Was machen wir eigentlich bei nanodiag BW?

Kurz gesagt: Wir wollen Krankheiten früher erkennen – mit Nanoporen-Technologie.

Wie das funktioniert, erklärt unsere Clustermanagerin Hannah Asselblatt in unserem neuen Video.

#nanodiagBW #Nanopores #Epigenetics #ScienceCommunication

...people hugely differing in age, backgrounds, education... A real challenge for me, but how eager they were to learn & how #grateful! Heartwarming to hear the metaphors (🍝,🍯,🐎,📻 for #FRET, 🐘&🐜 for #nanopores,...) helped them to understand, and even inspired them to think further.

We discussed...

Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNAArg Abstract. We demonstrate that solid-state nanopore sensing is a powerful single-molecule method for analyzing RNA conformational ensembles. As a model, we

(1/2) Just published in @narjournal.bsky.social !

One nucleotide. One mutation. Neurodegeneration.

We employed nanoscale sensors to watch RNA fold in real-time — molecule by molecule.
📖 academic.oup.com/nar/article/54/2/gkaf1411/8431130

#Nanopores #RNA #Biosensing #CryoEM #SAXS

Multifractal analysis reveals how nanopore complexity controls gas occurrence in Zhaotong area. Mesopores and lithofacies type dominate reservoir quality in tectonically complex areas. #Openaccess at h7.cl/1hI8Y
#naturalgas #ShaleGas #Nanopores #EnergyGeology

Imec Achieves Breakthrough in Wafer-Scale Solid-State Nanopore Manufacturing with EUV Lithography Imec has successfully developed solid-state nanopores on a wafer scale using EUV lithography, revolutionizing biosensor applications in healthcare.

Imec Achieves Breakthrough in Wafer-Scale Solid-State Nanopore Manufacturing with EUV Lithography #Belgium #Leuven #EUV_Lithography #Imec #Nanopores

Imec Achieves First Successful Production of Solid-State Nanopores Using EUV Lithography Imec has successfully demonstrated the first large-scale fabrication of solid-state nanopores using EUV lithography, advancing applications in biosensors and genomics.

Imec Achieves First Successful Production of Solid-State Nanopores Using EUV Lithography #Belgium #Leuven #Lithography #Imec #Nanopores

Imec Achieves First Large-Scale Solid-State Nanopore Wafer Production Using EUV Lithography Imec has made a groundbreaking achievement by successfully fabricating solid-state nanopore wafers at scale, paving the way for advanced biosensing applications in genomic and proteomic research.

Imec Achieves First Large-Scale Solid-State Nanopore Wafer Production Using EUV Lithography #Belgium #Leuven #EUV_Lithography #Imec #Nanopores

Breakthrough in Solid-State Nanopores: Imec Achieves Wafer Scale Production Using EUV Lithography Imec has successfully fabricated solid-state nanopores at wafer scale with EUV lithography, paving the way for advanced biosensor applications in health and life sciences.

Breakthrough in Solid-State Nanopores: Imec Achieves Wafer Scale Production Using EUV Lithography #EUV_Lithography #Imec #Nanopores

Imec's Breakthrough in Wafer-Scale Fabrication of Solid-State Nanopores Using EUV Lithography Imec recently achieved a pioneering feat in semiconductor technology by fabricating solid-state nanopores at a wafer scale using EUV lithography, paving the way for advanced biosensing applications.

Imec's Breakthrough in Wafer-Scale Fabrication of Solid-State Nanopores Using EUV Lithography #Belgium #Leuven #EUV_Lithography #Imec #Nanopores

Imec Achieves Milestone in Nanotechnology with EUV Lithography Breakthrough Imec has successfully developed a wafer-scale method for fabricating solid-state nanopores using EUV lithography, advancing biosensing technology for healthcare applications.

Imec Achieves Milestone in Nanotechnology with EUV Lithography Breakthrough #Belgium #Leuven #EUV_Lithography #Imec #Nanopores

Imec Achieves Breakthrough in Wafer-Scale Solid-State Nanopore Fabrication Using EUV Lithography Imec introduces a pioneering method for the mass production of solid-state nanopores utilizing EUV lithography, enhancing biodetection capabilities.

Imec Achieves Breakthrough in Wafer-Scale Solid-State Nanopore Fabrication Using EUV Lithography #Belgium #Leuven #EUV_Lithography #Imec #Nanopores

Lumen charge governs gated ion transport in β-barrel nanopores - Nature Nanotechnology By unifying data from engineered β-barrel nanopores and supported by modelling, it is demonstrated that the lumen charge in a β-barrel nanopore governs rectification and voltage-driven gating, with ap...

New paper: Lumen charge governs gated ion transport in β-barrel nanopores.

Data from engineered #nanopores, supported by modeling, show lumen charge governs rectification & voltage-driven gating, with potential applications in #computing using #nanofluidic synapses.

www.nature.com/articles/s41...

Pores so TINY, yet so HUGE? 🤔

Learn about the science behind this year’s @nobelprize.bsky.social in Chemistry!

Follow @chemistryunwrapped.bsky.social for more content

@chem.uzh.ch @chemsky.bsky.social #chemsky #MOF #nanopores

The image on the cover shows two sugars from the same cell-surface glycan separated by 9 Å, visualized with RESI (resolution enhancement by sequential imaging) enabled by metabolic labelling with DNA barcodes. IMAGE: Luciano A. Masullo, Max Planck Institute of Biochemistry, Germany. COVER DESIGN: Vanitha Selvarajan Original paper: Masullo, L.A., et al. Ångström-resolution imaging of cell-surface glycans. Nat. Nanotechnol. 20, 1457–1463 (2025). https://doi.org/10.1038/s41565-025-01966-5 Abstract: Glycobiology is rooted in the study of monosaccharides, ångström-sized molecules that are the building blocks of glycosylation. Glycosylated biomolecules form the glycocalyx, a dense coat encasing every human cell with central relevance—among others—in immunology, oncology and virology. To understand glycosylation function, visualizing its molecular structure is fundamental. However, the ability to visualize the molecular architecture of the glycocalyx has remained challenging. Techniques such as mass spectrometry, electron microscopy and fluorescence microscopy lack the necessary cellular context, specificity and resolution. Here we combine resolution enhancement by sequential imaging with metabolic labelling, enabling the visualization of individual sugars within glycans on the cell surface, thus obtaining images of the glycocalyx with a spatial resolution down to 9 Å in an optical microscope.

Now online: October 2025 Issue.

- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...

www.nature.com/nnano/volume...

Nanopore Sensor Platform Uses Speed Cameras to Identify Gases

KU Leuven unveiled a modular sensor using a metal‑organic framework that records molecular speed, providing kinetic selectivity even in humid air. Read more: getnews.me/nanopore-sensor-platform... #nanopores #gasdetection

#1: #PhD Position in Single-Molecule Biophysics using Nanopore Trapping:

➤ solid-state and biological #nanopores
➤ label-free protein fingerprinting, enzyme catalysis & more
⏰: submit by Sept. 20, 2025.

More info & online application system: jobs.unibas.ch/offene-stell...

Home | Research Group Schmid | University of Basel

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules

We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.

Please share broadly, thank you!🤝

schmid.chemie.unibas.ch

Size and Chemical Environment Control Nanopore Geometry in 2D MoS2: From Irregular to Triangular Defects This work addresses a longstanding challenge of developing a predictive framework for defect topologies in 2D MoS2. By combining density functional theory calculations, kinetic Monte Carlo simulation...

Our work on modeling extended defects in MoS2 is now out in Small!

onlinelibrary.wiley.com/doi/10.1002/...

We show how size and chemical environment affect nanopore geometry in MoS2, changing pore shapes from irregular to triangular.

#2Dmaterials #Nanopores #MaterialsModeling #DefectEngineering

Today at #PLASMONICA2025 we witnessed the dawn of "nanoporonics"! Denis Garoli from #UniMoRe abd #IIT Genova showed us (logic) gates realized with #plasmonic #nanopores 🕳️

Nanopores are tiny holes which have a range of applications that are benefiting society. At the University of Illinois, Prof Jean-Pierre Leburton is investigating how #nanopores can detect DNA and generate electricity.
futurumcareers.com/how-can-tiny...
#scicomm

In our latest collection of free #education resources we explore #nanotechnology with Prof Jean-Pierre Leburton at the University of Illinois. He is investigating how #nanopores can detect #DNA and generate #electricity.
futurumcareers.com/how-can-tiny...
#scicomm #edusky

nanodiag BW beim CECAM Flagship Workshop on nanopores in Cagliari 🇮🇹 Theorie & Experiment im spannenden Austausch – großartig organisiert, mit u.a. Jan C. Behrends, Christian Holm & Co. #nanopores #CECAM #forschung #nanodiagBW

Biochemical Society announces 2026 award recipients Following another record year of nominations, the work and contribution of seventeen eminent bioscientists, outstanding educators and exceptional early career researchers has been acknowledged in the ...

Congratulations to @ceesdekker.bsky.social #TUDelft, winner of the 2026 Biochemical Society Award for a Significant Breakthrough or Achievement! www.biochemistry.org/about-us/new...
#nanopores for #proteinsequencing; #chromosome structure; #building living #syntheticcell from lifeless #molecules.

In der neuen Cluster Story erklärt Tobias Groß, wie die PICO-Technologie Proteine digital messbar macht – präzise, referenzfrei und mit großem Potenzial für Medizin & Forschung. Jetzt Video ansehen: youtu.be/37pHwfrQu6s #nanopores #actome #picotechnology

Impact of Translocation Dynamics and Bandwidth on the Readout of DNA Structural Barcodes with Membrane-Based Solid-State Nanopores Recent advances in nanopore technology have promoted significant progress in single-molecule detection and analysis. In particular, membrane-based solid-state nanopores show promise as highly scalable readout platforms. This study explores the detection performance of this class of nanopores, with a focus on their application in molecular sensing schemes using DNA structural barcodes. The barcode structures, here specifically a series of dumbbell-shaped hairpins, encode information in a dumbbell-bit, which modulates the nanopore ionic current during translocation for readout. Our experiments evaluate the detection capabilities of membrane-based solid-state nanopores with a diameter of ∼15 nm. We investigate the detection success rates of individual dumbbell-bits with lengths ranging from 5 dumbbells (∼35 nm) to 29 dumbbells (∼195 nm) and with varying transmembrane potential. Longer dumbbell-bits exhibit a quasi-constant detection rate, whereas shorter bits show a significant decrease in the detection rate with increasing voltage. The observed dependencies are shown to be due to the increasing translocation velocity with voltage, in combination with the temporal resolution limit of the measurement system. Moreover, we show that a local increase of the effective charge at the dumbbell-bits leads to a proportionally increased local translocation velocity. This local velocity increase further degrades the detection success rate for dumbbell-bits. The findings in this study enhance our understanding of the fundamental limitations and capabilities of nanopore technology in high-throughput biosensing applications and have important implications for the design and optimization of future molecular assays and solid-state nanopore readout platforms.

Juliette Gevers' work on the exploration of the single-molecule detection capabilities of DNA membrane-based solid-state nanopores has been published in ACS Nano. Her work focuses on molecular sensing schemes using DNA structural barcodes.
#nanopores
pubs.acs.org/doi/abs/10.1...

Sequencing by expansion (SBX) https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1.full.pdf

Sequencing by Expansion (SBX) — a novel, high-throughput single-molecule sequencing technology. #SBX #SequencingByExpansion #Nanopores #Sequencing #Genomics #Roche 🧬 🖥️
www.biorxiv.org/content/10.1...

A new study introduces poly(C9) #nanopores, self-assembled from complement component 9, for precise single-protein analysis. poly(C9) nanopores enable highly sensitive and accurate characterization of a wide range
of natively folded proteins on a single molecule level.
www.nanion.de/news/self-as...

Nice to also hear about #nanopores in 2D materials in the last talk for today by Wei-Lun Hsu here at #SMPS4

Inspiring talk by Amit Meller here at #SMPS4 in which he also extolled the virtues of solid-state #nanopores (such as higher capture rates). :-)

@ceesdekker.bsky.social presenting a flurry of results here at #SMPS4. Amazing how many cutting edge projects are conducted in his lab! Take-away: #nanopores are super sensitive sensors, but sometimes you need a helping hand from modelling and simulations. :-)