The benefits of #Semaglutide on Blood Pressure & Renal Functions (Not food intake/blood glucose) are dependent on GLP1R in Myh11+ arterial/arteriolar smooth muscle cell (Not Tie2+ endothelial/myeloid cell) in 🐭kidney

@danieljdrucker.bsky.social #JCIInsight 2026
insight.jci.org/articles/vie...

Correction #JCIInsight

JCI Insight - Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk

Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk #JCIInsight #MassSpec insight.jci.org/articles/vie...

Anatomy of Intimomedial Tears (uncomplicated partial mural tears with minimal [mm-level] medial delamination) in👤ascending aortas
N=9/108👤aortic surgeries

3 fates
1⃣Healed by neointimal #SmoothMuscleCell
2⃣#AorticDissection
3⃣#AorticRupture

#AortaEd
#JCIinsight 2024
insight.jci.org/articles/vie...

#SpatialTranscriptomics #GeoMx #ChronicKidneyDisease
#AlportSyndrome
#FocalSegmentalGlomerulosclerosis
#MembranousNephropathy

#Glomeruli vs Tubules

Pathology score
➕corr: Retinoic acid binding
➖corr: Selenocysteine synthesis; SLIT/ROBO

#JCIInsight 2024
insight.jci.org/articles/vie...

Condition Tie2+ Monocyte/Mφ to treat #LimbIschemia
siRNA HTATIP2⏫NRP1+Angpt1

Tie2+ Mφ from #ChronicLimbThreateningIschemia👤exhibits ⏬angiogenic+arteriogenic benefit in vitro & in🐭

Alberto Smith, Bijan Modarai labs #JCIInsight 2023
insight.jci.org/articles/vie...

Landmark Revisit

Proteoglycanomics of human #AscendingAorta Non-Dilated n=8 vs #AorticAneurym n=36 + acute type A #AorticDissection n=21

#AortaEd

ADAMTS5 as a potential cleaving enzyme for aortic Versican Aggrecan

Suneel Apte lab #JCIInsight 2018
insight.jci.org/articles/vie...

ABT-263, a broadly-used #Senolytic agent
⏫Mortality of atherosclerotic🐭
Unaltered plaque burden
⏫Plaque instability

An interesting shifting of cellular sources to athero-lesions
⏬SMC progenies
⏫#EndothelialCell progenies (#EndMT?)

#JCIInsight 2024
insight.jci.org/articles/vie...

scRNAseq👤#PreretinalFibrovascularMembrane
#DiabeticRetinopathy
N=4

AEBP1➡️#Pericyte-to-Myofibroblast transformation

Pericyte-#EndothelialCell
VEGFA-FLT1/KDR

Myofibroblast/SMC-EC
Sema3C-Nrp2; VEGFA/VEGFC-FLT1/KDR/FLT4

#JCIInsight 2023
insight.jci.org/articles/vie...