Hiro Furukawa @lab-furukawa.bsky.social @cshlnews.bsky.social provides commentary on new work by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.
Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf
Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.
Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.
Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf
Excited to share that our newest paper has been accepted. We investigated how glycine modulates dendritic integration and which role GlyTs and GlyRs play in this.
www.sciencedirect.com/science/arti...
Congratulations also to Vincent and @chenneberger.bsky.social
#glycine #NMDAR #dendrite
Screenshot of the title page of the paper including the abstract and some introduction
Have YOU ever wanted to assess NMDAR-dependent excitotoxicity ex vivo? Perhaps you have a disease model and you want to know if excitotoxic cell death is a key player. Well, check out our new methods paper to learn how! 💫
www.sciencedirect.com/science/arti...
#neuroscience #excitotoxicity #NMDAR
Photo of a water bottle with the ExTINGUISH Trial for NMDAR Encephalitis at the top of a mountain peak in Banff in the background.
Still climbing. ⛰️
Still raising awareness. 🧠
Still enrolling in this critical clinical trial to bring patients with #NMDAR Encephalitis the evidence they so desperately need and deserve. 🤝
youtu.be/dIhD8y-hyPM?si…
Differences in sex and genetic status affect the disruption of NMDAR-related amino acid homeostasis in Parkinson's disease
Carrillo, F., Di Maio, A. et al.
Paper
Details
#ParkinsonsDisease #NMDAR #AminoAcidHomeostasis
Are you a Brains & Behavior Fellow defending your dissertation soon? Send us a DM or contact us via email with your dissertation flier to advertise your accomplishments here!
#dissertationdefense #brainsandbehavior #bnb #gsu #neuroscienceresearch #NMDAR #neuralmechanisms #academicmilestone
This is a low expressing yet pharmacologically relevant receptor subtype targeted by the antidepressant ketamine. We analyzed its channel blocking function by #cryo-EM #MD-sim #nmdar by our amazing #Hyunook-Kang #Max-Epstein
Many thanks to @Fanis Missirlis and @Liliana Quintanar for organizing an exciting #ISZB-2024 meeting and for the opportunity to share and receive feedback on some of our unpublished data.
#science #zinc #biophysics #ionchannels #NMDAR #iGluR
We just published the interesting story of the making of an #NMDAR targeting compound that showed promising effects in preclinical models predicting anti-depressant effects. To get the compound into the brain we used a prodrug strategy.
1/ Excited to share our latest research on Chimeric Autoantibody Receptor (CAAR) T cells targeting NMDA receptor-specific B cells! This could be a game-changer for treating #NMDAR #encephalitis.
www.sciencedirect.com/science/arti... #CAART #neuroscience #immunotherapy
