mRNA vaccination facilitates the prevention and control of infectious diseases at an unprecedented speed

Elucidating how the #mRNAVaccine technology offers a transformative paradigm in global health by providing a flexible, scalable, & rapid-response platform that elicits potent #ImmuneResponses, highlighting the challenges & future perspectives.
#OpenAccess: doi.org/10.1016/j.dc...

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

This review explores proton‑activated #GPCRs, pH‑sensing receptors that modulate #ImmuneResponses, highlighting their roles in #InflammatoryDiseases and future directions for understanding immune regulation under pathological conditions.
Read: doi.org/10.1007/s115...

This review illustrates the interplay between the immune system and #CardiovascularDiseases, describing the regulation of #ImmuneResponses in #CVDs, the strategies targeting immunity and their implications in CVDs. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1038/s413...

mRNA revitalizes aging immune systems: The liver as a fountain of youth – BioNews Central Researchers demonstrated that mRNA technology can temporarily reprogram the liver in older mice to produce essential immune factors, restoring the generation of new immune cells and enabling strong immune responses to effectively combat tumors. ...

Researchers demonstrated that #mRNATechnology can temporarily reprogram the #liver in older mice to produce essential #ImmuneFactors, restoring the generation of new #ImmuneCells and enabling strong #ImmuneResponses to effectively combat #tumors.
#ImmuneAging #AntiAgingTherapy

New research in #RESMedVetEnt

#Hippobosca equina: Influences on oxidative stress and immune-regulating cytokine responses in horses
doi.org/10.1111/mve.70041

#Ectoparasites #ImmuneResponses #OxidativeStress #Equines #Physiology
@wileyeco.bsky.social

baseline IFN-y production by innate lymphocytes correlated with #SARSCoV2 Spike-specific #immuneresponses. In vitro mRNA stimulation also induced IFN-y production, which was TLR8-dependent & reduced in rural Indonesians.

Current Advances in Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Severe Fever with Thrombocytopenia Syndrome Virus vaccines target glycoproteins and NP; review highlights platforms and immune responses.

Exploring the various #VaccinePlatforms for tick-borne severe fever with #Thrombocytopenia syndrome virus (SFTSV), with highlights into the #ImmuneResponses elicited by these platforms and future directions to accelerate development of effective SFTSV #vaccines.

#OpenAccess: tinyurl.com/2yc7r74t

Engineered gut bacteria improves survival outcomes in colorectal cancer tumors – BioNews Central In a new study that combines synthetic biology with cancer immunotherapy, researchers have developed an engineered strain of gut-homing bacteria that stimulates potent antitumor immune responses against colorectal cancer. ...

In a new study that combines #SyntheticBiology with #CancerImmunotherapy, researchers have developed an #engineered strain of gut-homing #bacteria that stimulates potent #antitumor #ImmuneResponses against #ColorectalCancer. 
#GutBacteria

Drawing on evaluation reports & guidance from major regulatory bodies & scientific reviews, the nonclinical assessment of #COVID💉 shows an overall favourable safety profile. Animal studies primarily revealed expected #immuneresponses & local, reversible inflammation, rather than adverse events.

Plant-derived nutrient zeaxanthin improves immune cells’ ability to fight cancer – BioNews Central Zeaxanthin — a plant-derived carotenoid best known for protecting vision — may also strengthen immune responses by increasing the cancer-fighting activity of immune cells. ..

#Zeaxanthin — a #PlantDerived #carotenoid best known for protecting #vision — may also strengthen #ImmuneResponses by increasing the #CancerFighting activity of #ImmuneCells.
#AntiTumorImmunity

Gut neurons help the body fight inflammation – BioNews Central Gut neurons produce a molecule that shapes immune responses during and after inflammation, suggesting new therapeutic targets for inflammatory bowel disease and related gut disorders. ...

#GutNeurons produce a molecule that shapes #ImmuneResponses during and after #inflammation, suggesting new #TherapeuticTargets for #InflammatoryBowelDisease and related #GutDisorders.

Describing the interplay between energy metabolism alterations & #ImmuneResponses in #HNSCC, the key molecular players, and the therapeutic relevance of targeting #MetabolicReprogramming in HNSCC. #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization - Nature Biomedical Engineering Floss-based vaccination exploits the leaky junctional epithelium of the gingival sulcus to deliver different types of vaccine, inducing robust mucosal and systemic immunity and providing protection ag...

Dental floss as a #vaccination strategy? This study shows that floss-based vaccination can deliver protein, inactivated virus, peptide-presenting immunogenic nanoparticles, mRNA & induces #immuneresponses protecting against infectious disease in mice ➡️ www.nature.com/articles/s41... #immunity

🎉 Excited for #BaCell3D 2025 in Basel 🇨🇭 tomorrow! Our team can’t wait to connect, share insights, and get inspired by cutting-edge 3D #CellCulture science! Interested in #OrganOnChip, #MicrophysiologicalSystems, #Cancer immunology, adaptive #ImmuneResponses, or #NeuronalNetworks? Come say hi! 👋

A joint research by KAIST and Florida State University discovered the mechanism by which double-stranded #RNA derived from #mitochondria in cells amplifies #immuneresponses. They identified the protein SLIRP as an immune switch that regulates this process. www.cell.com/cell-reports...

Conserved Chromatin Regulators Control the Transcriptional Immune Response to Intracellular Pathogens in Caenorhabditis Elegans | Newswise In this study, we show that transcriptional regulators, previously linked to development in Caenorhabditis elegans, also control immune responses. Through forward genetic screens, we found that loss o...

Conserved Chromatin Regulators Control the Transcriptional Immune Response to Intracellular Pathogens in Caenorhabditis Elegans
www.newswise.com/articles/con...
#geneticscreening #immuneresponses #Geneexpression #mutations #intracellularpathogens #immunesupport

The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer

This review investigates the interplay between energy metabolism alterations & #ImmuneResponses in #HNSCC, highlights the key molecular players, and explores the therapeutic significance of #MetabolicReprogramming in HNSCC. #medsky

#OpenAccess: buff.ly/UESORJn

mRNA-Coronaimpfung trainiert das „Langzeitgedächtnis“ des Immunsystems Forschende der Universität zu Köln zeigen, dass COVID-19-Impfstoffe auf der Grundlage von mRNA das angeborene Immunsystem langfristig prägen. Diese Mechanismen können bewirken, dass der menschliche Kö...

🧬💡 #mRNA vaccines against COVID-19 not only trigger classical #immuneresponses, but also have a persistent effect on the innate #immunesystem📚
That shows a study by the team of Jan Rybniker and @epistrucstab.bsky.social #UniCologne in Molecular Systems Biology @embopress.org🦠👇
uni.koeln/43N7Y
#covid

Mount Sinai-Led Team Identifies Cellular Mechanisms That May Lead to Onset of Inflammatory Bowel Disease | Newswise New study shows that dysfunction of protective immune cells in GI tract may contribute to onset of inflammation in Crohn’s disease

Mount Sinai-Led Team Identifies Cellular Mechanisms That May Lead to Onset of Inflammatory Bowel Disease
www.newswise.com/articles/mou...
#inflammatory #crohnsdisease #gastrointestinaltract #diseasedevelopment #inflammation #immuneresponses #immunecells

With an interdisciplinary team, we will
🔬 Simulate human #ImmuneResponses in the context of #Cancer using #Organoids & #OrganOnChip tech
🧬 Advance #PersonalizedMedicine, #Therapies & #Vaccines
Over 6 years, we aim to advance #Immunotherapy & #PatientCare. Stay tuned—and we’re #Hiring! 🚨 #ScienceJobs

Immune perturbations induced by SARS-CoV2 in infants vary with disease severity and differ from adults’ responses Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies have been reported from infants hospitalized with severe disease. We ...

#MedSky🧪#IDSky #PedSky #ImmunoSky These findings provide new insights into the distinct #immuneresponses to #SARSCoV2 in 1st year of life & underscore the importance of further defining the unique features of early life immunity. www.researchsquare.com/article/rs-5...

#MedSky🧪#IDSky #PublicHealth #ImmunoSky #Viralimmunology #Immunity acquired by vaccination following infection, termed #hybridimmunity, has been shown to confer enhanced protection against severe #COVID by enhancing the breadth & potency of #immuneresponses .

Combined COVID-19, Flu Vaccine Candidate Headed to Phase 3 Trials An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza and COVID-19 induced virus-specific immune responses in people

MedSky🧪 IDSky #PublicHealth #ClinicalTrial #Drugsdevelopment
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza & #COVID19 induced virus-specific #immuneresponses in people who received it
jamanetwork.com/journals/jam...