PGAM1-Chk1-HIF-2α signaling axis activates FoxM1 to drive metabolic reprogramming & survival in #SenescentCells, showing that pharmacological disruption of the PGAM1-Chk1 interaction acts as a targeted #Senolytic to eliminate these cells.
#OpenAccess: doi.org/10.1038/s413...
#NaturalKiller #Senolytic #Lung
NK (Ncr-iCre) TGFβRII KO ▶️
Normal🫁
👉⏬Arteriolar vol
👉 #PulmonaryHypertension
👉Postnatal alveolar dilation ⏬Inflation compliance ♂️only
Hyperoxic 🫁 👉Rescue #BronchoPulmonaryDysplasia
TGFβ deficiency➡️
⏫senolytic NK➡️
⏬ #Senescence🫁
www.biorxiv.org/content/10.1...
SYMPOSIUM OUTLOOK: Cancer mortality and senescence: Is redox therapy an option?
By Shan Kuang, Manojit Swamynathan, & Lloyd C. Trotman
➡️ https://bit.ly/4fFk3zg
#cshlsymp25 #senescence #cancer #metastasis #prostatecancer #pro-oxidants #redox #lysosome #senolytic #cancertherapy #aging #biomarkers
#SpatialTranscriptomics #Atherosclerosis
Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions
scRNAseq GeoMx
🔥 #SmoothMuscleCell Fibroblast T
#Senolytic ABT-737 ⏫plaque collagen fibers ⏬necrotic core ⏬serum cytokines
#NatAging 2025
www.nature.com/articles/s43...
Developmental vs Neonatal Hyperoxia-induced #Senescence in🐭Lung
Both p21-dependent
AT2, mesenchymal cell, secondary crest myofibroblasts are senescent
Development
❎DNA damage
❎SASP
Disrupted by p21 KO
Hyperoxic injury
✅DNA damage
✅SASP
⬇️by #Senolytic
#NatComm 2023
www.nature.com/articles/s41...
Targeting cIAP2 in a novel #senolytic strategy prevents #glioblastoma recurrence after #radiotherapy
By B. Mukherjee, S. Burma & colleagues at University of Texas
➡️ doi.org/10.1038/s443...
Casein kinase 2 inhibitor, TBB as a novel #Senolytic
TBB quenches DDR in senescent cells▶️
⏫unrepaired DNA damage
⏫Apoptosis
in Zmpste24 KO🐭
extends lifespan (18->24 wk)
⏫trabecular bone vol
⏬#CellularSenescence in kidney spleen
#CellDeathDis 2024
www.nature.com/articles/s41...
"Stress-Induced Premature #Senescence and #Senolytic Intervention for Therapeutic Implications in the Adipose Stromal Vascular Niche" - Marlene Wahlmüller presenting her research at #TERMIS2024 in Seattle.
ABT-263, a broadly-used #Senolytic agent
⏫Mortality of atherosclerotic🐭
Unaltered plaque burden
⏫Plaque instability
An interesting shifting of cellular sources to athero-lesions
⏬SMC progenies
⏫#EndothelialCell progenies (#EndMT?)
#JCIInsight 2024
insight.jci.org/articles/vie...
