A comprehensive overview of the structure and function of #MolecularChaperones, their physiological mechanisms, and their roles in disease #pathogenesis, with insights into strategies targeting chaperone systems. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review provides a comprehensive overview of #ProteinFolding biology, detailing the roles of key #MolecularChaperones, the multifactorial causes of #ProteinMisfolding, and emerging therapeutic innovations targeting #Proteostasis.

#OpenAccess: doi.org/10.1038/s413...

Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

This review provides a comprehensive analysis of #ProteinFolding biology, highlighting #MolecularChaperones, causes of #misfolding, disease links, and therapeutic strategies targeting #proteostasis to restore protein homeostasis. #medsky

#OpenAccess #STTT: doi.org/10.1038/s413...

Advances in the structures, mechanisms and targeting of molecular chaperones - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Advances in the structures, mechanisms and targeting of molecular chaperones

Summarizing the structure, functions and regulatory mechanisms of different #HeatShockProteins, their role in the #pathogenesis of various diseases, with insights into therapeutic approaches that target these #MolecularChaperones.

#STTT #OpenAccess:

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

Featured today by @MSKLibrary: Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation

dx.doi.org/10.1038/s414...

#EpichaperomeResearch #CancerBiology #CellSignaling #Phosphorylation #MolecularChaperones #CellularAdaptability #BiomedicalResearch

Hello! As a new user, I thought I would introduce myself. I am a postdoc in the lab of @kulathu.bsky.social at MRC-PPU, Dundee, UK. Fascinated by #molecularchaperones and #proteinqualitycontrol. Find me on pubmed pubmed.ncbi.nlm.nih.gov?term=Logesva... or here scholar.google.com/citations?us...