This #STTT review discusses the molecular mechanisms and therapeutic landscape of #MitochondrialDiseases, highlighting how targeted interventions in mitochondrial function provide a promising avenue for clinical treatment.
#OpenAccess: doi.org/10.1038/s413...
It’s #BrainAwarenessWeek! Many #MitochondrialDiseases can have negative implications for brain health. That’s because the brain requires a massive amount of energy, which can only be sufficiently produced when mitochondria are functioning well. #UMDF #Biosky
Today is #RareDiseaseDay. We stand with the 300 million people globally who live with a rare disease, including those with rare #MitochondrialDiseases like #MELAS. Read stories of #RareDisease heroes: www.rarediseaseday.org/heroes/ #Biosky
A team of researchers led by Dr Albert Quintana has identified the mechanism behind a potentially fatal type of epilepsy, a symptom of #mitochondrialdiseases
Read the article: cutt.ly/2r7yUBrl
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Tonight, landmarks, buildings & monuments around the world will light up in GREEN to shine a light on #MitochondrialDiseases. This display raises visibility, sparks conversations & shows solidarity with the mito community. #LightUpForMito #WorldMitoWeek2025 #Biosky mitopatients.org/light-up-for...
Mitochondria are known as “the powerhouse of the cell,” generating ~90% of the energy our bodies need and playing a critical role in many different bodily systems and organs. #MitochondrialDiseases have broad and debilitating consequences. #WorldMitoWeek2025 #DecodeTheMitoPuzzle #Biosky
#WorldMitoWeek2025 starts today! This advocacy week is intended to raise awareness about #MitochondrialDiseases with a goal of improving the lives of people affected by these diseases. Join us in supporting this global community! #MitochondrialDisease #DecodeTheMitoPuzzle #Biosky
An overview of the therapeutic mechanisms & advancements in engineered #mitochondria, with a summary of their potential clinical implications and supporting evidence from #ClinicalTrials. #MitochondrialDiseases #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
We’re on a mission to deliver medicines that address what matters most for people with #MitochondrialDiseases, beginning with MELAS and our Phase 2b PRIZM study. Learn more: www.tisentotx.com/prizm #ClinicalResearch #NowEnrolling #RareDisease
Exploring the physiological mechanisms of mitochondria, the mechanisms underlying #MitochondrialDiseases, their potential diagnostic & therapeutic applications, as well as future perspectives on mitochondrial diseases. #medsky
#STTT #OpenAccess: www.nature.com/articles/s41...
#DidYouKnow: International Mito Patients (IMP) is a network of 18 patient organizations, spanning 3 continents, that support people with #MitochondrialDiseases globally. IMP also supports people living in countries without a national mito organization. #Biosky mitopatients.org/members/
Zebrafish are helping scientists tackle rare #mitochondrialdiseases like MDDS
In 2018/19, Lily funded research using zebrafish to test treatments
Find out what happened in our latest Research Zone post with Research Manager Maria and Dr Ben Munro
www.thelilyfoundation.org.uk/affected-by-...
Elamipretide would be the first ever approved treatment for people with Barth Syndrome and with similar #mitochondrialdiseases like Hope. It has been life-giving and life-changing for those who have taken the drug. The @fda.gov needs to reconsider its decision. Lives are on the line. #raredisease
#DidYouKnow: Cognitive health is under-researched in primary #MitochondrialDiseases (PMD). By sponsoring the #mitoARCH study at #MitoMed 2025, we hope to break new ground in understanding the impact of PMD on cognition. Learn more: umdfconference.org/clinical-res...
Join a free, virtual, public workshop on Thurs, hosted by Reagan-Udall Foundation for FDA & focused on #ClinicalDevelopment in primary #MitochondrialDiseases. Starting ~1:30pm, Tisento’s Chad Glasser will present learnings from our MELAS development program. Register: reaganudall.org/news-and-eve...
We’re proud to advance patient-focused therapeutic development for #MitochondrialDiseases at two important events. #ReaganUdallFoundationForFDA #MitoAction #ClinicalDevelopment #MELAS www.tisentotx.com/news/tisento...
#rarediseases #MHRA #UK #PIMdesignation #UCB #DoxTM #TK2d #ThymidineKinase2Deficiency #TK2Deficiency #patientaccess #TK2geneticmutation #mitochondrialDNAdepletion #EarlyAccesstoMedicines #EAMS #MitochondrialMedicine #Mitochondrialdiseases
pharmatimes.com/news/mhra-gr...
Scientists just discovered a single molecule that may treat rare, devastating mitochondrial diseases #Science #HealthandMedicine #Genetics #MitochondrialDiseases #GeneticResearch #HealthInnovation
Fu et al, Engineering mtDNA deletions by reconstituting end joining in human mitochondria https://www.cell.com/cell/abstract/S0092-8674(25)00194-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425001941%3Fshowall%3Dtrue
A new collection of papers on #mitochondrialdiseases is ready: biomed.news/bims-mitdis/...
Congratulations to all authors!
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria
READ THIS ARTICLE IN FULL ON BRAIN HEALTH ON-LINE: #HighAltitudeLiving #MitochondrialDiseases #LeighSyndrome #HypoxyStat #BiomedicalResearch #Longevity #HealthInnovation #DrugDevelopment #GeneticConditions #ClinicalTrials #OxygenTherapy #GladstoneInstitutes #MazeTherapeutics #CellularHealth #Brain
My lab at #EmoryUniversity is seeking a #Postdoc candidate with expertise in #proteinbiochemistry to continue our exciting work on engineered protein therapies for #MitochondrialDiseases and #MetabolicDiseases. Email me to discuss this further. Please repost! #Proteinengineering #proteintherapy
