Tofacitinib and Iguratimod Combination Shows Promise in PPF Tofacitinib and iguratimod show dual efficacy in controlling synovitis and pulmonary fibrosis, according to a new study.

#Tofacitinib combined with #Iguratimod shows dual efficacy in controlling #Synovitis and #LungFibrosis. Study in Frontiers in Immunology.

Read more: https://bit.ly/4tqBIkB

#RareDisease #Immunology #ProgressivePulmonaryFibrosis

AI Tools Reveal How IPF and Aging Are Connected - Aging-US Research Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease that primarily affects people over the age of 60. It causes scarring in the lung tissue, which gradually reduces lung capacity and mak...

✅ Read our #blog post about the #research paper, "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

#Summary ⬇️
aging-us.org/2025/09/ai-t...

#aging #ipf #ai #proteomics #lungfibrosis #oa #peerreview #publishing #TrendingWithImpact

AI Tools Reveal How IPF and Aging Are Connected - Aging-US Research Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease that primarily affects people over the age of 60. It causes scarring in the lung tissue, which gradually reduces lung capacity and mak...

✅ Read our #blog post about the #research paper, "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

#Summary ⬇️
aging-us.org/2025/09/ai-t...

#aging #ipf #ai #proteomics #lungfibrosis #oa #peerreview #publishing #TrendingWithImpact

#research call! ILFA has received funding for a VPR pilot for #lungfibrosis patients in 2026. We need a #study partner-please share with anyone you think would be interested. Deadline for expressions of interest is 9th of January. More info: ilfa.ie/blog/urgent-... #ipf #ppf #ild #pulmonaryfibrosis

A lactate-driven PGAM1–Chk1 interaction sustains #glycolytic reprogramming and #DNARepair in #SenescentCells via HIF-2α/FoxM1 signaling; disrupting this axis induces #senolysis, improves #aging phenotypes, and reduces #LungFibrosis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

AI Tools Reveal How IPF and Aging Are Connected - Aging (Aging-US) Research Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease that primarily affects people over the age of 60. It causes scarring in the lung tissue, which gradually reduces lung capacity and mak...

✅ Read our #blog post about the #research paper, "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

#Summary ⬇️
aging-us.org/2025/09/ai-t...

#aging #ipf #ai #proteomics #lungfibrosis #oa #peerreview #publishing #TrendingWithImpact

This study shows that interfering with miR-17 can significantly reduce #LungFibrosis in #AcuteRespiratoryDistressSyndrome (ARDS) by regulating Mfn2, positioning miR-17 as a #therapeutic target in #ARDS-related lung fibrosis. #medsky
Read:
link.springer.com/article/10.1...

While the exact cause of #LungFibrosis isn't fully understood, risk factors increase the likelihood:
– Smoking
- Environmental/Occupational Exposure
– Conditions like GORD
– Genetic links
Knowing the risks can help you get diagnosed earlier

#PFAwareness #EveryBreathMatters #PulmonaryFibrosis

AI Tools Reveal How IPF and Aging Are Connected - Aging (Aging-US) Research Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease that primarily affects people over the age of 60. It causes scarring in the lung tissue, which gradually reduces lung capacity and mak...

✅ Read our #blog post about the #research paper, "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

#Summary ⬇️
aging-us.org/2025/09/ai-t...

#aging #ipf #ai #proteomics #lungfibrosis #oa #peerreview #publishing #TrendingWithImpact

Diagnosing #LungFibrosis isn't always straightforward but timely and accurate testing helps.
Combining diagnostic tools and evaluation methods give clinicians a clearer picture, and a clearer picture means better care.

#LFAwarenessMonth.
#PFAwareness #EveryBreathMatters #PulmonaryFibrosis

📈 #TrendingWithImpact:
A new #research paper was #published on August 8, titled “AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.”

🔗 doi.org/10.18632/agi...

#aging #quote #IPF #lungfibrosis #proteomics #ai #oa #journal #publishing

🎥 #AgingShort:
Abstract #video about this #research paper recently #published in Volume 17, Issue 8, titled "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

🔗 doi.org/10.18632/agi...

#aging #TrendingWithImpact #IPF #lungfibrosis #proteomics #ai #oa

Navigating a new lung fibrosis diagnosis can be overwhelming, but you're not alone.

ILFA has lots of resources available on our website: www.ilfa.ie. Just one quick reference: ilfa.ie/wp-content/u...

#LFAwarenessMonth.
#PFAwareness #EveryBreathMatters #PulmonaryFibrosis #LungFibrosis

‘I’m now on 10 litres of oxygen a day’ – Wicklow man describes living with lung fibrosis A former Wicklow Fine Gael local election candidate, who was hugely active in almost every sphere of community life, has described having to cope with “frightening” moments every day, due to a life-li...

For today's post, one of our wonderful patient advocates, Lorcan McMahon, describes his journey with #lungfibrosis www.independent.ie/regionals/wi... #LFAwarenessMonth.
#PFAwareness #EveryBreathMatters #PulmonaryFibrosis

ilfa.ie/lung-fibrosi... Today is the start of Lung Fibrosis Awareness Month 2025. Our #EveryBreathMatters campaign will highlight the everyday realities faced by lung fibrosis patients and caregivers. We hope you'll share our content and help us reach 1 million people! #PFMonth #LungFibrosis

JCI Insight - Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis

Deficient #AMPK signaling in AT2 cell dysfunction as druggable signaling hub to mitigate #LungFibrosis in vivo insight.jci.org/articles/vie... #DrugDevelopment #PulmonaryResearch #TranslationalScience

NDM's Respiratory Medicine Unit, @imm.ox.ac.uk and @newcastleuni.bsky.social have mapped out the first atlas to show cell interaction in #LungFibrosis. With support from the @oxfordbrc.bsky.social, the team's work could explain why lungs fail to repair in #IPF 🫁🗺️

Read more 👉 buff.ly/rBDDxvR

Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis

@atscommunity.bsky.social‬ #LungFibrosis

www.atsjournals.org/doi/full/10....

Lung Fibrosis patients demand urgent reform amid growing crisis in care Lung Fibrosis is a progressive, life-limiting condition that causes scarring of the lungs, making breathing increasingly difficult

Thanks to @irishmedicaltimes.bsky.social for helping us get the word out about #lungfibrosis! www.imt.ie/news/lung-fi...

An Advocacy Update from our CEO - Irish Lung Fibrosis Association It’s been a very busy week for lung fibrosis! Pictured(left to right) K McVicker, MD […]

We've been very busy advocating for better #lungfibrosis care this week! ilfa.ie/blog/an-advo...

Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis

@atscommunity.bsky.social #LungFibrosis

www.atsjournals.org/doi/full/10....

It's shocking that there is no disease registry for #lungfibrosis in Ireland. As Jack Welch used to say, "You can't manage what you can't measure!". It's great to see this strategy for establishing registries published. Well done Future of Registries Taskforce! cfri.ie/wp-content/u...

Congrats to Sylvia Knapp and team on their new Science Immunology paper! They show how aged bone marrow drives lung fibrosis by sustaining profibrotic macrophages. Reduced T-reg IL-10 worsens healing, revealing key immune-aging links.

www.science.org/doi/10.1126/...

#Immunology #LungFibrosis

ILFA at the Rare Disease Research Conference yesterday. From left to right: Colin Edwards, @eddy767.bsky.social, Liam Galvin, Kelly McVicker and Gemma O'Dowd.

An absolutely fabulous day and huge thanks to @rarediseasectn.bsky.social for helping us get the word out about #lungfibrosis!

Impact of A Multidisciplinary Team Discussion for Genetic #LungFibrosis
onlinelibrary.wiley.com/doi/10.1111/...

TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity | Nature Communications Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. Here we show that triggering receptors expressed on myeloid cells 2 are predominantly expressed on monocyte-derived alveolar macrophages in fibrotic mouse lungs and are significantly elevated in lung macrophages from patients with idiopathic pulmonary fibrosis. Deletion or knockdown of this receptor disrupts intracellular survival signaling, promotes macrophage apoptosis, and attenuates their pro-fibrotic phenotype. We further demonstrate that a lipid mediator and a high-avidity ligand of this receptor, encountered by macrophages in the alveolar milieu, enhance macrophage survival and activity. Ablation of TREM2 or blocking this receptor with soluble receptors or specific antibodies effectively alleviates lung fibros

TREM2 boosts lung fibrosis by enhancing alveolar macrophage survival and activity in fibrotic lungs. Key for new therapies. #LungFibrosis PMID:39971937, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57024-0 #Medsky #pharmasky 🧪

Infusion of bone marrow mononuclear cells reduces lung fibrosis but not inflammation in the late stages of murine silicosis - PubMed We hypothesized that infusion of bone marrow mononuclear cells (BMMCs) in the late stages of silica-induced damage would reduce the remodelling process in a murine model of silicosis. C57BL/6 mice wer...

#tbt #2014 my second first-authored paper. Here, we found that #celltherapy mitigates #lungfibrosis but not #inflammation in experimental #silicosis. Such effects were associated to reduction of macrophage count and expansion of Treg cells. 🧑🏻‍🔬🔬🫁

pubmed.ncbi.nlm.nih.gov/25299237/