrol 2024, @NatRevNeph doi.org/10.1038/s415...

#SpatialTranscriptomics #GeoMx #ChronicKidneyDisease
#AlportSyndrome
#FocalSegmentalGlomerulosclerosis
#MembranousNephropathy

#Glomeruli vs Tubules

Pathology score
➕corr: Retinoic acid binding
➖corr: Selenocysteine synthesis; SLIT/ROBO

#JCIInsight 2024
insight.jci.org/articles/vie...

With the help of the brilliant Hani Suleiman, we show that you can study the structure and morphology of #glomeruli - specifically #podocytes and their foot processes.

No need to do TEM to analyze these structures to study foot process effacement anymore!

Verification of kidney biopsy adequacy with portable digital microscope #KidneyBiopsyAcademy #glomeruli @PJMartinezPitre @Mohammadmnasrah @SamShuaibi @OchsnerNephro

My bias pick #NephMadness 2017 is of course from the #glomeruli region : anti pla2r for membranous GN