#LipidNanoParticle functionalized with Myomerger extracellular domain for #SkeletalMuscle targeting (+ liver detargeting by 85% at 24 h i.m 😎) delivery of nucleic acids

⏬ innate immune response in lymph node & muscle by 24 h i.m.

#MyoSky

#MolTherapy 2026
www.cell.com/molecular-th...

Vascular Rarefaction precedes #Cachexia Cancer-induced #SkeletalMuscle Wasting

A remote Tumor (⏫Activin A)-Muscle (⏬#EndothelialCell PGC1α) crosstalk

Lenti-Cdh5-PGC1α intramuscular⏬Cachexia

tumor⏫ SkM EC #EndMT OXPHOS ROS

#Myosky
@jalees.bsky.social #NatCancer 2025
www.nature.com/articles/s43...

#FibroAdipogenicProgenitor #FAP

Pdgfra+ FAP IGF-1 KO🐭
👉No baseline #SkeletalMuscle anomalies in 1 mo
👉⏬FAP proliferation ⏫FAP #Senescence⏬Pax7+ MuSc⏬Myofiber size in BaCl2 SkM injury
👉Impaired fibrotic AND adipogenic capacities of FAP in vivo

#MyoSky
bioRxiv 2025
www.biorxiv.org/content/10.1...

MuscleJ2

ImageJ/Fiji plugin for #SkeletalMuscle (immunofluorescence, transverse section) Composition/Cartography😎

Myofibre (size shape metabolic types)
Microvessel
Myonuclei
Satellite cell
Immune cells

#MyoSky
#SkeletalMuscle 2023
skeletalmusclejournal.biomedcentral.com/articles/10....

A mouse heart ventricle photographed using differential interference contrast (DIC) microscopy. This thin section shows the heart's outer surface at the top, with cardiac muscle (including trabeculae) and blood cells visible throughout. #CellBiology #CardioSky #MyoSky

Sarcomeres and mitochondria in a cardiac myocyte (heart muscle cell) in the ventricle of a mouse heart photographed through an electron microscope. #Science #Biology #CellBiology #microscopy #myosky #cardiosky

Second co-corrisponding preprint is out! In collaboration with Alessandra Sacco group, we manage to double the yield of PAX7+ SMPCs generated in vitro and to mature them to a postnatal stage by modulation JAK2/STAT3 signaling.
Thanks to CIRM and MDA for their support

#myosky #myogenesis #DMD

24 hours a day for 3 days is a big effort. Need a big team with diverse skillsets working at least 16-hour shifts (often 20+) to make it all work. Great to have some of the world's top experimentalists here. #MyoSky #MyoBlue 🧪🔬🙏🔬♥️👨‍🔬👩‍🔬🫡

Definitely liking it here. Are we going for #myoblue or #myosky?

Let’s try out this new platform by sharing our recent paper on the transcriptional signatures of individual muscle fibers following high-intensity exercise
#myoblue #myosky

journals.physiology.org/doi/abs/10.1...

Titin has been studied for 40 years and yet titins function in active force manipulation is still unresolved. This goes double for how it impacts force profiles during muscle length change of *any* typical animal movement. This focused area in muscle science is what I try to uncover. /end #MyoSky

I’ve also being using #MyoSky due to seeing other sci comm posts using the Sky part of the platform in hashtags. I still like MyoBlue though 😂

Myonuclei are lost with #Ageing & Atrophy #SkeletalMuscle
#MyoSky

Satellite cells contribute to uninjured myofibers in adult 🐭

4% myonuclei turnover per 8 wk

How "old" myonuclei are removed from a multinucleate syncytium?

#JPhysiol 2022
physoc.onlinelibrary.wiley.com/doi/10.1113/...

The immune landscape of murine skeletal muscle regeneration and aging

pubmed.ncbi.nlm.nih.gov/39541212/ | #MyoSky

Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage

pubmed.ncbi.nlm.nih.gov/39543356/ | #MyoSky

Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting - PubMed Cancer cachexia affects up to 80% of cancer patients and results in reduced quality of life and survival. We previously demonstrated that the transcriptional repressor Forkhead box P1 (FoxP1) is upreg...

Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting

pubmed.ncbi.nlm.nih.gov/39545377/ | #MyoSky

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms | #MyoSky

pubmed.ncbi.nlm.nih.gov/39537626/

Cover of Nature Cardiovascular Research, with cover art from Loescher, Hessel, Linke et al. The sources of myocardial passive stiffness.

New paper! Understanding titin's contribution to myocaridal stiffness! Excited that we got the cover for our work (Andreas Unger's skills on display)! Great work by the fabulous Christine Loescher and everyone on this paper! #MyoSky #Heart #Cardiophysiology
Read it here: nature.com/articles/s4416…

Remodelling of Skeletal Muscle Myosin Metabolic States in Hibernating Mammals bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Preprint alert! Huge effort led by Chris Lewis (Uni Copenhagen) on the muscle physiology of hibernating animals. Happy that I could play a small roll in this massive project. #MyoSky #Muscle #Physiology
www.biorxiv.org/content/10.1...