Frontiers | Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics Development of oral, broad-spectrum therapeutics targeting SARS-CoV-2, its variants, and related coronaviruses could curb the spread of COVID-19 and avert fu...

New study uses computational modelling + pseudotyped virus assays to identify broad-spectrum antivirals that block coronavirus cell entry. A step forward in rapid antiviral development.
www.frontiersin.org/journals/mol...
#Virology #PseudotypedVirus #DrugDiscovery #COVID19 #Pseudotyping

🧬This study used a luciferase-expressing influenza virus pseudotype to track infection in mice via bioluminescent imaging, following immunisation with a quadrivalent influenza vaccine.
www.mdpi.com/1999-4915/17...
#Influenza #PseudotypedVirus #VaccineResearch #Virology #Pseudotyping

Distinct region-specific neutralization profiles of contemporary HIV-1 clade C against best-in-class broadly neutralizing antibodies | Journal of Virology While the development of vaccines to prevent HIV infection remains a global priority, their potential effectiveness is limited by the extraordinarily diversified circulating forms of HIV-1. The prospect of best-in-class broadly neutralizing antibodies (...

This recent study highlights how contemporary HIV-1 clade C viruses circulating in India are evolving in ways that significantly affect the effectiveness of broadly neutralising antibodies.
journals.asm.org/doi/10.1128/... #Virology #HIV #AntiViral #Virology #PseudotypedVirus

Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities - Scientific Reports Scientific Reports - Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities

🧬 New BASV Vaccine Study 🧪
Researchers immunised rabbits with four vaccine types targeting BASV glycoprotein and assessed neutralising antibodies using a pseudotyped virus microneutralisation assay.
www.nature.com/articles/s41...
#Vaccines #BASV #VaccineDevelopment #PseudotypedVirus

5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells Baicalin, a bioactive flavone found in Scutellaria baicalensis Georgi has anti-SARS-CoV-2 infection by targeting viral 3C-like protease (3CLpro). Howe…

🧬This study investigates the antiviral potential of 5,6-dihydroxyflavone (5,6-DHF), a naturally occurring flavonoid, against betacoronaviruses including SARS-CoV-2 Omicron EG.5.1.1 and HCoV-OC43. www.sciencedirect.com/science/arti...
#Virology #PseudotypedVirus #Antivirals #SARSCoV2

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses Multispecific antibodies harness the advantages of two or more mAbs. In this study, we designed novel trispecific antibodies, Tri-1 and Tri-2, derived from our previously identified mAbs, PW5-5, PW5-...

🔬Novel tri-specific antibodies demonstrate potent neutralisation of SARS-CoV-2 variants and related sarbecovirus pseudotyped viruses.🧬

onlinelibrary.wiley.com/doi/10.1002/...
#Virology #Pseudotyping #PseudotypedVirus #Abs #Antivirals #COVID19 #SARSCoV2 #VirusNeutralisation

HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes Antibodies to human papillomavirus (HPV) primarily recognize surface exposed residues on five loops of the major capsid protein (L1) that vary significantly among HPV types. We determined which loops ...

This recent preprint used HPV16 viral pseudotypes to explore the diversity and molecular characteristics of human monoclonal antibodies (mAbs) generated following HPV vaccination.
#Virology #Pseudotyping #PseudotypedVirus #HPV #mAbs #Vaccination
www.biorxiv.org/content/10.1...

Assessing anti-rabies vaccine response in humans: A rapid and high-throughput adaptable, pseudovirus-based neutralization assay as an alternative to rapid fluorescence focus inhibition test (RFFIT) Author summary Rabies causes approximately 59000 deaths every year world-wide. It is also among one of the neglected tropical diseases aimed to achieve ‘Zero by 30’ as per the UN Sustainable Developme...

🧬Rabies Pseudotype Neutralisation Assay: A Safer, Faster Way to Monitor Vaccine Responses

journals.plos.org/plosntds/art...
#RABV #Rabies #Pseudotyping #PseudotypedVirus #Virology #HighThroughPut #NeutralisationAssay #PublicHealth #VaccineResearch

Frontiers | FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry

🧪 Drug repurposing using pseudotyped virus
A recent study used a SARS-CoV-2 pseudotyped virus system to screen drugs for potential inhibitors of viral entry. frontiersin.org/journals/pha...
#PseudotypedVirus #SARSCoV2 #Virology #AntiviralResearch #COVID19 #VirusEntry #Pseudotyping

Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants | mBio The emergence of novel severe acute respiratory syndrome coronavirus 2 variants continues to pose challenges for global public health, particularly in the context of immune evasion and viral stability...

🧬 DelS31 Mutation: A Key Player in COVID-19 Evolution 🧬
This study investigates the impact of the DelS31 mutation in JN.1-derived COVID-19 variants.
journals.asm.org/doi/10.1128/...
#COVID19 #SARSCoV2 #Pseudotyping #PseudotypedVirus #Vaccine

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#Virology #Research #VirionX #PseudotypedVirus #Pseudotyping #biotech

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This study explored Exifone, a clinical polyphenolic compound, as a potential treatment for COVID-19. It binds to the SARS-CoV-2 3CL protease and disrupts ACE2/S-RBD interaction. lnkd.in/e7sMyMcB
#Pseudotyping #Antiviral #COVID19 #Virology #SARSCoV2 #PseudotypedVirus

🚀 Exciting news! We’re launching Virion X, a biotech dedicated to making critical virology research more accessible. We’re building a waitlist so you’ll be the first to know when we go live. lnkd.in/emSCjXcY
#VirionX #Virology #Pseudotyping #Biotech #startup #pseudotypedvirus

This preprint uses pseudotyped virus deep mutational scanning to map HIV escape mutations against two broadly neutralising antibodies, 10-1074 & 3BNC117, revealing strain-dependent differences.
#HIV #virology #antibodies #pseudotyping #pseudotypedvirus
www.biorxiv.org/content/10.1...

Bridge protein-mediated viral targeting of cells expressing endogenous μ-opioid G protein-coupled receptors in the mouse and monkey brain Targeting specific cell types is essential for understanding their functional roles in the brain. Although genetic approaches enable cell-type-specifi…

Novel Bridge Protein Strategy for Cell-Specific Delivery of Pseudotyped Viruses.
#virology #pseudotyping #pseudotypedvirus #tropsim #proteinengineering
www.sciencedirect.com/science/arti...